Articles tagged "Graft survival"

2017 American Transplant Congress
CD4⁺/CD8⁺ T Cell Ratio as a Predictive Marker for Early Graft Failure in Pig to Non-Human Primate Islet Xenotransplantation with Immunosuppression.
S. Choi,^1,3,4 H.-J. Kim,^1,2,3,4 I.-H. Yoon,^1,2 J.-S. Kim,^1,2,6 S.-J. Kang,^1,2,3,4 H.-Y. Nam,^1,2 B.-H. Min,¹ J.-S. Shin,^1,6 J.-M. Kim,^1,6 Y.-H. Kim,^1,5 W.-W. Lee,^1,2,3,4 C.-G. Park.^1,2,3,4,6
¹Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea; ²Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea; ³Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; ⁴Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea; ⁵Department of Microbiology, Kyungpook National University School of Medicine, Daegu, Korea; ⁶Institute of Endemic Diseases, Seoul National University College of Medicine, Seoul, Korea
Background: Outstanding results from nonhuman primate study put islet xenotransplantation with immunosuppression closer to the clinical application. To establish successful immune suppressive protocols, immune monitoring…
2017 American Transplant Congress
Beta Cell-Specific Free Circulating DNA May Predict the Outcome After Clinical Islet Transplantation.
B. Gala-Lopez,¹ D. Neiman,² T. Kin,¹ D. O'Gorman,¹ A. Pepper,¹ A. Malcolm,¹ B. Glaser,³ R. Shemer,² Y. Dor,² J. Shapiro.¹
¹Department of Surgery, Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada; ²Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; ³Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Optimizing engraftment and early survival of human beta cells after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures…
2017 American Transplant Congress
Obesity Is an Important Factor in Deceased but Not Living Donor Kidney Transplants.
A. Asderakis, A. Ilham, U. Khalid, R. Chavez.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom
Introduction There is an increasing obesity among potential kidney transplant recipients. We had in the past shown that obesity did increase the wound infection rate,…
2017 American Transplant Congress
Metabolomics Study for Identification of Potential Biomarkers of Long-Term Survival in Kidney Transplantation Recipients.
C.-D. Kim, H.-Y. Jung, R.-H. Kim, S.-M. Park, J.-H. Park, K.-H. Lee, E.-S. Lee, K.-Y. Kim, J.-Y. Choi, J.-H. Cho, S.-H. Park, Y.-L. Kim.
Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
Background: The development of new strategies to improve long-term survival outcome after kidney transplantation is also becoming important. Although current diagnosis of allograft dysfunction relies…
2017 American Transplant Congress
Anti-Angiotensin Type 1 Receptor Antibodies Associate with Rejection in Simultaneous Pancreas and Kidney Transplant and Pancreas Transplant Alone Recipients.
A. Peng, D. Dafoe, J. Choi, A. Vo, X. Zhang, R. Najjar, E. Huang, S. Jordan.
Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA
Background: Anti-angiotensin type 1 receptor antibodies (AT1R Ab) have been found to have a strong association with antibody mediated rejection (Reinsmoen et al, Transpl 2010;…
2017 American Transplant Congress
Impact of Type of Recipient Diabetes on 1 and 3-Year Kidney Allograft and Patient Outcomes.
S. Kim, F. Wu, D. Cibrik, Y. Li, A. Naik.
University of Michigan, Ann Arbor
The pathophysiology of type 1 (T1DM) and type 2 (T2DM) diabetes is different and has been conjectured to impact transplantation outcomes differently over time especially…
2017 American Transplant Congress
Results of Biliary Reconstruction with PTFE Graft in Liver Transplantation.
E. Ayvazoglu Soy,¹ G. Moray,¹ A. Torgay,² H. Ozdemir,³ M. Haberal.¹
¹General Surgery and Transplantation, Baskent University, Ankara, Turkey; ²Anesthesiology, Baskent University, Ankara, Turkey; ³Pathology, Baskent University, Ankara, Turkey
Introduction: Biliary complications are often referred to as the 'Achilles heel' of liver transplantation (LT) with their high incidence rate, the need for repeated and…
2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
A. Arterbery,¹ M. Martinez,³ S. Lobritto,³ Y. Avitzur,² U. Ekong.¹
¹Ped Gastro. and Hep., Yale University, New Haven, CT; ²Gastro., Hep., and Nutr., Hospital for Sick Children, Toronto, ON, Canada; ³Ped. Gastro., Hep., and Nutr., Columbia University, New York, NY
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…
2017 American Transplant Congress
Short- and Long-Term Graft Survival After Kidney Transplantation in Western Europe.
M. Coemans,¹ G. Verbeke, D. Anglicheau, O. Bestard, M. Giral, M. Naesens.^1,2
¹Microbiology and Immunology, KU Leuven, Leuven, Belgium; ²Nephrology and Renal Transplantation, KU Leuven, Leuven, Belgium
Background: Improvement of kidney survival after transplantation has mainly been studied in the American population. There, it was found that improvement mostly occurred on the…
2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
J. Erfe,^1,2 C. Yang,¹ D. Ndishabandi,¹ I. Rosales,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Yale School of Medicine, New Haven, CT
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…