Articles tagged "Graft survival"

2017 American Transplant Congress
Inflammasome, Unfolded Protein Response, and T Cell Immunity in DAIH.
A. Arterbery,¹ M. Martinez,³ S. Lobritto,³ Y. Avitzur,² U. Ekong.¹
¹Ped Gastro. and Hep., Yale University, New Haven, CT; ²Gastro., Hep., and Nutr., Hospital for Sick Children, Toronto, ON, Canada; ³Ped. Gastro., Hep., and Nutr., Columbia University, New York, NY
Background: Regulatory T cells (Tregs) of patients with de novo autoimmune hepatitis (DAIH) secrete IL-17A & IFN-g; display TH1 & TH17 pehnotypes & are functionally…
2017 American Transplant Congress
Short- and Long-Term Graft Survival After Kidney Transplantation in Western Europe.
M. Coemans,¹ G. Verbeke, D. Anglicheau, O. Bestard, M. Giral, M. Naesens.^1,2
¹Microbiology and Immunology, KU Leuven, Leuven, Belgium; ²Nephrology and Renal Transplantation, KU Leuven, Leuven, Belgium
Background: Improvement of kidney survival after transplantation has mainly been studied in the American population. There, it was found that improvement mostly occurred on the…
2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
J. Erfe,^1,2 C. Yang,¹ D. Ndishabandi,¹ I. Rosales,¹ R. White,¹ P. Russell,¹ R. Colvin,¹ J. Madsen,¹ A. Alessandrini.¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; ²Yale School of Medicine, New Haven, CT
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
2017 American Transplant Congress
Renal Transplant Outcomes in Primary FSGS Compared with Other Recipients: A National Review of the Irish Transplant Registry.
S. Cormican,¹ C. Kennedy,^1,2 P. O'Kelly,¹ B. Doyle,³ A. Dorman,³ P. Conlon.^1,2
¹Nephrology, Beaumont Hospital, Dublin, Ireland; ²Medicine, Royal College of Surgeons, Dublin, Ireland; ³Pathology, Beaumont Hospital, Dublin, Ireland
Primary focal segmental glomerular sclerosis (p-FSGS) raises specific peri-transplant concerns, one of which is disease recurrence (r-FSGS). We aimed to compare transplant outcomes in patients…
2017 American Transplant Congress
Correlation of Complement Activating Donor Specific Antibodies as Measured by C3d and Cross-Match Status.
A. Babu,^1,2,3 N. Krishnan,² D. Briggs,³ D. Mitchell,¹ S. Daga.^1,2,4
¹Warwick Medical School, University of Warwick, Coventry, United Kingdom; ²Nephrology and Transplantation, University Hospitals Coventrya and Warwickshire, Coventry, United Kingdom; ³Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom; ⁴Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Introduction. Complement dependent cytotoxicity, first described in 1969 is the only functional assay studying complement activation. C3d assay is developed recently to study complement activation…
2017 American Transplant Congress
Beta Cell-Specific Free Circulating DNA May Predict the Outcome After Clinical Islet Transplantation.
B. Gala-Lopez,¹ D. Neiman,² T. Kin,¹ D. O'Gorman,¹ A. Pepper,¹ A. Malcolm,¹ B. Glaser,³ R. Shemer,² Y. Dor,² J. Shapiro.¹
¹Department of Surgery, Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada; ²Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; ³Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Optimizing engraftment and early survival of human beta cells after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures…
2017 American Transplant Congress
Obesity Is an Important Factor in Deceased but Not Living Donor Kidney Transplants.
A. Asderakis, A. Ilham, U. Khalid, R. Chavez.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom
Introduction There is an increasing obesity among potential kidney transplant recipients. We had in the past shown that obesity did increase the wound infection rate,…
2017 American Transplant Congress
Metabolomics Study for Identification of Potential Biomarkers of Long-Term Survival in Kidney Transplantation Recipients.
C.-D. Kim, H.-Y. Jung, R.-H. Kim, S.-M. Park, J.-H. Park, K.-H. Lee, E.-S. Lee, K.-Y. Kim, J.-Y. Choi, J.-H. Cho, S.-H. Park, Y.-L. Kim.
Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
Background: The development of new strategies to improve long-term survival outcome after kidney transplantation is also becoming important. Although current diagnosis of allograft dysfunction relies…
2017 American Transplant Congress
The Benefits of Pancreas After Kidney (PAK) Transplantation.
M. Curry,¹ J. Odorico,² J. Fridell.³
¹Research, UNOs, Richmond, VA; ²Department of Surgery, University of Wisconsin, Madison, WI; ³Department of Surgery, Indiana University, Indianpolis, IN
Background: PAK transplantation has been perceived as inferior to Simultaneous Pancreas and Kidney (SPK) transplantation with respect to patient and pancreas (PA) allograft survival. However,…
2017 American Transplant Congress
A Multidimensional Prognostic Score and Nomogram to Predict Kidney Transplant Survival: The Integrative Box (iBox) System.
A. Loupy,¹ O. Aubert,¹ B. Orandi,² A. Jackson,² M. Naesens,³ N. Kamar,¹ O. Thaunat,¹ E. Morelon,¹ M. Delahousse,¹ D. Viglietti,¹ D. Glotz,¹ C. Legendre,¹ X. Jouven,¹ R. Montgomery,² M. Stegall,⁴ D. Segev,² C. Lefaucheur.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²Johns-Hopkins, Baltimore; ³Leuven University, Leuven, Belgium; ⁴Mayo Clinic, Rochester
The transplant field currently lacks of robust risk stratification models leading to major problems for clinical care, clinical trials, and medical progress. The goal of…