ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft survival"

  • 2019 American Transplant Congress

    Laminin α5 Deficiency in Lymph Node Stromal Cells Promotes Treg Migration and Allograft Survival

    L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, T. Simon, N. Toney, C. Paluskievicz, J. S. Bromberg

    Surgery, U. Maryland, Baltimore, Baltimore, MD

    *Purpose: Laminins are a family of heterotrimeric glycoproteins, and lymph node (LN) stromal laminins α4 and α5 modulate suppression and immunity, respectively. We created laminin…
  • 2019 American Transplant Congress

    Change in Estimated Glomerular Filtration Rate and Risk of Allograft Failure in Patients Diagnosed with Active Antibody-Mediated Rejection Following Kidney Transplantation

    W. Irish1, P. Nickerson2, B. Astor3, E. Chong4, C. Wiebe2, F. Moreso5, D. Seron5, M. Crespo5, L. Gache6, A. Djamali3

    1East Carolina University, Greenville, NC, 2University of Manitoba, Winnipeg, MB, Canada, 3University of Wisconsin, Madison, WI, 4Vitaeris, Inc, Vancouver, BC, Canada, 5University Hospital Vall d'Hebron, Barcelona, Spain, 6CTI Clinical Trial & Consulting, Covington, KY

    *Purpose: There are challenges in designing an adequate and well-controlled study of patients with active antibody-mediated rejection (ABMR), especially in the absence of a valid…
  • 2019 American Transplant Congress

    miRNA Signatures as Prediction Tool for DSA Development and Rejection

    M. Hamdorf1, L. M. Rebellato2, K. P. Briley2, M. J. Everly1

    1Terasaki Research Institute, Los Angeles, CA, 2East Carolina University, Greenville, NC

    *Purpose: Early and convenient diagnosis is urgently needed for acute and chronic transplant rejection due to its high risk of the loss of the transplant.…
  • 2019 American Transplant Congress

    Desensitization Using Only Polyvalent Immunoglobulins (IVIG) for Kidney Transplantation with Living Donors (LD)

    L. R. Ulisses, J. O. Paixão, P. S. Souza, G. Bezerra, H. Rodrigues, N. Panajatopoulos, F. J. De Paula, E. David-Neto, M. C. R Castro

    Renal Transplant Service, Renal Transplant Service, Hospital das Clinicas and Laboratory of Immunology-LIM-19, Medical School of te University of São Paulo, São Paulo, Brazil, São Paulo, Brazil

    *Purpose: HLA sensitization is a barrier for kidney transplantation. Sensitized patients stay longer on the waiting list and have higher mortality rate and complications while…
  • 2019 American Transplant Congress

    Outcome of Renal Transplantation in Systemic Amyloidosis

    S. Law1, L. Helen2, T. Resk2, A. Wechalekar2, J. Gillmore2, R. Motallebzadeh1

    1Renal Medicine, Royal Free Hospital, London, United Kingdom, 2UCL Division of Medicine, National Amyloidosis Centre, London, United Kingdom

    *Purpose: Systemic amyloidosis accounts for approximately 0.8% of end stage renal disease (ESRD) in the UK. Outcomes following renal transplantation in systemic amyloidosis were historically…
  • 2019 American Transplant Congress

    Late Onset J C Virus Allograft Nephropathy

    M. Samra, I. Tang, S. Setty

    University of Illinois Health, Chicago, IL

    *Purpose: JC virus(JCV) is a member of the Polyomaviridae family. Few studies have been published regarding the replication of JCV in transplant recipients. The incidence…
  • 2019 American Transplant Congress

    Inhibition of Th1 and Th17 Cell Differentiation and Prolonged Graft Survival through NFAT Pathway Downregulation

    C. Dai1, R. Tan1, B. Yang1, J. Markmann2, D. Chen1, L. Wei1, Z. Chen1

    1Institute of Organ Transplantation, Wuhan, China, 2Division of Transplantation, Boston, American Samoa

    *Purpose: Extracts Aglaia (family Meliaceae) plants, specially Rocaglamide are used treatment strategy of autoimmune Inflammatory disease and allergic disease in traditional medicine in many Asia…
  • 2019 American Transplant Congress

    The Important Roles of Dendritic Cells in Transplantation

    T. Ueno1, M. M. McGrath1, M. Y. Yeung1, S. Cai1, Y. Ueno1, T. Yokoyama2, Y. Kihara2, O. Konno2, Y. Nakamura2, H. Iwamoto2, A. K. Chandraker1

    1Medicine, Renal Division, Brigham and Women's Hospital, Transplantation Research Center, Boston, MA, 2Kidney Transplantation Surgery, Tokyo Medical University, Hachioji Medical Center, Tokyo, Japan

    *Purpose: The interplay between dendritic cells (DCs) and T cells plays a central role in the process of allograft rejection. Upon antigen exposure, positive costimulatory…
  • 2019 American Transplant Congress

    Have Graft Outcomes Improved for Pediatric Transplant Recipients Since the Implementation the Kidney Allocation System

    C. S. Bell1, S. Hebert2, A. De Golovine3, R. Swinford1

    1Division of Pediatric Nephrology & Hypertension, McGovern Medical School at UTHealth - Houston, Houston, TX, 2Division of Nephrology, Department of Internal Medicine, Houston Methodist Hospital, Houston, TX, 3Renal Diseases &Hypertension, McGovern Medical School at UTHealth - Houston, Houston, TX

    *Purpose: The new kidney allocation system (KAS) that utilizes a Kidney Donor Profile Index (KDPI) in matching transplant recipients to donors was implemented in December…
  • 2019 American Transplant Congress

    The Protective Effects of siRNA Conjugated Nanoparticles in Pancreatic Islet Cells after Transplant

    T. Pomposelli, P. Wang, Y. Ariyoshi, K. Takeuchi, C. Schuetz, A. Moore, K. Yamada

    Columbia Center for Translational Immunology, Columbia University, New York, NY

    *Purpose: To utilize a novel technology involving siRNA conjugated iron oxide nanoparticles to protect against ischemic damage to islet cells before transplant, therefore minimizing the…
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