Articles tagged "Graft survival"

2022 American Transplant Congress
Long-Term Outcomes After Conversion to a Belatacept-Based Immunosuppression in Kidney Transplant: A Matched Cohort Study
G. Divard, C. Debiais, C. Legendre, O. Aubert, C. Lefaucheur, A. Loupy
Paris Transplant Group, INSERM, Paris, France
*Purpose: Conversion to belatacept after transplant seems to be safe. However, no studies have reported the long-term efficacy and safety outcomes after conversion to belatacept…
2022 American Transplant Congress
Overexpression of Human Ectonucleoside Triphosphate Diphosphohydrolase 1 (entpd1; Hcd39) Did Not Afford Significant Protection on Porcine Endothelial Cells
R. Matheson¹, B. Gonzalez Nolasco¹, K. Deng¹, R. Garofalo¹, N. Serifis¹, T. M. Coe¹, C. Rhatigan¹, D. Gil¹, D. Cloonan¹, K. Lee¹, K. Hall², M. Youd², J. F. Markmann¹, S. C. Robson³
¹Transplantation surgery research, Massachusetts General Hospital, Boston, MA, ²eGenesis Bio, Cambridge, MA, ³Beth Israel Deaconess Medical Center, Boston, MA
*Purpose: The thromboregulatory and anti-inflammatory potential of human CD39 (hCD39) makes it a gene of interest in xenotransplantation. In porcine endothelium, CD39 activity is generally…
2022 American Transplant Congress
PACAP-Mediated Autophagy Prevents Liver Ischemia Reperfusion Injury in OLT
Z. Xue, B. Yang, R. Busuttil, J. Kupiec-Weglinski, H. Ji
UCLA Medical Center, Los Angeles, CA
*Purpose: Pituitary adenylate cyclase-activating polypeptide (PACAP) is from vasoactive intestinal peptide-glucagon-secretin family. Our group was the first to demonstrate that neuropeptide PACAP, which innervates the…
2022 American Transplant Congress
High KDPI Kidneys: Lifelong Freedom from Dialysis for Elderly Patients
M. M. Romine¹, W. Irish², H. Jones³, A. Aaron², D. Leeser⁴
¹Department of Surgery, Eastern Carolina University, Greenville, NC, ²Eastern Carolina University, Greenville, NC, ³Eastern Nephrology Associates, Greenville, NC, ⁴East Carolina University, Greenville, NC
*Purpose: According to national data, there is an increase in kidney transplants in patients over 65, corresponding to an overall general increase. Elderly patients continue…
2022 American Transplant Congress
PSGL-1-mTOR-TIM3 Signaling in a Murine Model of Hindlimb Transplantation
K. Kadono¹, F. Messner², J. He², Y. Guo², B. Oh², G. Brandacher², J. Kupiec-Weglinski¹
¹UCLA Medical Center, Los Angeles, CA, ²Johns Hopkins UJohns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Peri-transplant tissue damage driven by innate-adaptive immune cascades resulting from ischemia-reperfusion injury (IRI) is a major concern in vascularized composite allotransplantation (VCA). Here, we…
2022 American Transplant Congress
Does Donor-to-Recipient Weight Mismatch Influence Short Term Outcomes of Deceased Donor Kidney Transplantation?
L. Sabbagh, M. Killackey, H. Jeon, K. Atiemo, A. Paramesh, A. Vijay
Tulane University School of Medicine, New Orleans, LA
*Purpose: The functional nephron mass of an allograft is often taken into consideration when contemplating transplanting a small kidney into a large recipient. We aim…
2022 American Transplant Congress
Tocilizumab in Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients: A Case Series
B. Boonpheng¹, R. Bakthavatsalam², C. D. Blosser¹, I. C. De Castro¹, I. Gimferrer³, Y. Ng¹, N. Leca¹
¹Nephrology, University of Washington, Seattle, WA, ²Surgery, University of Washington, Seattle, WA, ³Bloodworks Northwest, Seattle, WA
*Purpose: The optimal treatment for chronic active antibody-mediated rejection (ca-AMR) remains unclear. Tocilizumab (TCZ), a monoclonal antibody against IL-6, has been proposed in ca-AMR treatment…
2022 American Transplant Congress
Influence of Converting Kidney Transplant Recipients with High Tacrolimus Variability to the Once Daily LCP Tac Formulation
D. Taber, F. Bartlett, N. Patel, T. Sprague, S. Patel, J. Newman, E. Andrade, N. Rao, A. Posadas, V. Rao, M. Casey, D. Dubay, V. Rohan
Med Univ of South Carolina, Charleston, SC
*Purpose: Tacrolimus (Tac) is the cornerstone of immunosuppression used in kidney transplant recipients (KTRs). Tac high variability, low time in therapeutic range and non-adherence are…
2022 American Transplant Congress
Vitrification of Pancreatic Islets and Transplantation
J. S. Rao¹, L. Zhan¹, D. Tobolt¹, M. Q. Slama², N. Sethia¹, Z. Han¹, C. S. Dutcher¹, Q. Peterson², J. C. Bischof¹, E. B. Finger¹
¹University of Minnesota, Minneapolis, MN, ²Mayo Clinic, Rochester, MN
*Purpose: A limitation to potential cure for diabetes through islet transplantation is insufficient islet equivalence (IEQ) from a single donor to achieve insulin independence in…
2022 American Transplant Congress
Final Flow and Resistance During Cold Pulsatile Perfusion Preservation Do Have Value in Prediction of Deceased Donor Graft Survival After Adjusting for KDPI
D. S. Keith, E. Lessmann
Kidney Transplant, Sacred Heart Hospital, Pensacola, FL
*Purpose: To determine whether cold pulsatile perfusion preservation (CPPP) parameters of flow and resistance provide additional data regarding deceased donor kidney graft survival after adjusting…