2022 American Transplant Congress
Impact of Donor Quality on Outcomes for AKI and Non-AKI Kidneys with and without DGF
*Purpose: The relevance of DGF, and whether it is clinically significant, continues to be debated. Our aim was to compare post-transplant outcomes between AKI and…2022 American Transplant Congress
Experience Using Intra-Operative Dialysis in Surgically Complex Liver Transplantation
1Anesthesiology, Ochsner, New Orleans, LA, 2Surgery, Ochsner, New Orleans, LA
*Purpose: At our high-volume center, we often perform liver transplantation (LT) on surgically complex patients that includes re-transplantation, prior open liver resection, bariatric surgeries, extensive…2022 American Transplant Congress
Role of Urinary Biomarkers in RWE Clinical Paradigm
1Nephrosant, Brisbane, CA, 2NephroSant, Brisbane, CA
*Purpose: Due to heterogeneity observed in the kidney transplant population, it has been extremely challenging for traditional methods such as histopathology to predict graft outcomes.…2022 American Transplant Congress
Il-33 Induced Regulatory Macrophages Inhibit Transplantation Immune Rejection by Inducing Tregs
Beijing Chaoyang Hospital, Beijing, China
*Purpose: The occurrence of acute and chronic rejections after transplantation are key factors that affect the survival of the recipients. Induction of transplantation immune tolerance…2022 American Transplant Congress
Prospective Study of Preimplantation Biopsy in Deceased Donor Kidney Transplantation (DDKT)
*Purpose: Our aim was to study the impact of preimplantation biopsy (Bx) findings in selecting kidneys from more marginal donors.*Methods: This is a 2-year prospective…2022 American Transplant Congress
Successful Use of Anti-IL-6R Therapy to Achieve Cardiac Allograft Tolerance in Non-Human Primates
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: In contrast to kidney allografts, attempts to achieve tolerance of isolated cardiac allografts in non-human primates (NHPs) using a mixed chimerism strategy have been…2022 American Transplant Congress
Treg Migration and Suppression Require Engagement with Lymphotoxin Beta Receptor on Lymphatic Endothelial Cells to Protect Islet Allografts
1University of Maryland School of Medicine, Baltimore, MD, 2University of Minnesota, Minneapolis, MN
*Purpose: Treg sequential migration from graft to draining lymph nodes (dLN) via afferent lymphatics is required for Treg suppressive function. Treg lymphotoxin alpha beta (LTαβ)…2022 American Transplant Congress
Histologic Predictors of Graft Loss in Early Clinically Indicated Biopsies After Kidney Transplantation
*Purpose: We aimed to investigate histopathological predictors of graft lost in patients who underwent clinically indicated biopsies for worsening kidney function and/or proteinuria within 3…2022 American Transplant Congress
Autophagy is an Important Factor in the Development of Fibrosis Following Renal Injury; Implications for Post-Transplant IFTA
*Purpose: Interstitial Fibrosis and Tubular Atrophy (IFTA) is the most common cause of long-term graft failure following renal transplant. There is currently no effective therapy.…2022 American Transplant Congress
Dendritic Cell Senescence as a Key Contributor to Transplant Rejection
1Brigham and Women’s Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD
*Purpose: Intra-graft inflammation initiated by ischemia-reperfusion injury (IRI) is an unavoidable consequence of transplantation surgery and constitutes a key source of alloimmune responses. IRI leads…
American Transplant Congress abstracts