2018 American Transplant Congress
Impact of Direct Acting Antiviral Agents (DAAs) for Hepatitis C Virus (HCV)-Induced Liver Diseases on Registration and Outcome on Waiting List (WL) for Liver Transplant (LT)
2d-generation DAAs have dramatically improved the management of patients with HCV, including patients with advanced diseases. In France, since 2013, DAA have been largely used,…2018 American Transplant Congress
Digital-Enabled Refills and Medication Adherence among Transplant Recipients
Purpose: Impact of nonadherence among transplant recipients has been well documented as a significant contributor of allograft failure. The objective of this study was to…2018 American Transplant Congress
Ex Vivo-Expanded Human CD19+CD73–CD25+CD71+TIM-1+ B Regulatory Cells Can Prolong Allograft Survival in a Humanized Mouse Model of Skin Transplantation and Are Dependent on TIM-1-Mediated Regulation of STAT3 Signaling
The importance of B regulatory cells (Breg) in both health and disease has rapidly become evident over the last decade. Breg are able to control…2018 American Transplant Congress
The Impact of Pre-Transplant Donor Specific Antibodies (DSA) on AMR Rates in HIV-Infected Kidney Transplant Recipients Inducted with IL-2 RA
Recanati Miller Transplant Institute, Icahn School of Medicine at Mt. Sinai, New York, NY.
Background: 1-year rejection rates in HIV-infected kidney transplant recipients range from 15-40%, compared to overall rejection rates of 10% in HIV-negative patients. We report the…2018 American Transplant Congress
Lymph Node Reprogramming: Microparticle Delivery of Immune Signals to Induce Tolerance and Prolong Allograft Survival
Introduction: Microparticle (MP) loaded with peptide antigen plus other immune signals and delivered directly into lymph nodes (LN) can result in either pro-inflammatory or anti-inflammatory…2018 American Transplant Congress
A Long-Term Experience with Expansion of Milan Criteria for Liver Transplant Recipients
1Duke University, Durham, NC; 2Baylor College of Medicine, Houston, TX.
Background: The Milan Criteria (MC) have historically determined eligibility for transplantation for hepatocellular carcinoma (HCC). The United Network for Organ Sharing (UNOS) Region 4 expanded…2018 American Transplant Congress
10-Year Outcomes of Renal Transplantation from Circulatory Death Donors with Increased Terminal Creatinine
Surgery III, Tokyo Women's Medical University, Tokyo, Japan.
Background: To alleviate chronic renal graft shortages in Japan, donation after circulatory death (DCD) is an increasingly used organ resource. Organs from DCD donors with…2018 American Transplant Congress
TLR-Activated Bregs Promote Islet Allograft Tolerance in an IL-10-Independent and TGF-β-Dependent Manner
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Background: We previously demonstrated the potent capacity of regulatory B cells (Bregs) to mitigate allograft immunity. Recently, we produced TLR-activated B cells in vitro that…2018 American Transplant Congress
Complement Activating HLA Class 2 Antibodies Are Associated with Poor Renal Allograft Survival; Multicentre Study
IntroductionRole of Class I and II pre-formed complement activating antibodies on renal outcomes is not well defined. In this multicentre study, we looked at the…2018 American Transplant Congress
ACEI/ARB Use within One Year of Kidney Transplant is Associated with Less AKI and Graft Loss in Older Recipients
Medical University of South Carolina, Charleston, SC.
As short-term outcomes have improved, optimizing long-term graft survival remains a major focus of transplant programs. Older kidney transplant recipients are particularly vulnerable to acute…
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