Articles tagged "Graft survival"

2015 American Transplant Congress
Intermittent High Dose Intravenous Immunoglobulin as Treatment for Donor Specific Antibodies in Renal Transplant Recipients
P. Bolin,¹ K. Parker,² F. Rana,¹ W. Bryant,¹ P. Jawa,¹ R. Harland.³
¹Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; ²Vidant Medical Center, Greenville, NC; ³Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC.
Background: Donor-specific HLA antibody (DSA) formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population have indicated…
2015 American Transplant Congress
No Significant Outcome Benefit for Brand-Name Versus Generic Tacrolimus in Kidney Transplant Recipients: SRTR Analysis
D. Goldfarb,¹ E. Poggio,¹ S. Flechner,¹ R. Fatica,¹ J. Schold.²
¹Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH; ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH.
IntroGeneric formulations of tacrolimus have been available for maintenance immunosuppression since 2009. Our aim was to evaluate the frequency of use of generic tacrolimus and…
2015 American Transplant Congress
Induction Therapy Improves 15-Year Graft Survival in Kidney Transplant Recipients With Acute Rejection
R. Bajoka, M. Goggins, A. Patel.
Transplant Institute, Henry Ford Hospital, Detroit, MI.
Background: Graft(GS) and patient survival(PS) has been shown to be superior in patients without delayed graft function (DGF) or acute rejection(AR). Induction therapy(IT) is frequently…
2015 American Transplant Congress
Intra-Allograft Common Rejection Module (CRM) Expression in Kidney Transplants Diagnoses Acute Rejection and Predicts Long Term Graft Prognosis
Y. Ng, S. Roedder, O. Bestard, T. Sigdel, S.-C. Hsieh, M. Sarwal.
Surgery, UC San Francisco, San Francisco, CA.
Background: Previous studies with cross-organ transcriptional analysis of 794 allograft biopsies from kidney, liver, heart and lung transplant patients identified a common rejection module (CRM)…
2015 American Transplant Congress
Impact of HLA Antibody Monitoring After Kidney Transplantation
S. Rao,¹ M. Ghanta,¹ H. Parekh,² A. Gillespie,¹ I. Lee,¹ S. Geier,² K. Lau,³ S. Karhadkar,³ A. Di Carlo,³ S. Constantinescu.¹
¹Nephrology, Temple Univesity School of Medicine, Philadelphia, PA; ²Pathology, Temple Univesity School of Medicine, Philadelphia, PA; ³Surgery, Temple Univesity School of Medicine, Philadelphia, PA.
The impact of donor specific antibodies (DSA) and optimal therapeutic intervention for DSA in kidney transplant (KT) recipients has been reported with variable results. We…
2015 American Transplant Congress
Integrated Clinical-Histological (ICH) Score System for the Evaluation of “Marginal” Donors in Kidney Transplantation
M. Fiorentino,¹ M. Rossini,¹ P. Gallo,¹ G. Castellano,¹ A. Schena,¹ G. Grandaliano,² P. Ditonno,³ M. Bataglia,³ L. Gesualdo.¹
¹Department of Emergency and Organ Transplantation, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy; ²Department of Medical and Surgical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Foggia, Italy; ³Department of Emergency and Organ Transplantation, Andrology, Urology and Renal Transplantation Unit, University of Bari, Bari, Italy.
INTRODUCTION: The organ shortage has led to increase the procurement of kidney from “marginal” donors and to improve the strategies to better evaluate the quality…
2015 American Transplant Congress
A Critical Analysis of the Impact of Socioeconomic Status on Racial Disparities in Kidney Transplantation
D. Taber, M. Gebregziabher, M. Hamedi, T. Srinivas, K. Chavin, P. Baliga, L. Egede.
Medical University of South Carolina, Charleston, SC.
Socioeconomic status (SES) is a significant determinant of health outcomes and may be an important component of racial disparities in kidney transplantation (KTX). While the…
2015 American Transplant Congress
Management of Pancreas Graft Splenic Vein Thrombosis: Is Conservative Management Safe?
J. Harbell,¹ T. Morgan,² V. Feldstein,² G. Roll,¹ A. Posselt,¹ S.-M. Kang,¹ S. Feng,¹ R. Hirose,¹ C. Freise,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Radiology, University of California, San Francisco, San Francisco, CA.
Background: Prophylaxis for graft portal/splenic venous thrombosis following pancreas transplant varies between institutions. Similarly, treatment of venous thrombosis ranges from early re-exploration to conservative management…
2015 American Transplant Congress
Angiopoietin-2 Associates With Graft Failure and Mortality in Renal Transplant Recipients
W. Westendorp,¹ C. Keyser,² E. van den Berg,² C. Krikke,¹ H. van Goor,³ S. Bakker,² H. Leuvenink.¹
¹Surgery, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ²Nephrology, Groningen Transplant Center, University Medical Center Groningen, Groningen, Netherlands; ³Pathology, University Medical Center Groningen, Groningen, Netherlands.
Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) are involved in stabilizing the vascular endothelium and may play a role in premature mortality and graft failure in renal…
2015 American Transplant Congress
Part II: Rates and Determinants of Progression for De Novo Donor-Specific Antibody Mediated Kidney Allograft Injury
C. Wiebe,^1,2 I. Gibson,³ D. Pochinco,² P. Birk,⁴ T. Blydt-Hansen,⁴ J. Ho,^1,5 M. Karpinski,¹ A. Goldberg,⁴ L. Storsley,¹ D. Rush,¹ P. Nickerson.^1,2,5
¹Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Immunogenetics, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pathology, University of Manitoba, Winnipeg, MB, Canada; ⁴Pediatric and Child Health, University of Manitoba, Winnipeg, MB, Canada; ⁵Immunology, University of Manitoba, Winnipeg, MB, Canada.
The development of de novo donor-specific antibody (dnDSA) is an independent predictor of allograft loss in renal transplantation. Rates and determinants of clinical pathologic progression…