ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft survival"

  • 2022 American Transplant Congress

    Living Donor Kidney Transplant in Recipients with Glomerulonephritis: Donor Recipient Biologic Relationship and Allograft Outcomes

    R. El-Rifai1, R. Spong1, A. Bregman1, K. Swanson1, S. Jackson2, S. Riad1

    1Nephrology, University of Minnesota, Minneapolis, MN, 2MHealth, Minneapolis, MN

    *Purpose: Controversies exist over the impact of donor-recipient biologic relationship on the outcomes of living donor kidney transplant in recipients with glomerulonephritis (GN). The improved…
  • 2022 American Transplant Congress

    Clinical Significance of the Living Kidney Donor Profile Index in Living Kidney Donors for Predicting of Post-Transplant Outcome: Korean Organ Transplantation Registry

    J. Kim1, D. Kim1, S. Yoon1, S. Kang1, J. Kim1, H. Hwang1, K. Jeong1, H. Ko2, C. Jung3, D. Kim4, Y. Kim5, J. Yang6, C. Ahn7

    1Department of Nephrology, Kyung Hee University hospital, Seoul, Korea, Republic of, 2Department of Surgery, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, 3Department of Transplantation and Vascular Surgery, Korea University Anam Hospital, Seoul, Korea, Republic of, 4Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Korea, Republic of, 5Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea, Republic of, 6Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, 7Department of Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of

    *Purpose: According to recent reports, a risk index for living donor kidney transplantation (LDKT) such as the Kidney donor profile index (KDPI), a non-invasive method…
  • 2022 American Transplant Congress

    Fibroblastic Reticular Cell Lama4 Regulates T Cell Migration to Lymph Nodes and Adaptive Immunity

    L. Li1, M. Shirkey1, T. Zhang1, W. Piao1, V. Saxena1, Z. Mei1, Y. Guo1, A. Krupnick1, A. Kensiski1, S. Gavzy1, R. Abdi2, J. Bromberg1

    1Surgery, UMB, Baltimore, MD, 2Harvard University, Boston, MA

    *Purpose: Lymph node (LN) stromal laminin α4 (Lama4) is associated with tolerance. We hypothesized that fibroblastic reticular cell (FRC) derived Lama4 contributes to a tolerogenic…
  • 2022 American Transplant Congress

    Depletion of Donor Macrophages Permits Post-Transplant Tolerance Induction

    M. Dilts1, A. Dangi2, X. Luo3

    1Pathology, Duke University, Durham, NC, 2Medicine, Duke University, Durham, NC, 3Duke University School of Medicine, Durham, NC

    *Purpose: Using donor splenocytes fixed with cross-linker ethylcarbodiimide (ECDI-SPs), our lab has induced tolerance in a variety of murine and non-human primate models when one…
  • 2022 American Transplant Congress

    Recurrence of Membranous Nephropathy After Kidney Transplantation – TANGO Consortium

    F. Hullekes1, A. Uffing1, L. Riella1, P. Cravedi2

    1Harvard Medical School, Boston, MA, 2Mount Sinai, New York, NY

    *Purpose: Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Several breakthroughs in recent decades, including the identification of anti-PLA2R Abs, aided…
  • 2022 American Transplant Congress

    Elevated Donor-Derived Cell-Free DNA (dd-cfDNA) in the Early Post-Transplant Period is Associated with an Increased Incidence of Adverse Clinical Outcomes in Kidney Transplant Recipients

    D. Wojciechowski1, A. Patel2, S. Anand3, J. Klein4, A. Paramesh5, P. Sood6, G. Shekhtman7, N. Agrawal7, M. Fei7, K. Qu7, D. C. Brennan8

    1University of Texas, Southwestern, Dallas, TX, 2Saint Barnabas Medical Center, Livingston, NJ, 3Intermountain Healthcare, Murray, UT, 4University of Kansas Medical Center, Kansas City, KS, 5Tulane University School of Medicine, New Orleans, LA, 6University of Pittsburgh Medical Center, Pittsburgh, PA, 7CareDx, Brisbane, CA, 8Johns Hopkins School of Medicine, Baltimore, MD

    *Purpose: Early post-transplant elevations in dd-cfDNA, even in the absence of histologic rejection or other overt pathology, have been suggested to carry a risk of…
  • 2022 American Transplant Congress

    Cold Ischemia Time is More Critical for Older Donor Kidney Survival: A Machine Learning Approach

    J. Kim, J. Ahn, A. Massie, D. Segev, S. Bae

    Johns Hopkins, Baltimore, MD

    *Purpose: Increasing utilization of kidneys from older donors is a potential solution to mitigate the organ shortage. However, older donor age is a risk factor…
  • 2022 American Transplant Congress

    Utility of Urinary CTGF as a Biomarker of Progressive Allograft Dysfunction in Pediatric Renal Transplant Recipients

    L. Sheward1, J. Wedel1, N. Rodig1, A. Kho1, T. Blydt-Hansen2, R. B. Mannon3, D. M. Briscoe1

    1Boston Children's Hospital, Boston, MA, 2BC Children's Hospital, Vancouver, BC, Canada, 3University of Nebraska Medical Center, Omaha, NE

    *Purpose: Previous reports from a number of studies indicate that renal allograft recipients who have inflammatory infiltrates within areas of interstitial fibrosis with tubular atrophy…
  • 2022 American Transplant Congress

    Recipient MCPggaac Haplotype is Associated with Poor Graft Survival in Recipients with De Novo Thrombotic Microangiopathy

    V. Petr1, D. Csuka2, P. Hruba3, Á. Szilágyi2, Z. Prohászka2, O. Viklicky1

    1Dept. of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, 2Dept. of Medicine and Hematology, Semmelweis University, Budapest, Hungary, 3Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

    *Purpose: De novo thrombotic microangiopathy (TMA) is associated with poor kidney graft survival. We aimed to assess the role of common complement haplotypes in kidney…
  • 2022 American Transplant Congress

    Study Of Matrix Metalloproteinases(MMP) And Tissue Inhibitors Of Metalloproteinases(TIMP) In Renal Transplant Recipients(RTR)- Rejectors Versus Stable Graft

    J. P. Tom1, R. Dhital2, A. Sharma3, R. Aggarwal1, R. Nada4, R. Ramachandran5, S. Anand1, M. Minz6, R. Minz1

    1Department of Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 2Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, 3Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 4Department of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 5Department of Nephrology, Post Graduate Institute of Medical Education and Research, Chandigarh, India, 6Department of Renal Transplant Surgery, Fortis Hospital, Mohali, Mohali, India

    *Purpose: Our study aimed to shed light on the role of serum levels of MMP and their inhibitors- TIMP in renal allograft rejection.*Methods: This was…
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