Articles tagged "Graft survival"

2018 American Transplant Congress
Sirolimus-Based, Prednisone-Free Regimen in Kidney Transplantation: Long Term Results of an Open-Label, Randomized Controlled Trial
A. Shetty,¹ B. Ho,¹ V. Mas,² Y. Kassis,¹ S. Park,¹ J. Leventhal,¹ D. Chhabra,³ L. Gallon.¹
¹Northwestern University, Chicago; ²University of Virginia, Charlottesville; ³Advocate Christ Medical Center, Chicago.
Background: Calcineurin (CNI) nephrotoxicity is implicated in chronic allograft dysfunction and presents an argument for CNI minimizing immunosuppression. We assessed the long-term effects of CNI…
2018 American Transplant Congress
Graft Immunocomplex Capture Fluorescence Analysis Can Detect Intra-Graft Anti-Blood Group A/B Antibodies
T. Nakamura,¹ H. Ushigome,¹ Y. Imanishi,² S. Kawai,³ T. Shirouzu,³ M. Osaka,¹ K. Masuda,¹ T. Matsuyama,¹ S. Harada,¹ S. Nobori,¹ N. Yoshimura.¹
¹Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan; ²Department of Blood Transfusion and Cell Therapy, Kyoto Prefectural University of Medicine, Kyoto, Japan; ³Molecular Diagnostics Division, Wakunaga Pharmaceutical Co., Led, Hiroshima, Japan.
Background: Graft immunocomplex capture fluorescence analysis (ICFA) is an attractive method to detect intra-graft donor-specific anti-HLA antibodies (HLA-DSA). In ABO incompatible (ABOi) transplantation, anti-A/B antibodies…
2018 American Transplant Congress
Using the Remuzzi Score to Guide Single vs. Dual Transplantation Mitigates the Risk of Early Graft Failure
J. Ayorinde, G. Pettigrew.
Surgery, University of Cambridge, Cambridge, United Kingdom.
BackgroundExpanded criteria circulatory death donors (DCD) may represent an underutilised donor pool. Our centre has used urgent pre-implantation biopsy (Remuzzi score) to guide single (SKT)…
2018 American Transplant Congress
Donor Deficiency of RIP3 Phosphokinase Activity Shortens Cardiac Allograft Survival in the Setting of Costimulation Blockade
M. Zhu, K. Samy, L. Lin, J. Wang, L. Cendales, A. Kirk, A. Barbas, T. Brennan.
Surgery, Duke University, Durham, NC.
Receptor-interacting protein kinase 3 (RIP3) is critical for necroptosis in the setting of inflammation. It has been shown that kidney and heart allografts deficient in…
2018 American Transplant Congress
The Impact of Early versus Late Clinical Outcomes on Disparities in African-American Kidney Transplant Recipients
D. Taber, J. Fleming, Z. Su, P. Mauldin, J. McGillicuddy, S. Nadig, V. Rohan, P. Baliga, D. Dubay.
MUSC, Charleston, SC.
Background: It is important to better understand the impact of early and late clinical events on disparities in African-American (AA) kidney transplant (KTX), which will…
2018 American Transplant Congress
Long Term Outcomes of Renal Allografts with De Novo DSA in the Setting of Stable Graft Function versus Acute Rejection
R. Knight,¹ D. Nguyen,² E. Graviss,² T. Eagar,² S. Kuten,³ S. Patel,³ L. Moore,¹ A. Gaber.¹
¹Surgery, Houston Methodist Hospital, Houston, TX; ²Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX; ³Pharmacy, Houston Methodist, Houston, TX.
We sought to compare the long-term outcome of renal allograft recipients with de novo DSA (dnDSA) in the setting of stable allograft function versus dnDSA…
2018 American Transplant Congress
Donor Liver Apoptosis is Associated with Early Allograft Dysfunction and Short-Time Graft Survival after Liver Transplantation
Z. Guo, Z. Zhu, Y. Tang, S. Huang, Z. Zhang, X. He, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Aims The aim of the study was to determine whether donor liver apoptosis is predictive for early allograft dysfunction (EAD) and graft survival after liver…
2018 American Transplant Congress
Interferon-b Promotes Regulatory T Cell (Treg) Induction and Prolongs Allograft Survival
M. Fribourg,¹ M. McGinty,² A. Angeletti,² M. Demir,² S. Sealfon,¹ P. Heeger,² P. Cravedi.²
¹Neurology, Icahn School of Medicine at Mount Sinai, New York; ²Medicine, Translational Transplant Research Center, Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York.
Background: Interferon-b (IFNb), a type I interferon with antiviral and pro-inflammatory activity, has been used as an immune modulatory treatment of multiple sclerosis (MS). The…
2018 American Transplant Congress
Lower Uric Acid Level after Kidney Transplantation Impact on Better Long-Term Allograft Outcomes
D. Kim,¹ H. Choi,² Y. Jung,¹ J. Lee,¹ J. Lee,¹ J. Lee,¹ K. Huh,¹ M. Kim,¹ B. Kim,² Y. Kim.¹
¹Transplantation Surgery, Yonsei University Health System, Seoul, Korea; ²Nephrology, Yonsei University Health System, Seoul, Korea.
BackgroundIt has been on debate that hyperuricemia was an independent risk factor for poor prognosis in kidney transplantation. Considering the link of UA with diabetes,…
2018 American Transplant Congress
Standard Induction Immunosuppression Interferes with the Role of Vascularized Bone Marrow in Vascularized Composite Allograft Protection
N. Shockcor, E. Buckingham, W. Hassanein, A. Nam, S. Bartlett, R. Barth.
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.
Purpose: Clinical induction therapies have been demonstrated to interfere with the development of immunologic tolerance in experimental models. Vascularized bone marrow (VBM) has been demonstrated…