2022 American Transplant Congress
Effector T Cells Potentiate Treg Migration to Allografts
Surgery and Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA
*Purpose: CD4+ regulatory T cells (Treg) maintain transplantation tolerance through the suppression of immunity in both secondary lymphoid organs and allografts. However, the signals promoting…2022 American Transplant Congress
Lymphotoxin Beta Receptor Classical NFkB Signaling in Lymphatic Endothelial Cells Drives Treg Tissue Stability
1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN
*Purpose: Regulatory T cell (Treg) suppressor function and allograft protection depend on maintenance of transcription factor Foxp3 expression and lymphatic migration, respectively. Treg lymphotoxin (LT)…2022 American Transplant Congress
Distinct Phenotypes of Kidney Transplant Recipients with Delayed Graft Function Identified Through Machine Learning Consensus Clustering
*Purpose: The significance of delayed graft function (DGF) and its impact on kidney transplant (KT) outcomes remains debated. We aimed to assess outcomes for KT…2022 American Transplant Congress
Chronic Ethanol Exposure Prolongs Murine Allograft Survival
Department of Surgery, Emory University, Atlanta, GA
*Purpose: Alcoholic liver disease is the leading indication for liver transplantation in the United States, and patients are increasingly transplanted without the traditional six month…2022 American Transplant Congress
Ultrasound Assessing Donor Kidney Quality in Deceased Donor Kidney Transplantation
*Purpose: We evaluated the role of functional kidney volume using donor kidney ultrasound (US) alone or in combination with other donor factors and parameters appropriate…2022 American Transplant Congress
Living Donor Kidney Transplant in Recipients with Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes
1Nephrology, University of Minnesota, Minneapolis, MN, 2MHealth, Minneapolis, MN
*Purpose: Controversies exist over the impact of donor-recipient biologic relationship on the outcomes of living donor kidney transplant in recipients with glomerulonephritis (GN). The improved…2022 American Transplant Congress
Clinical Significance of the Living Kidney Donor Profile Index in Living Kidney Donors for Predicting of Post-Transplant Outcome: Korean Organ Transplantation Registry
*Purpose: According to recent reports, a risk index for living donor kidney transplantation (LDKT) such as the Kidney donor profile index (KDPI), a non-invasive method…2022 American Transplant Congress
Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity
1Surgery, UMB, Baltimore, MD, 2Harvard University, Boston, MA
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…2022 American Transplant Congress
Depletion of Donor Macrophages Permits Post-Transplant Tolerance Induction
*Purpose: Using donor splenocytes fixed with cross-linker ethylcarbodiimide (ECDI-SPs), our lab has induced tolerance in a variety of murine and non-human primate models when one…2022 American Transplant Congress
Recurrence of Membranous Nephropathy After Kidney Transplantation – TANGO Consortium
1Harvard Medical School, Boston, MA, 2Mount Sinai, New York, NY
*Purpose: Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Several breakthroughs in recent decades, including the identification of anti-PLA2R Abs, aided…
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