Articles tagged "Graft survival"

2017 American Transplant Congress
Recipient iNOS Deficiency Reduces Spontaneous Kidney Allograft Acceptance by Accelerating Allograft Loss.
I. Aljabban, B. Jiang, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
Nitric oxide (NO) production by inducible nitric oxide synthase (iNOS), encoded by NOS2, is a hallmark of the innate immune axis, and is typically associated…
2017 American Transplant Congress
Effect of Initial Hepatic Arterial Followed by Portal Reperfusion on Outcomes After Liver Transplantation.
R. Shahbazov,¹ F. Azari,² J. Alejo,² M. Talanian,² M. Fox,² K. Kennedy,² S. Kessel,² A. Nickkholgh,¹ D. Maluf,¹ S. Pelletier.¹
¹Department of Surgery, University of Virginia Medical Center, Charlottesville, VA; ²University of Virginia School of Medicine, Charlottesville, VA
Background: While initial portal reperfusion (PV) of a liver allograft is nearly standardized, limited data suggests initial hepatic arterial reperfusion (HA) may improve hemodynamics and…
2017 American Transplant Congress
Three Induction Therapies on Patients with Delayed Graft Function After Kidney Transplantation, a Three-Year Outcome Analysis.
A. Umber, M. Killackey, A. Paramesh, B. Alper, F. Teran, A. Baudy, Y. Liu, J. Buell, R. Zhang.
Departments of Medicine and Surgery, Tulane University School of Medicine, New Orleans, LA
We compare the 3-year outcomes of induction therapies with either methylprednisolone (group 1, n=58), basiliximab (group 2, n=56) or alemtuzumab (group 3, n=98) in primary…
2017 American Transplant Congress
A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients.
R. Danger,¹ M. Chesneau,¹ C. Paul,¹ P. Guérif,¹ M. Durand,¹ K. Newell,² S. Kanaparthi,³ L. Turka,⁴ J.-P. Soulillou,¹ R. Houlgatte,⁵ M. Giral,^1,6 G. Ramstein,⁷ S. Brouard.^1,6
¹Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; ²Department of Surgery, Emory University, Atlanta, GA; ³Immune Tolerance Network, Bethesda, MD; ⁴Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; ⁵INSERM UMR 954,CHU de Nancy, DRCI, Nancy, France; ⁶CIC Biotherapy, CHU Nantes, Nantes, France; ⁷LINA DUKe, UMR 6241, Université de Nantes, Ecole des Mines de Nantes & CNRS, Nantes, France
New challenges in renal transplantation include using biological information to devise a useful clinical test for discerning high- and low-risk patients for individual therapy and…
2017 American Transplant Congress
Donor Creatinine and Graft Outcomes in Pediatric Kidney Transplant Recipients.
N. Hayde, M. Del Rio.
Montefiore Medical Center, Bronx, NY
Background: The role of donor peak and terminal creatinine on short and long term allograft outcomes in pediatric kidney transplant recipients is unclear.Aim: To determine…
2017 American Transplant Congress
Regulation of T Cell Migration by Specifically Targeting Lymphotoxin β Receptor (LTβR)-Mediated Non-Canonical NFkB Signaling.
W. Piao, Y. Xiong, C. Brinkman, J. Bromberg.
UMB, Baltimore
Background:Selective recruitment of regulatory T cells (Treg) to draining lymph nodes is crucial for graft survival, and LTαβ-LTβR signaling is required to direct Treg into…
2017 American Transplant Congress
Outcome of Living Donor Transplantation in Pediatric Recipients Over the Last Three Decades by Era: An Analysis of UNOS Database.
V. Whittaker, M. Laftavi, Z. Acun, R. Gruessner, A. Gruessner.
Surgery, State University New York, Syracuse, NY
Background: Living donor is the potential solution to organ shortage. This retrospective analysis of UNOS database evaluates the outcome of living donor transplantation across 4…
2017 American Transplant Congress
Analysis of Outcomes in High Risk Kidney Transplants.
E. Liu, M. Aull, J. Lee, S. Kapur.
Kidney and Pancreas Transplantation, NewYork-Presbyterian Weill Cornell Medical Center, New York, NY
Background: The new kidney allocation system implemented in 12/2014 utilizes estimated post-transplant survival scores (EPTS) and kidney donor profile index (KDPI) to optimize recipient survival…
2017 American Transplant Congress
Dual Treatment of Suboptimal Doses of CsA and MSC Infusion Fully Prevents Acute Rejection in an Allogenic Model of Renal Transplantation.
L. de Ramon,¹ A. Merino,¹ E. Ripoll,¹ N. Bolaños,¹ M. Gomà,³ J. Cruzado,^1,2 J. Grinyó,^1,2 J. Torras.^1,2
¹Experimental Nephrology, IDIBELL-UB, Hospitalet Llobregat, Barcelona, Spain; ²Nephrology, Hospital Universitari de Bellvitge, Hospitalet Llobregat, Barcelona, Spain; ³Pathology, Hospital Universitari de Bellvitge, Hopitalet Llobregat, Barcelona, Spain
The immunomodulatory characteristics of mesenchymal stem cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the…
2017 American Transplant Congress
New Approach for Targeted Immunotherapy in Vascularized Composite Allotransplantation.
F. Feturi,¹ H. Wang,² Y. Brudno,² V. Erbas,³ Z. Zhang,³ H. Sahin,³ D. Mooney,² V. Gorantla,³ R. Venkataramanan.¹
¹Department of Pharmaceutical Science, University of Pittsburgh School of Pharmacy, Pittsburgh, PA; ²A Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA; ³Department of Plastic and Reconstructive Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA
Vascularized composite allotransplantation (VCA) have highly immunogenic skin component mandates high doses of systemic immunosuppressive drugs. Oral dosing leads to fluctuating, unpredictable blood levels that…