Articles tagged "Graft survival"

2018 American Transplant Congress
Ex Vivo-Expanded Human CD19⁺CD73^–CD25⁺CD71⁺TIM-1⁺ B Regulatory Cells Can Prolong Allograft Survival in a Humanized Mouse Model of Skin Transplantation and Are Dependent on TIM-1-Mediated Regulation of STAT3 Signaling
S. Shankar,¹ J. Stolp,^1,2 S. Juvet,^1,3 J. Hester,¹ K. Wood.¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ²Garvan Institute of Medical Research, Sydney, Australia; ³Toronto General Hospital Research Institute, Toronto, Canada.
The importance of B regulatory cells (Breg) in both health and disease has rapidly become evident over the last decade. Breg are able to control…
2018 American Transplant Congress
Significance of Antibody-Mediated Vascular Rejection (AMVR) on Graft Survival: Correlation with Pure Antibody-Mediated Rejection (AMR)
B. Ozdemir,¹ F. Ozdemir,² A. Terzi,² G. Ozdemir,¹ A. Ok Atilgan,¹ E. Ayvazoglu Soy,³ A. Akdur,³ G. Moray,³ M. Haberal.³
¹Pathology, Baskent University, Ankara, Turkey; ²Nephrology, Baskent University, Ankara, Turkey; ³Transplantation, Baskent University, Ankara, Turkey.
Introduction: The importance of the endarteritis on graft survival in recipients with AMR is controversial. Thus we aimed to understand the prognostic value of the…
2018 American Transplant Congress
Pancreas and Kidney Co-Transplantation in Type II Diabetes: A Single Center Experience
J. Choi, J. Jung, H. Kwon, S. Shin, Y. Kim, D. Han.
Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University Ulsan College of Medicine, Seoul, Korea.
Background: Diabetic CKD patients present increased morbidity and mortality due to cardiovascular complications. Pancreas transplantation can restore insulin independence in patients with type I diabetes…
2018 American Transplant Congress
Long-Term Social Outcome after Pediatric Kidney Transplantation
Y. Hamasaki,¹ T. Matsuda,¹ M. Kubota,¹ J. Hashimoto,¹ Y. Takahashi,¹ M. Muramatsu,² T. Kawamura,³ K. Sakai,² S. Shishido.^1,2
¹Pediatric Nephrology, Toho University Faculty of Medicine, Tokyo, Japan; ²Nephrology, Toho University Faculty of Medicine, Tokyo, Japan; ³Nephrology, Sakura Medical Center, Toho University, Sakura, Japan.
BackgroundPatients' and graft survival rates after pediatric kidney transplantation (KTx) were recently improved because of progress in immunosuppressants, perioperative care, and operative procedures. Therefore the…
2018 American Transplant Congress
Time-Effect of Donor and Recipient Characteristics on Graft Survival after Kidney Transplantation
E. Molmenti,¹ J. Yang,³ C. Molmenti,² E. Grodstein,¹ H. Rilo,¹ L. Teperman.¹
¹Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY; ²Feinstein Institute, Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY; ³Epidemiology, Mailman Schoool of Public Health, Columbia University, New York, NY.
BackgroundThe current kidney allocation system (KAS) is based on the Kidney Donor Profile Index (KDPI) and the Estimated Post-Transplant Survival (EPTS), quality-based “longevity matching” strategies…
2018 American Transplant Congress
Lymph Node Stromal Laminins Modulate the Dynamic Balance of the Treg/Th17 Axis
L. Li, T. Simon, W. Piao, Y. Xiong, V. Saxena, T. Zhang, C. Wagner, J. Bromberg.
University of Maryland, Baltimore, MD.
Background: Tolerance and immunity are associated with differential expression of lymph node (LN) stromal laminins α4β1γ1 (411) and α5β1γ1 (511), respectively, which determine how alloreactive…
2018 American Transplant Congress
The Combination of Area under Curve of Estimated Glomerular Filtration Rate for 2 Years and Annual Rate Change of Estimated Glomerular Filtration Rate Predicts Long-Term Graft Survival in Kidney Transplants
E. Lee,¹ J. Jeon,¹ S. Kim,¹ M. Kim,¹ K. Lee,¹ H. Jang,¹ J. Lee,¹ J. Hwang,² D. Kim,¹ Y-.G. Kim,¹ H. Oh,¹ W. Huh,¹ J. Kim.³
¹Department of Medicine, Samsung Medical Center, Seoul, Republic of Korea; ²Department of Anesthesiology and Pain Medicine, Seoul National University BunDang Hospital, Sungnam, Republic of Korea; ³Department of Surgery, Samsung Medical Center, Seoul, Republic of Korea.
Improvement of short-term outcomes in kidney transplant (KT) has required clinical trials to evaluate long-term hard outcomes for validation of new therapies. However, because of…
2018 American Transplant Congress
ACEI/ARB Use within One Year of Kidney Transplant is Associated with Less AKI and Graft Loss in Older Recipients
M. Posadas Salas, R. Rodriguez, P. Amaechi, V. Rao, D. Taber.
Medical University of South Carolina, Charleston, SC.
As short-term outcomes have improved, optimizing long-term graft survival remains a major focus of transplant programs. Older kidney transplant recipients are particularly vulnerable to acute…
2018 American Transplant Congress
Kidney Allograft Vascular Disease Post-Transplant (KTX): Risk Factors and Implications
M. El Ters,¹ L. Cornell,² J. Grande,² F. Cosio.¹
¹Medicine, Mayo Clinic, Rochester, MN; ²Pathology, Mayo Clinic, Rochester, MN.
Background: Over time grafts develop arteriosclerosis (ART)and arteriolar hyalinosis (AH). Previous studies associated AH with calcineurin inhibitors (CNI), diabetes (DM), kidney age and hypertension. Other…
2018 American Transplant Congress
Alloreactive B Cells Acquire Cell-Intrinsic Hyporesponsiveness in Tolerant Recipients
S. Khiew,¹ D. Jain,¹ J. Young,¹ J. Chen,¹ J. Yang,¹ Q. Wang,¹ D. Yin,¹ R. Sciammas,² A. Chong.¹
¹Department of Surgery, The University of Chicago, Chicago, IL; ²Comparative Medicine, University of California, Davis, CA.
Donor-specific transplantation tolerance has long been an aspiration of clinical transplantation. Recently, we have reported that multiple mechanisms are required to reinforce profound hyporesponsiveness of…