Articles tagged "Graft survival"

2017 American Transplant Congress
Outcome of Living Donor Transplantation in Pediatric Recipients Over the Last Three Decades by Era: An Analysis of UNOS Database.
V. Whittaker, M. Laftavi, Z. Acun, R. Gruessner, A. Gruessner.
Surgery, State University New York, Syracuse, NY
Background: Living donor is the potential solution to organ shortage. This retrospective analysis of UNOS database evaluates the outcome of living donor transplantation across 4…
2017 American Transplant Congress
Analysis of Outcomes in High Risk Kidney Transplants.
E. Liu, M. Aull, J. Lee, S. Kapur.
Kidney and Pancreas Transplantation, NewYork-Presbyterian Weill Cornell Medical Center, New York, NY
Background: The new kidney allocation system implemented in 12/2014 utilizes estimated post-transplant survival scores (EPTS) and kidney donor profile index (KDPI) to optimize recipient survival…
2017 American Transplant Congress
Dual Treatment of Suboptimal Doses of CsA and MSC Infusion Fully Prevents Acute Rejection in an Allogenic Model of Renal Transplantation.
L. de Ramon,¹ A. Merino,¹ E. Ripoll,¹ N. Bolaños,¹ M. Gomà,³ J. Cruzado,^1,2 J. Grinyó,^1,2 J. Torras.^1,2
¹Experimental Nephrology, IDIBELL-UB, Hospitalet Llobregat, Barcelona, Spain; ²Nephrology, Hospital Universitari de Bellvitge, Hospitalet Llobregat, Barcelona, Spain; ³Pathology, Hospital Universitari de Bellvitge, Hopitalet Llobregat, Barcelona, Spain
The immunomodulatory characteristics of mesenchymal stem cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the…
2017 American Transplant Congress
New Approach for Targeted Immunotherapy in Vascularized Composite Allotransplantation.
F. Feturi,¹ H. Wang,² Y. Brudno,² V. Erbas,³ Z. Zhang,³ H. Sahin,³ D. Mooney,² V. Gorantla,³ R. Venkataramanan.¹
¹Department of Pharmaceutical Science, University of Pittsburgh School of Pharmacy, Pittsburgh, PA; ²A Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA; ³Department of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA
Vascularized composite allotransplantation (VCA) have highly immunogenic skin component mandates high doses of systemic immunosuppressive drugs. Oral dosing leads to fluctuating, unpredictable blood levels that…
2017 American Transplant Congress
mTORC1 and 2 Regulate Dendritic Cell (DC) Metabolism and Allostimulatory Function of Donor DCs in Skin Transplantation.
A. Watson,^1,2 H. Dai,^1,3 A. Menk,^4,5 G. Delgoffe,^4,5 A. Thomson.^1,2,3
¹Starzl Transplantation Institute, Univ. of Pittsburgh, Pittsburgh; ²Pathology, Univ. of Pittsburgh, Pittsburgh; ³Surgery, Univ. of Pittsburgh, Pittsburgh; ⁴Immunology, Univ. of Pittsburgh, Pittsburgh; ⁵Cancer Institute, Univ. of Pittsburgh, Pittsburgh
Background/Hypothesis: The mechanistic target of rapamycin (mTOR) is a kinase that functions in two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play critical…
2017 American Transplant Congress
Complications Requiring Reoperation After Pediatric Liver Transplantation.
D. Yoeli, J. Moffett, K. Hosek, R. Ackah, R. Sigireddi, M. Kueht, N. Galvan, R. Cotton, A. Rana, C. O'Mahony, J. Goss.
Department of Surgery, Baylor College of Medicine, Houston, TX
Context: Reoperative complications after liver transplantation have been shown to decrease patient and graft survival in adults; this effect, however, has not been studied in…
2017 American Transplant Congress
Use of Pulsatile Perfusion Modifies the Effect of Delayed Graft Function on Graft Failure.
A. Thomas, A. Shaffer, A. Massie, D. Segev.
JHU, Baltimore
While the causal mechanisms remain elusive, delayed graft function (DGF) has been associated with graft failure in recipients of deceased-donor kidneys. Pulsatile perfusion pump use…
2017 American Transplant Congress
Blocked of Bat3 Expression Promotes Transplant Tolerance by Inducing IL-10 Expression in Dendritic Cells.
G. Gu, H. Hang, Q. Xia.
Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Objective: To explore the effect of Bat3 on DCs during transplant tolerance induction.Methods: Allogeneic heart transplants were performed between WT and Bat3flox/floxCD11c-Cre+ mice, to test…
2017 American Transplant Congress
Pediatric Recipients of Deceased Adult Donor Kidneys Have Equivalent Outcomes Compared with Pediatric Donors.
D. Mikhail,¹ H. Sharma,^3,4 J. Chen,² M. Cooper,⁴ A. Sener,^1,3 P. Luke.^1,3
¹Urology, Western University, London, ON, Canada; ²Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Multi-Organ Transplant Surgery, Western University, London, ON, Canada; ⁴Transplant Surgery, Georgetown University, Washington, DC
INTRODUCTION:Efforts are made to transplant paediatric deceased donor kidneys into pediatric recipients. To our knowledge, data does not support better graft outcomes with matched pediatric…
2017 American Transplant Congress
Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity.
R. Crepeau, D. Liu, M. Ford.
Emory Transplant Center, Emory University, Atlanta, GA
Recipient-derived, graft-specific memory T cells play a critical role in mediating allograft rejection, particularly in the setting of immunosuppression with costimulation blockade. Recently, it is…