Articles tagged "Graft survival"

2019 American Transplant Congress
Undernutrition and Leptin Deficiency Modulates T Cell Immunity in Transplantation
E. David¹, M. Zhu², B. Bennett², D. Cheng¹, A. Nichols¹, W. Parker², P. Schroder², N. McIver¹, A. Kirk², E. Chambers¹
¹Pediatrics, Duke University, Durham, NC, ²Surgery, Duke University, Durham, NC
*Purpose: We have previously shown an association between undernutrition and the development of viremia in transplanted children. While undernutrition is associated with impaired T cell…
2019 American Transplant Congress
B Cell IL-4 Signaling Induces the IL-10 Secreting TIM-1+ Bregs and Suppresses T Cell Inflammatory Cytokines
Z. Song, K. Mohib, D. M. Rothstein
Surgery, Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: TIM-1+ identifies the majority (~75%) of IL-10+ B regulatory cells (Bregs). However, TIM-1+ B cells are also enriched for IL-4+ B effector 2 cells…
2019 American Transplant Congress
Social Loafing: Distribution of Kidneys with Multiple Renal Arteries in a National Paired Kidney Exchange Program
G. R. Roll¹, W. Irish², M. Cooper³, M. Ronin⁴, G. Hil⁴, A. D. Waterman⁵, D. B. Leeser²
¹UCSF, San Francisco, CA, ²ECU, Greenville, NC, ³Georgetown Univ, Washington, DC, ⁴NKR, Babylon, NY, ⁵UCLA and Terasaki Research Institute, Los Angeles, CA
*Purpose: To describe the distribution and outcomes after kidney transplantation of multiple renal artery kidneys (MRAK) in a national exchange program.*Methods: We retrospectively reviewed donor…
2019 American Transplant Congress
Long Term Outcomes in Kidney Transplant Recipients Receiving Everolimus (EVR) or Mycophenolate (MPS) in Combination with Tacrolimus (TAC)
K. Ficher, C. Rosso Felipe, Y. Cardoso Dreige, K. Linhares, A. Ferreira Brígido, S. Stopa, L. Viana, M. Cristelli, P. Gessolo Lins, W. Aguiar, H. Proença, R. Marco, M. Gerbase de Lima, H. Tedesco Silva Junior, J. Medina Pestana
Hospital do Rim, Nephrology Division, EPM - UNIFESP, São Paulo, Brazil
*Purpose: Detailed long-term data comparing the use of EVR or MPS in kidney transplant recipients receiving TAC is lacking.*Methods: This is a 5-years extension analysis…
2019 American Transplant Congress
Absence of Non Alcoholic Fatty Liver Disease in Allografts from Morbidly Obese Donors: A Marker for Success?
M. MacConmara, A. Mufti, S. Hanish, T. Kerr, P. Vagefi, C. Hwang
Surgery (Division of Surgical Transplantation), UT Southwestern, Dallas, TX
*Purpose: Livers from African-American, morbidly obese donors are less likely to be discarded. We examined the utility of pre-recovery liver biopsy as a predictive biomarker…
2019 American Transplant Congress
Type of Induction Does Not Impact Patient or Kidney Allograft Survival in Simultaneous Liver and Kidney Transplant Recipients in the United States
S. Riad¹, N. Lim², S. Jackson³, J. Lake²
¹University of Minnesota, Minneapolis, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³Complex Care Analytics, Fairview Health Services, Minneapolis, MN
*Purpose: Induction practices vary widely in the United States for patients undergoing simultaneous liver and kidney (SLK) transplantation. We examined the impact of induction type…
2019 American Transplant Congress
The Role of Recipient Weight in Renal Transplantation Revisited; Not Quite the Obesity Paradox
A. Asderakis, R. Tahawar, T. Sabah, U. Khalid, M. Stephens
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom
*Purpose: Studies conflict whether obesity is associated with higher risk of failure and death among kidney transplant recipients. ESRF patients show the obesity paradox where…
2019 American Transplant Congress
Risk Factors for Graft Loss Vary with Recipient MELD Score in Liver Transplantation
J. A. Steggerda¹, M. B. Bloom¹, T. Todo², T. V. Brennan², N. N. Nissen², A. S. Klein², I. K. Kim²
¹Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA, ²Transplant Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA
*Purpose: Risk factors for allograft loss in liver transplantation have previously been described. Less is known how these vary and interact amongst recipients with different…
2019 American Transplant Congress
Kidney Transplant Outcomes in Recipients with Physical Impairments
A. G. Thomas¹, J. Ruck², N. Chu², D. Agoons², A. Shaffer², C. Haugen², H. Ying², B. Swenor², S. Norman³, J. Garonzik-Wang², D. Segev², M. McAdams-DeMarco²
¹Epidemiology, UNC Chapel Hill, Chapel Hill, NC, ²Johns Hopkins University, Baltimore, MD, ³University of Michigan, Ann Arbor, MI
*Purpose: Disability in general has been associated with poor outcomes in KT recipients. However, disability can be derived from various components, specifically visual, hearing, physical,…
2019 American Transplant Congress
Allograft Survival is Influenced by Gut Microbiota-Dependent Modulation of Innate Immunity
V. Saxena¹, Y. Xiong¹, L. Hittle¹, L. Li¹, T. Simon², W. Piao¹, C. C. Brinkman¹, E. M. Smyth¹, T. Zhang¹, C. Wagner¹, C. M. Palusckievicz¹, W. F. Fricke³, E. F. Mongodin¹, J. S. Bromberg¹
¹U Maryland, Baltimore, MD, ²Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, CNRS, Valbonne, France, ³Institute of Biological Chemistry and Nutrition, U Hohenheim, Stuttgart, Germany
*Purpose: The gut microbiota driven inflammatory response and the host immune system engage bidirectional regulation of each other. These interactions are poorly characterized in organ…