Articles tagged "Graft survival"

2018 American Transplant Congress
Memory T Cell Dysfunction after Pregnancy Alloimmunization Prolongs Transplant Survival
P. Porrett,¹ J. Cohen,² R. Xu,¹ E. Lewis,³ M. Elovitz,³ E. Wherry,⁴ D. Sawinski.²
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Medicine, University of Pennsylvania, Philadelphia, PA; ³OBGyn, University of Pennsylvania, Philadelphia, PA; ⁴Microbiology, University of Pennsylvania, Philadelphia, PA.
Background Pregnancy alloimmunization can preclude donor compatibility and may diminish transplant lifespan. While these consequences may be attributed to immunologic memory responses that endanger an…
2018 American Transplant Congress
Development of Denovo DSA after One Year Post Kidney Transplant and Clinical Outcomes in Patient on Steroid Free Immunosupression
A. Sharfuddin, M. Yaqub, D. Mishler, W. Goggins, T. Taber, O. Adebiyi.
Division of Renal Disease and Hypertension, Indiana University Health Transplant Program, Indianapolis, IN.
Background: Development of Denovo donor specific antibodies (DnDSA) has been associated with poor allograft outcomes in few studies. However, there is scarcity of data evaluating…
2018 American Transplant Congress
Lymphotoxin Beta Receptor Modulation in Lymphatic Endothelial Cells Alters Regulatory T Cell Dynamics
V. Saxena, W. Piao, Y. Xiong, L. Li, C. Wagner, J. Bromberg.
U Maryland, Baltimore, MD.
Background:Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels (LV)…
2018 American Transplant Congress
Sufficient Hepatic Artery Flow Redeems Poor Portal Vein Flow after Liver Transplantation in Patients with Porta Vein Thrombosis
L. Coromina Hernandez, K. Sasaki, D. Firl, J. McVey, M. Fujiki, F. Aucejo, B. Eghtesad, C. Quintini, C. Miller, K. Hashimoto.
General Surgery, Cleveland Clinic, Cleveland, OH.
Objective:Although portal vein thrombosis(PVT) in liver transplantation is no longer a contraindication, it remains technically challenging. Insufficient intraoperative PV flow after PV thrombectomy/reconstruction was reported…
2018 American Transplant Congress
Combined Heart–Kidney Compared to Isolated Heart Transplant in Patients with Chronic Kidney Disease – A Single Center Experience
D. Gauvin, A. Bhalla, W. McCallum, A. Vest, N. Goyal.
Tufts University School of Medicine, Boston, MA.
Background: Severe irreversible renal dysfunction has been a contraindication for heart transplant (HTx); however, combined heart-kidney transplant (HKTx) is an accepted therapeutic option for concomitant…
2018 American Transplant Congress
Rapamycin Therapy Impairs Treg Expression of CXCR3 and Limits Treg-Dependent Survival of Vascularized Composite Allotransplants
H. Xu,¹ Z. Chen,² W. Hancock,^3,4 S. Levin,⁵ Y. Zhang.¹
¹Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Medicine School of Shanghai Jiaotong University, Shanghai, China; ²Institute of Immunology, University of Pennsylvania, Philadelphia; ³Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia; ⁴Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia; ⁵Orthopaedic Surgery and Plastic Surgery, Hospital of the University of Pennsylvania, Philadelphia.
Vascularized Composite Allotransplantation (VCA) is a procedure to restore limb function or facial appearance. Rapamycin is used in efforts to preserve host Treg function and…
2018 American Transplant Congress
Outcomes of Early Steroid Withdrawal in 6-Antigen Human Leukocyte Antigen (HLA)-Matched Kidney Transplant Recipients
H. Champion, K. Holdener, B. Astor, F. Aziz, D. Mandelbrot.
UW Health, Madison, WI.
Background: Steroids are often used as part of standard immunosuppressant therapy to help prevent acute rejection in renal transplant patients. However, the long term adverse…
2018 American Transplant Congress
Comparison of Outcomes in African-American and White Primary Kidney Transplant Recipients: A Matched-Pair Analysis
F. Tedla, A. Brar, D. John, N. Sumrani, R. Gruessner, A. Gruessner, M. Salifu.
SUNY Downstate Medical Center, Brooklyn, NY.
Background: Racial differences in clinical and sociodemographic characteristics have been well recognized. This study aims to assess outcomes in African-American (AA) and white primary deceased…
2018 American Transplant Congress
Clinical Outcomes of HIV-Infected Kidney Transplant Recipients Managed with an Early Corticosteroid Withdrawal Protocol
A. Al Jurdi, E. Liu, M. Aull, M. Lubetsky, D. Serur, S. Kapur, T. Muthukumar.
Weill Cornell Medicine / New York Presbyterian Hospital, New York.
AimAssess the clinical outcomes of HIV-infected kidney transplant recipients managed with an early corticosteroid withdrawal protocol.MethodsSingle center chart review of HIV-infected kidney recipients between 2006…
2018 American Transplant Congress
Feasibility of a National Class II Matching Strategy for Pediatric Kidney Transplant Candidates
T. Blydt-Hansen,¹ W. Klement,² K. Tinckam,³ J. Gill.¹
¹University of British Columbia, Vancouver, Canada; ²Canadian Blood Services, Ottawa, Canada; ³University of Toronto, Toronto, Canada.
Antibody-mediated rejection (AMR) is a major concern for allograft failure, which could be mitigated by allocation of Class II matched donors. Since children have priority,…