Articles tagged "Graft survival"

2019 American Transplant Congress
Toll Like Receptor 2 Mobilizes Regulatory T Cell Lymphatic Migration by Stimulating Lymphotoxin Expression
W. Piao¹, Y. Xiong², L. Li³, V. Saxena³, C. Paluskievicz³, J. Bromberg⁴
¹Microbiology and Immunology, U. Maryland, Baltimore, baltimore, MD, ²Surgery, U. Maryland, Baltimore, baltimore, MD, ³Surgery, U. Maryland, Baltimore, Baltimore, MD, ⁴Surgery and Microbiology and Immunology, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Regulatory T cell (Treg) afferent lymphatic migration is important for islet allograft survival. Treg express high levels of lymphotoxin (LT) and bind the LT…
2019 American Transplant Congress
Kidney Paired Donation Transplant Outcomes: Experiences from the First Ten Years of the National Kidney Registry
D. B. Leeser¹, A. G. Thomas², A. A. Shaffer², J. Veale³, A. B. Massie², M. Cooper⁴, S. Kapur⁵, S. Kapur⁵, S. Kapur⁵, N. Turgeon⁶, D. Segev², A. Waterman³, S. Flechner⁷
¹East Carolina Univ Sch of Med, Greenville, NC, ²Johns Hopkins, Baltimore, MD, ³UCLA, Los Angeles, CA, ⁴Georgetown, Washington, DC, ⁵Weill Cornell Medical School, New York, NY, ⁶Emory, Atlanta, GA, ⁷Cleveland Clinic, Cleveland, OH
*Purpose: In the United States (US), kidney paired donation (KPD) networks have facilitated an increasing proportion of KTs annually, but longer-term transplant outcomes and differences…
2019 American Transplant Congress
Tacrolimus Concentration/Dose Ratio is an Independent Predictor of Death-Censored Kidney Allograft Survival
T. Jouve¹, J. Noble¹, X. Fonrose², B. Janbon¹, G. Fiard³, P. Malvezzi¹, L. Rostaing¹
¹Nephrology, Dialysis, Aphereses and Transplantation Department, Grenoble University Hospital, Grenoble, France, ²Pharmacology, Pharmacogenetics and Toxicology Laboratory, Grenoble University Hospital, Grenoble, France, ³Urology and Kidney Transplantation Department, Grenoble University Hospital, Grenoble, France
*Purpose: Tacrolimus (Tac) remains the cornerstone of kidney transplantation immunosuppression. Its narrow therapeutic index demands therapeutic drug monitoring. The C/D ratio (Tac trough concentration /…
2019 American Transplant Congress
Use of Anti-Vimentin Antibodies as a Possible Marker for Graft Dysfunction Following Renal Transplant, a Prospective Study
E. Acosta¹, T. Divanyan¹, D. Patel¹, F. Jourd'heuil², D. Jourd'heuil², R. Lopez-Soler³
¹Albany Medical College, Albany, NY, ²Molecular and Cellular Physiology, Albany Medical College, Albany, NY, ³Surgery, Section of Transplantation, Albany Medical College, Albany, NY
*Purpose: In our previously published work, we showed that presence of anti-vimentin antibodies (AVA) after renal transplant correlated with early IFTA (Interstitial Fibrosis and Tubular…
2019 American Transplant Congress
Living Donor Renal Transplantation without Any Induction Immunosuppression in Spousal Donors – Single Center Experience
R. Bhat, F. Aziz, I. N. Abubecker, S. Narayanan, B. Hafeeque
Nephrology & Transplantation, Malabar Instiute of Medical Sciences, Calicut, India
*Purpose: Renal transplantation in India is primarily driven by living related donation; parents and spouse constitute 70% of donors in India. Some centres use induction…
2019 American Transplant Congress
Development of a Recurrence Risk Score in IgA Nephropathy after Kidney Transplantation: Role of Recipient Age and HLA-B Mismatch
L. M. Rodas Marin¹, E. Ruiz², A. García³, M. Blasco¹, P. Ventura¹, E. de Soussa¹, O. Viñas⁴, F. Diekmann¹, L. Quintana¹
¹Nephrology and Renal Trasplantation, Hospital Clinic, Barcelona, Spain, ²Immunology, Hospital Clinic, Barcelona, Spain, ³Pathology, Hospital Clinic, Barcelona, Spain, ⁴Inmunology, Hospital Clinic, Barcelona, Spain
*Purpose: Recurrence of IgA nephropathy is an important and growing cause of kidney allograft dysfunction. The purpose of this observational retrospective study was to characterize…
2019 American Transplant Congress
The Utility Of Intraoperative Vascular Anastomotic Inflow Measurements In Donation After Circulatory Death (DCD) Liver Transplantation
A. Nair, L. Coromina Hernandez, K. Sasaki, C. Kwon, T. Diago Uso, M. Fujiki, F. Aucejo, K. Hashimoto, B. Eghtesad, C. Miller, C. Quintini
Cleveland Clinic, Cleveland, OH
*Purpose: The use of flow probes to measure hepatic inflow at the conclusion of vascular anastomoses in Donation after Circulatory Death (DCD) liver transplantation is…
2019 American Transplant Congress
Laminin Dependent T Cell Migration Determines Allograft Survival
L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, B. M. Cerel, C. Paluskievicz, J. S. Bromberg
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Differential expression of lymph node (LN) stromal laminins α5β1γ1 (511) and α4β1γ1 (411) is associated with tolerance and immunity, respectively. We investigated the hypothesis…
2019 American Transplant Congress
Increased Frequency of Myeloid-Derived Suppressor Cells Contributing to Prolong Skin Allograft Survival in Aged Mice
W. Lee, Y. Wang, T. Wu, C. Cheng, C. Lee, T. Wu, H. Chou, K. Chan
General Surgery, Chang-gung Hospital, Taoyuan, Taiwan
*Purpose: Currently, aged people are increasing and more and more aged people have organ transplantation. The immunity in aged people is weaker than young people.…
2019 American Transplant Congress
Population-Based Modeling of Prototypes and Determinants of Allograft Function Trajectories after Kidney Transplantation: Impact for Patient Monitoring and Risk Stratification
M. Raynaud¹, O. Aubert¹, M. Naesens², I. Juric³, N. Basic³, N. Kamar⁴, E. Huang⁵, S. Jordan⁵, B. Orandi⁶, D. Segev⁶, M. Stegall⁷, E. Morelon⁸, M. Giral⁹, E. Bailly¹⁰, E. Akalin¹¹, G. Gupta¹², M. Ladrière¹³, M. Buchler¹⁰, P. Reese¹⁴, C. Lefaucheur¹, A. Loupy¹
¹Paris, ., France, ²Leuven, ., Belgium, ³Zagreb, ., Croatia, ⁴Toulouse, ., France, ⁵Los Angeles, ., CA, ⁶Baltimore, ., MD, ⁷Rochester, ., MN, ⁸Lyon, ., France, ⁹Nantes, ., France, ¹⁰Tours, ., France, ¹¹New York, ., NY, ¹²Richmond, ., VA, ¹³Nancy, ., France, ¹⁴Philadelphia, ., PA
*Purpose: Although the current gold standard of kidney allograft patients monitoring relies on GFR assessment, little is known about long-term GFR trajectories prototypes and their…