Articles tagged "Graft survival"

2019 American Transplant Congress
MELD Score and Anti-Angiotensin Receptor Antibody Predict Long-Term Survival of Liver Re-Transplant
Q. Xu¹, A. Skaro², V. C. McAlister²
¹Pathology and Lab Medicine, London Health Science Center, London, ON, Canada, ²Surgery, London Health Science Center, London, ON, Canada
*Purpose: Recent reports indicated important while inconsistent roles of preformed donor specific antibody (DSA) to HLA in liver transplantation. Re-transplant liver patients were understudied due…
2019 American Transplant Congress
Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy
D. Patel¹, T. Divanyan¹, E. Acosta¹, K. Carnes², D. Howard³, F. Jourd’heuil³, D. Jourd’heuil³, R. Lopez-Soler⁴
¹Albany Medical College, Albany, NY, ²Urology, Albany Medical College, Albany, NY, ³Molecular and Cellular Physiology, Albany Medical College, Albany, NY, ⁴Surgery, Section of Transplantation, Albany Medical College, Albany, NY
*Purpose: Although it is usually accepted that the kidney is prone to hypoxic injury, the importance of hypoxia in chronic kidney disease (CKD) as well…
2019 American Transplant Congress
Microvascular Rarefaction and Long-Term Graft Dysfunction in Kidney Transplant Recipients with Delayed Graft Function
A. Doreille, S. Larivière-Beaudoin, A. Karakeussian-Rimbaud, M. Hébert, M. Dieudé, N. Patey, H. Cardinal
1Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada
*Purpose: Delayed graft function (DGF), or acute kidney injury in the perioperative period, is associated with decreased kidney graft survival.*Methods: As animal studies suggest that…
2019 American Transplant Congress
A Retrospective Analysis Evaluating Various Tissue Biopsy Scoring Systems in Predicting Recipient Outcomes Following Transplantation of Extended Criteria Donor Kidneys
A. Hijazi¹, D. Nap¹, M. Gabril², M. Moussa², V. Ibrahim³, M. A. Levine⁴, M. Madruah⁴, P. Luke⁴, A. Sener⁴
¹Schulich School of Medicine and Dentistry, London, ON, Canada, ²Pathology, London Health Sciences Center, London, ON, Canada, ³Western University, London, ON, Canada, ⁴Urology, London Health Sciences Center, London, ON, Canada
*Purpose: Organ selectivity for transplantation can be quite challenging, especially for marginal kidneys. We examined the prognostic utility of the Maryland Aggregate Pathology Index (MAPI)…
2019 American Transplant Congress
The Inverted Renal CD4/CD8 Ratio Associated with the Development of Transplant Glomerulopathy and Arteriosclerosis
B. H. Ozdemir¹, F. N. Ozdemir², A. Ok Atılgan¹, E. Akcay¹, M. Haberal³
¹Pathology, Baskent University, Ankara, Turkey, ²Nephrology, Baskent University, Ankara, Turkey, ³Transplantation, Baskent University, Ankara, Turkey
*Purpose: Inversion of the CD4/CD8 ratio (
2019 American Transplant Congress
Long-term Impact of Antihypertensive Treatment and Tacrolimus Dose in Renal Allograft Recipients 5 Years Post-Transplantation
D. Rush¹, S. Cockfield², S. Wilson³, J. Schwartz⁴
¹University of Manitoba, Winnipeg, MB, Canada, ²University of Alberta Hopspital, Edmonton, AB, Canada, ³Astellas Pharma Global Development, Northbrook, IL, ⁴Astellas Pharma US, Northbrook, IL
*Purpose: Inflammation and fibrosis after renal transplantation may be modulated by optimizing tacrolimus exposure, or by use of angiotensin-converting enzyme inhibitors (ACEi), or angiotensin receptor…
2019 American Transplant Congress
Pre-emptive Ivig For Dsa Positive Living Donor Kidney Transplant Recipients
B. Abdalla¹, D. Kellner², A. Diaz², Y. Zheng³, E. Reed⁴, Q. J. Zhang⁴
¹Medicine, Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²David Geffen School of Medicine at UCLA, Los Angeles, CA, ³UCLA Immunogenetics Center, Los Angeles, CA, ⁴Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Intravenous immunoglobulin (IVIG) is used in desensitization regimens to modulate anti-human leukocyte antigen (HLA) donor-specific antibody (DSA) to facilitate transplantation of sensitized patients, however,…
2019 American Transplant Congress
Vimentin Inhibition Improves Post-Transplant Survival in a Mouse Renal Transplant Model
R. Lopez-Soler¹, Z. Zhang², H. Chin³, J. Wang⁴, K. Ridge⁵
¹Albany Medical College, Albany, NY, ²Microsurgery Core, Comprehensive Transplant Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Molecular and Cellular Physiology, Albany Medical College, Albany, NY, ⁴Microsurgery Core, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Northwestern Univesity, Feinberg School of Medicine, Chicago, IL
*Purpose: Most renal transplants ultimately fail secondary to chronic allograft nephropathy (CAN). The development of Epithelial to Mesenchymal Transition (EMT) in renal tubular epithelial cells…
2019 American Transplant Congress
Kinetics of Pretransplant DSA, Post-Transplant Histology, and Graft Failure after Kidney Transplantation
A. Senev¹, E. Lerut², V. Van Sandt³, J. Callemeyn¹, M. Coemans¹, B. Sprangers², D. Kuypers², M. Emonds¹, M. Naesens²
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²University Hospitals Leuven, Leuven, Belgium, ³Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium
*Purpose: The association between the kinetics of pretransplant DSA levels and outcome after kidney transplantation is currently not well known. In this large cohort study…
2019 American Transplant Congress
Utilizing Changing Patterns of T-cell Metabolism in Aging for Effective Immunosuppression
Y. Nian, T. Heinbokel, K. Minami, R. Maenosono, J. Iske, A. El Khal, S. G. Tullius
Transplant Surgery Research Lab, Brigham and Women’s Hospital, Boston, MA
*Purpose: Metabolic reprogramming has been identified as a critical regulator of immunity. Little is known on changes of T-cell metabolism in aging and how to…