ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft survival"

  • 2015 American Transplant Congress

    miRNA-181 Promotes Graft Prolongation by Plasmacytoid Dendritic Cells By Increasing T Regulatory Cells and Decreasing B Cells as Revealed By Cytometry By Time-Of-Flight

    A. Lau,1,2 M. Vitalone,1 X. Qu,1 T. Shawler,1 O. Martinez,1 C. Esquivel,1 S. Krams.1

    1Surgery, Stanford University, Stanford, CA; 2Pediatrics, UCSF, San Francisco, CA.

    Liver allografts are well tolerated and other solid organ allografts, when transplanted concurrently with livers, show improved outcomes. However, the mechanisms underlying “hepatic tolerance” have…
  • 2015 American Transplant Congress

    Serum Creatinine Is Most Predictive of Graft Loss in Late Antibody Mediated Rejection

    G. Agarwal, D. Diskin, R. Reed, J. Locke, V. Kumar.

    Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.

    Development of acute antibody mediated rejection (AMR) is associated with graft loss and can occur both early (< 3 months) and late (> 3 months)…
  • 2015 American Transplant Congress

    A Preliminary Study of Using Small Intestinal Submucosa Scaffolds Coated Islets and Mesenchymal Stem Cells to Built Artificial Pancreas

    D. Wang, X. Ding, W. Xue, J. Zheng, X. Feng, X. Tian, Y. Li.

    Department of Renal Transplant, Center of Nephropathy, The First Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

    Background: Although islet transplantation successful applied, shortage of donors, poor islet survival and toxicity of immunosuppressants often reduce the graft functional lifetime. Tissue engineered scaffold…
  • 2015 American Transplant Congress

    Immunological Evaluation of Acellular Extracellular Matrix Upon Transplantation

    M. Ketaki,1 P. Pradeep,1 N. Nikhil,1 G. Dellgren,3 H. Suchitra, M. Olausson.2

    1Laboratory for Transplantation Regenerative Medicine, Surgery, Gothenburg University, Gothenburg, Sweden; 2Department of Surgery, SU/Sahlgrenska University Hospital, SE 41345, Gothenburg, Sweden; 3Cardiothoracic Surgery, Transplant Institute, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg, Sweden.

    Background : To mitigate the scanty supply of donor organs, porcine tissues can be utilized since, it embrace the potential to accomplish the task of…
  • 2015 American Transplant Congress

    The Impact of Center Volume on Simultaneous Kidney-Pancreas Transplantation Outcomes

    A. Malone,1 D. Brennan,1 J. Wellen,2 T. Alhamad.1

    1Transplantation Nephrology, Renal Division, Washington University, St Louis; 2Section of Transplant Surgery, Washington University, St Louis.

    Background: Pancreas transplantation is associated with a high incidence of surgical complications and successful outcomes require experienced surgical and post-transplant care. Prior studies have linked…
  • 2015 American Transplant Congress

    Intermittent High Dose Intravenous Immunoglobulin as Treatment for Donor Specific Antibodies in Renal Transplant Recipients

    P. Bolin,1 K. Parker,2 F. Rana,1 W. Bryant,1 P. Jawa,1 R. Harland.3

    1Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 2Vidant Medical Center, Greenville, NC; 3Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC.

    Background: Donor-specific HLA antibody (DSA) formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population have indicated…
  • 2015 American Transplant Congress

    ABO-Incompatible Live Donor Kidney Transplants Inferior to ABO-Compatible Transplants, but Match Deceased Donor Results: Is Kidney Paired Donation the Answer?

    J. Verbesey, M. Cooper, A. Gilbert, M. Grafals, P. Weems, J. Moore, S. Ghasemian, C. Nilubol, B. Javaid.

    Georgetown University School of Medicine, MedStar Georgetown Transplant Institute, Kidney and Pancreas Transplant Program, Washington, DC.

    Objective: Compare kidney allograft survival in ABO-incompatible (ABO-I) and ABO-compatible (ABO-C) live donor kidney transplant recipients.Methods: We analyzed UNOS database for patients who underwent a…
  • 2015 American Transplant Congress

    Role of Innate Immune Cells in Chronic Allograft Loss and Novel Strategies to Target Them

    C. Wu,1,2 P. Zhao,1 W. Liu,1 X. Xiao,1 X. Shi,1 Y. Peng,1 M. Kloc,1 X. He,2 M. Ghobrial,1 X. Li.1

    1Center for Immunobiology and Transplantation Research, Houston Methodist Hospital and Houston Methodist Research Institute, Houston, TX; 2Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.

    Despite remarkable improvements in short term transplant survival, the long-term outcome of allografts remains poor in the clinic, and most transplants are eventually lost due…
  • 2015 American Transplant Congress

    Kidney Plasmacytoid Dendritic Cells Display Distinct Cell Surface Markers and May Explain the Induction of Tolerance by Kidney Allografts

    N. Oh, M. Tonsho, D. Ndishabandi, R. Colvin, J. Madsen, A. Alessandrini.

    Massachusetts General Hospital, Boston, MA.

    Achieving tolerance in heart allografts is an important area of research as the need for heart transplantations increase. Recent studies in non-human primates (NHPs) have…
  • 2015 American Transplant Congress

    Retrospective Cohort Study Concerning Efficacy and Safety of Bortezomib in Combination With Or Without Rituximab in Antibody Mediated Rejection in Renal Transplant Recipients

    M. Duerr, N. Lachmann, K. Budde, J. Waiser.

    Charité Universitätsmedizin Berlin, Department of Nephrology, Berlin, Germany.

    Treatment of antibody-mediated rejection (AMR) in renal transplant (tx) patients (pts) is still challenging and long-term outcome remains unsatisfying. Because plasma cells (PCs) are crucial…
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