Articles tagged "Graft survival"

2022 American Transplant Congress
CCR2 Antagonism Blocks Microbiota Pro-Inflammatory Effects on Lymph Node Architecture
S. J. Gavzy¹, R. Lakhan², J. Iyyathurai², V. Saxena², Z. L. Lee², B. Ma², E. Mongodin², J. S. Bromberg²
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Maryland, Baltimore, MD
*Purpose: Fecal microbiota transfer (FMT) of Desulfovibrio desulfuricans (Desulfo) triggers a pro-inflammatory immune state, causing decreased laminin α4:α5 ratios in the lymph node (LN), increased…
2022 American Transplant Congress
Five-Year Follow-Up from a Prospective, Randomized Trial of Belatacept-Based, CNI Free/Early Steroid Withdrawal Regimens
H. Hames¹, A. R. Shields¹, E. Yanqui¹, A. Christianson¹, J. Kremer², A. Govil¹, E. S. Woodle¹, R. R. Alloway¹
¹University of Cincinnati, Cincinnati, OH, ²Christ Hospital, Cincinnati, OH
*Purpose: A prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based, calcineurin inhibitor-free (CNI), early corticosteroid withdrawal (ESW) regimens with a tacrolimus (TAC)-based ESW…
2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…
2022 American Transplant Congress
Treg Migration and Suppression Require Engagement with Lymphotoxin Beta Receptor on Lymphatic Endothelial Cells to Protect Islet Allografts
V. Saxena¹, W. Piao¹, L. Li¹, M. WillsonShirkey¹, R. Lakhan¹, S. Walden², K. L. Hippen², B. R. Blazar², J. S. Bromberg¹
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Minnesota, Minneapolis, MN
*Purpose: Treg sequential migration from graft to draining lymph nodes (dLN) via afferent lymphatics is required for Treg suppressive function. Treg lymphotoxin alpha beta (LTαβ)…
2022 American Transplant Congress
Long-Term Clinical Outcomes in ABO Incompatible Kidney Transplantation in Patients with High Baseline Anti-A/B Antibody Titer
S. Eum¹, H. Lee¹, E. Ko¹, H. Yoon², S. Shin², C. Yang¹, B. Chung¹
¹Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine, Incheon St. Mary's Hospital, Incheon, Korea, Republic of
*Purpose: ABO incompatible (ABOi) kidney transplantation (KT) has been considered to overcome donor shortage. We investigated the long-term clinical outcomes in ABOi KT in patients…
2022 American Transplant Congress
High Pretransplant FGF-23 Level is Associated with Poor Graft Survival and Persistent Vitamin D Insufficiency in Kidney Transplant Patients
J. Ryu¹, H. Jeon², T. Koo³, J. Yang⁴
¹Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea, Republic of, ²Department of Internal Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Seongnam Citizens Medical Center, Seongnam, Korea, Republic of, ⁴Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea, Republic of
*Purpose: Vitamin D [25(OH)D] insufficiency and FGF-23 elevation in chronic kidney disease (CKD) is usually ameliorated after kidney transplantation (KT). However, post-transplant vitamin D insufficiency…
2022 American Transplant Congress
Complete and High-Resolution HLA Typing Improves the Accuracy of Post-Transplant Assessment of De Novo Anti-Donor Immune-Mediated Events
M. Meneghini¹, A. Perona², E. Crespo³, F. J. Bemelman⁴, P. M. Reinke⁵, O. Viklicky⁶, M. Giral⁷, O. Bestard¹
¹Vall d'Hebron University Hospital, Barcelona, Spain, ²Universitat de Barcelona, Barcelona, Spain, ³Nephrology and Transplantation Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ⁴Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁵Charité Universitätsmedizin, Berlin, Germany, ⁶Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, ⁷Nantes Université, Inserm, CHU Nantes, Nantes, France
*Purpose: High-resolution (HR) HLA typing using NGS technology has shown to improve the accuracy of assessing donor-recipient compatibility and characterization of pre-transplant anti HLA antibodies…
2022 American Transplant Congress
Kinetic Analysis of Post-Clearance Phase Inflammation in Kidney Biopsies After BK Viremia
M. Vincent¹, J. T. Rajagopal¹, E. Farkash²
¹University of Michigan, Ann Arbor, MI, ²Dept. of Pathology, University of Michigan, Ann Arbor, MI
*Purpose: During the post-clearance phase of BK polyomavirus nephropathy, tubulointerstitial inflammation can persist despite resolution of BK viremia. This inflammation is indistinguishable from low grade…
2022 American Transplant Congress
High Level Cytomegalovirus Viremia in Liver Transplant Recipients: Risk Factors and Associated Outcomes
H. L. Kleiboeker¹, M. R. Jorgenson¹, G. E. Leverson², J. P. Rice³, C. M. Saddler⁴, J. A. Smith⁴, D. Al-Adra³
¹Pharmacy, University of Wisconsin Hospital and Clinics, Madison, WI, ²Department of Surgery, UW School of Medicine and Public Health, Madison, WI, ³Department of Medicine, Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁴Department of Medicine, Division of Infectious Diseases, University of Wisconsin School of Medicine and Public Health, Madison, WI
*Purpose: To evaluate epidemiology, risk-factors and outcomes of high-level CMV viremia in LTX recipients.*Methods: Retrospective review of adults who received LTX between 1/1/2017-9/30/2020. Inclusion criteria…
2022 American Transplant Congress
Validation of the iBox Surrogate End Point in CNI Free, Belatacept Treated Patients (BENEFIT & BENEFIT-EXT)
G. Divard¹, O. Aubert¹, M. Raynaud¹, F. Vincenti², L. Rostaing³, A. Durbach⁴, C. Legendre¹, R. Vadanici⁵, A. Loupy¹, -. BENEFIT & BENEFIT-EXT Investigators⁶
¹Paris Transplant Group, INSERM, Paris, France, ²UCSF, San Francisco, CA, ³Grenoble, Grenoble, France, ⁴APHP, Paris, France, ⁵BMS, Rueil Malmaison, France, ⁶BMS, New York, NY
*Purpose: The iBox is a prognostication system for long-term kidney allograft survival, developed with mostly patients under a CNI based immunosuppression. Patients treated with a…