Articles tagged "Graft survival"

2018 American Transplant Congress
Donor Plasma Mitochondrial DNA Predicts Post-Transplant Renal Allograft Outcomes
F. Han,¹ S. Wan,² N. Chen,² L. Zheng,³ N. Zhang,⁴ Q. Sun,¹ H. Li,¹ Z. Huang,¹ L. Hong,¹ Q. Sun.¹
¹Kidney Transplantation, Sun Yat-sen University, Guangzhou, China; ²Laboratory of Cancer Biomarkers and Liquid Biopsy, Henan University, Henan, China; ³Department of Medical Statistics and Epidemiology, Sun Yat-sen University, Guangzhou, China; ⁴Department of Pathology, Sun Yat-sen University, Sun Yat-sen, China.
The lack of an accurate biomarker makes it difficult to determine whether an organ is acceptable for transplantation. Mitochondrial DNA (mtDNA) correlates with tissue damage…
2018 American Transplant Congress
Prevalence, Risk Factors and Impact of BK Viremia on Kidney Transplantation: Single Center Experience
W. Hassan, A. El-Husseini, B. Suleiman, K. Wang, M. Yaseen, A. Maibam, A. Karim, A. Hines, A. Castellanos, V. Cornea, X. Mei, R. Gedaly, T. Waid.
Nephrology, University of Kentucky, Lexington, KY.
Introduction: BK viremia (BKV) is an emerging problem in renal transplantation. The risk factors and the impact of BKV on renal allograft and patient survival…
2018 American Transplant Congress
Donor Specific Antibodies and Clinical Outcomes in Kidney Transplant Recipients
S. Wan,^1,2 S. Chadban,^1,2 K. Wyburn.^1,2
¹Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ²Sydney Medical School, University of Sydney, Sydney, Australia.
BACKGROUND: Donor specific antibodies (DSA) have been implicated in the development of acute rejection (AR) and graft dysfunction in kidney transplant recipients (KTx). However, limited…
2018 American Transplant Congress
Impact of Donor Age on Outcomes after Living Donor Liver Transplantation
K. Hayashi,¹ K. Gotoh,¹ H. Eguchi,¹ Y. Iwagami,¹ D. Yamada,¹ T. Asaoka,¹ T. Noda,¹ K. Kawamoto,¹ S. Kobayashi,¹ K. Umeshita,² Y. Doki,¹ M. Mori.¹
¹Dept of Gastroenterological Sugery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan; ²Division of Health Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Background: Liver transplantation (LT) is a curative treatment for decompensated cirrhosis and fulminant hepatitis. Although not a few patients received LT with marginal donor livers…
2018 American Transplant Congress
Treatment Outcomes of Recurrent Primary Focal Segmental Glomerulosclerosis (FSGS) after Kidney Transplantation
R. Aguiar,¹ F. Pereira,² A. Gasparini,³ P. Chowdhury,¹ D. Game,¹ D. Moutzouris.¹
¹Department of Nephrology and Transplantation, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom; ²Department of Renal Medicine, Hospital Dr. Fernando Fonseca, Lisbon, Portugal; ³Department of Health Sciences, University of Leicester, Leicester, United Kingdom.
Introduction: Primary FSGS can recur in the renal allograft and is associated with poor graft outcomes. There is no established therapeutic intervention to prevent or…
2018 American Transplant Congress
Improved Renal Allograft Survival for Pre-Emptive Paediatric Renal Transplant Recipients in the United Kingdom
M. Marlais,¹ K. Martin,² S. Marks.¹
¹Paediatric Nephrology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom.
OBJECTIVESThe aim of this study was to investigate whether being on dialysis at the time of renal transplantation affected renal allograft survival in paediatric renal…
2018 American Transplant Congress
How Safe is Crossing the ABO Blood Group Barrier? A Meta-Analysis to Determine the Additive Risk of ABO-Incompatible Kidney Transplantation
A. de Weerd, M. Betjes.
Nephrology and Kidney Transplantation, Erasmus Medical Center, Rotterdam, Netherlands.
Background ABO blood group-incompatible (ABOi) kidney transplantation is considered a safe procedure, with non-inferior outcomes in large cohort studies. Its contribution to living kidney transplantation…
2018 American Transplant Congress
Ablation of Both mTOR and STAT3 in T Cells Induces Heart Transplant Acceptance in Donor Skin-Sensitized Mice
A. Xie,^1,2 W. Chen.^2,3
¹Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Center for Immunobiology and Transplantation Research, Houston Methodist Research Institute, Houston, TX; ³Department of Surgery, Weill Cornell Medical College of Cornell University, New York, NY.
Allogeneic memory T cell response precludes the induction of transplant acceptance; how this process is regulated at the molecular level remains unclear. Both mTOR and…
2018 American Transplant Congress
Hyaluronic Acid as Early Biomarker of Graft Loss after Liver Transplantation: A Prospective Study
A. Rostved,¹ S. Ostrowski,² L. Peters,³ J. Lundgren,³ C. Sørensen,¹ H-.C. Pommergaard,¹ J. Hillingsø,¹ A. Rasmussen.¹
¹Department of Surgical Gastroenterology and Transplantation, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; ²Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; ³CHIP, Department of Infectious Diseases, Section 2100, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Introduction: Improved diagnosis and understanding the pathophysiology of early allograft dysfunction is essential to improve the short-term outcome after liver transplantation (LT). Hyaluronic acid (HA)…
2018 American Transplant Congress
Experience with Alemtuzumab Induction with Tacrolimus/Mycophenolate +/- Steroids in Simultaneous Pancreas-Kidney Transplant Recipients with Portal-Enteric Drainage
D. Harriman, A. Farney, J. Rogers, G. Orlando, A. Reeves-Daniel, M. Gautreaux, W. Doares, S. Kaczmorski, R. Stratta.
Surgery, Medicine, Pathology, Pharmacy, Wake Forest Baptist Medical Center, Winston-Salem, NC.
Introduction: Simultaneous pancreas-kidney transplant (SPKT) recipients are a relatively homogeneous population that are considered high immunological risk because of younger age, presumed autoimmune etiology of…