2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
1Brigham and Women's Hospital, Boston, MA, 2Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…2022 American Transplant Congress
Temporal Trends in Utilization, Discard, and Outcomes for Extended Criteria Donor Lungs
1Johns Hopkins, Baltimore, MD, 2Baylor, Houston, TX
*Purpose: Extended criteria donor lungs (ECDL) are defined as those failing to meet ≥1 standard donor criteria (P/F > 300, age < 55, smoking <…2022 American Transplant Congress
Predicting Long Term Kidney-Allograft Failure: Machine Learning vs Traditional Statistical Models
1Paris Transplant Group, Paris, France, 2Hôpital Saint-Louis, Paris, France
*Purpose: Prognostic models have been developed in organ transplant over the past years using traditional statistical models. However, whether these are outperformed by machine learning…2022 American Transplant Congress
No Difference in Graft Survival Among Low Socioeconomic Kidney Allograft Recipients
*Purpose: Low socioeconomic status remains a barrier in access and equity in kidney transplantation with limited data assessing post-transplant outcomes. Alternative options to transplantation include…2022 American Transplant Congress
Coordinated, Multimodal Care After Kidney Transplantation Improves Graft Survival and Cardiovascular Risks – Results of the Kidney Transplantation 360°- Study (ktx360°)
*Purpose: Cardiovascular events and reduced graft survival due to non-adherence are the most important reasons for morbidity and mortality after KTx. Outpatient care in Germany…2022 American Transplant Congress
Safety and Efficacy of a Probiotic Protocol to Reduce Perioperative Infection After Liver Transplantation
University of Wisconsin Health, Madison, WI
*Purpose: Evaluate efficacy and safety of a probiotic preparation to reduce perioperative infection in patients undergoing liver transplant surgery*Methods: Adult patients receiving liver transplantation from…2022 American Transplant Congress
Long-Term Rejection Free Renal Allograft Survival with Fc-Modified Anti-cd154 Antibody Monotherapy in Nonhuman Primates
MGH Center for Transplantation Sciences, Boston, MA
*Purpose: Belatacept is currently the only FDA approved costimulatory blockade (CB) used as an alternative to calcineurin inhibitors in kidney transplantation. However, it has been…2022 American Transplant Congress
Utilisation and Clinical Outcomes of Kidney Transplants from Deceased Donors with Albuminuria in the UK: A Cohort Study
*Purpose: Urinalysis is a standard component of the assessment of potential deceased kidney donors in the UK. The value of albuminuria as a biomarker for…2022 American Transplant Congress
Treg Tissue Stability Depends on Adenosine Receptor Driven Lymphatic Endothelial Cell Responses
1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN
*Purpose: Regulatory T cell (Treg) lymphatic migration and maintenance of transcription factor Foxp3 expression are required for suppressor function and allograft protection. Migrating Tregs were…2022 American Transplant Congress
Variability In Plasma Donor-derived Cell-free DNA Levels With CLAD More Than 5-years After Lung Transplantation: Pilot Data
1Department of Medicine, University of Texas, San Antonio, San Antonio, TX, 2Natera, Inc., Ausin, TX
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been clinically validated for detection of acute rejection (AR) in lung transplant (LT) although studies have typically focused on…
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