Articles tagged "Graft survival"

2018 American Transplant Congress
Impact of De Novo DSA Development and Management on Kidney Transplant Outcomes
M. Cote,¹ M. Pavlakis,² F. Cardarelli,² J. Pena,³ A. Dinh,³ K. Richards,¹ K. Joyal,¹ C. Rogers.¹
¹Pharmacy, Beth Israel Deaconess Medical Center, Boston, MA; ²Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA; ³Pathology, Beth Israel Deaconess Medical Center, Boston, MA.
Multiple studies have shown that development of donor specific antibodies (DSAs) can have a negative impact on renal allograft outcomes resulting in decreased renal function,…
2018 American Transplant Congress
Effect of Belatacept on Late Acute Rejection Episodes and Graft Loss in Young Adults between the Ages of 18-24 Years: Post-Hoc Analysis of BENEFIT Study
A. Moudgil.
Nephrology, Children National Health System, Washington, DC.
Background: Recent data suggests higher incidence of late acute rejection (LAR) in young adults (18-24 years of age) causing graft loss just like adolescents due…
2018 American Transplant Congress
Transplanting Kidneys from HCV-Infected Donors into HCV-Negative Recipients: Longer-Term and Extended Results of the THINKER Trial
D. Goldberg,¹ E. Blumberg,¹ P. Abt,¹ M. Levine,¹ P. Porrett,¹ A. Naji,¹ S. Nazarian,¹ D. Sawinski,¹ J. Trofe-Clark,¹ V. Van Deerlin,¹ C. Gentile,¹ J. Smith,¹ M. Kaminski,¹ A. Sicilia,¹ R. Hasz,² L. Suplee,² R. Reddy,¹ R. Bloom,¹ P. Reese.¹
¹University of Pennsylvania, Philadelphia; ²Gift of Life, Philadelphia.
Background: In 2016, 800 kidneys from HCV+ deceased donors were discarded. Short-term (6-month) data from the first 10 subjects in the THINKER-1 trial (NCT02743897; funder:…
2018 American Transplant Congress
Livers from Donation after Circulatory Death Donors Can Be Safely Used for Retransplantation
O. van Leeuwen,¹ M. van Reeven,² J. Erdmann,³ H. Metselaar,⁴ A. van den Berg,⁵ B. van Hoek,⁶ W. Polak,² R. Porte.¹
¹Department of Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Department of Surgery, Erasmus Medical Center, Rotterdam, Netherlands; ³Department of Surgery, Leiden University Medical Center, Leiden, Netherlands; ⁴Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands; ⁵Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Netherlands; ⁶Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands.
Introduction: After donation after circulatory death (DCD) liver transplantation (LT), non-anastomotic biliary strictures (NAS) and early allograft dysfunction (EAD) are more frequently observed than after…
2018 American Transplant Congress
Should More Donation after Cardiac Death Livers Be Used in Pediatric Transplantation?
C. Hwang,¹ S. Levea,² M. MacConmara.¹
¹Surgery, UT Southwestern Medical Center, Dallas, TX; ²Medicine, UT Southwestern Medical Center, Dallas, TX.
Introduction: Multiple strategies exist to increase the organ pool for livers in pediatric recipients, including using split livers, high risk livers, and donation after cardiac…
2018 American Transplant Congress
Urinary C5b-9 is an Independent Predictor of Graft Failure in Renal Transplant Recipients
R. Lammerts, M. Eisenga, M. Alyami, M. Seelen, M. Daha, J. van den Born, S. Bakker, S. Berger, On behalf of the COMBAT Comsortium.
Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands.
IntroductionChronic antibody-mediated rejection is thought to be the main cause of late kidney-allograft loss, involving donor-specific antibody–mediated activation of the complement system. Activation of filtered…
2018 American Transplant Congress
Histone Deacetylase-6 Inhibition Mitigates Liver Ischemia-Reperfusion Injury and Acetaminophen Toxicity in Mice
S. Concors,¹ D. Murken,¹ D. Aufhauser,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,⁴ W. Hancock,^3,4 M. Levine.^1,2
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Surgery, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA; ⁴Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.
Introduction: Ischemia/reperfusion injury (IRI) leads to poor outcomes and early graft loss in liver transplantation. Understanding the mechanisms of liver IRI may aid in prevention…
2018 American Transplant Congress
The Effect of Steroid Maintenance in Recipients with Pancreas Transplant Alone: A Single Center Experience
J. Choi, J. Jung, H. Kwon, S. Shin, Y. Kim, D. Han.
Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University Ulsan College of Medicine, Seoul, Korea.
Background: In solid organ transplantation, the use of steroids for maintenance therapy is common. However, the appropriateness of steroid maintenance or withdrawal in pancreas transplantation…
2018 American Transplant Congress
Long-Term Outcome of Pediatric Kidney Transplantation: A Single-Center Experience over the past Three Decades in Japan
Y. Aoki,¹ H. Satoh,¹ Z. Matsui,¹ R. Hamada,² Y. Hamasaki,³ S. Shishido.³
¹Urology and Kidney Transplantation, Tokyo Metropolitan Children's Medical Center, Fuchu-shi, Tokyo, Japan; ²Nephrology, Tokyo Metropolitan Children's Medical Center, Fuchu-shi, Tokyo, Japan; ³Nephrology, Toho University Faculty of Medicine, Ota-ku, Tokyo, Japan.
Purpose: Kidney transplantation (KTx) is the preferred treatment for children with ESRD. Although the steady advances in immunosuppression have enabled control of early acute rejection…
2018 American Transplant Congress
National Outcomes of Donor and Recipient Sex Mismatch in Kidney Transplantation
J. Buggs,¹ L. Wang,³ R. Liu,³ E. Rogers,² V. Bowers.¹
¹Transplant Surgery, Tampa General Medical Group, Tampa General Hospital, Tampa, FL; ²Transplant Research, Tampa General Hospital, Tampa, FL; ³Molecular Pharmacology & Physiology, University of South Florida, Tampa, FL.
Introduction: Gender Outcomes remain controversial in solid organ transplantation.Aim: The study aim was to evaluate the outcomes of sex mismatched donors and recipients where a…