Articles tagged "Graft survival"

2015 American Transplant Congress
Recreational Marijuana Use Is Not Associated With Worse Kidney Allograft Outcomes
G. Greenan, M. Anders, A. Leeser, J. Bromberg, S. Niederhaus.
Department of Surgery, University of Maryland, Baltimore, MD; Department of Anesthesiology, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD; Department of Surgery, University of Maryland, Baltimore, MD.
Background: As marijuana (MJ) legalization is ongoing, kidney transplant programs need to develop listing criteria for MJ users. No data exist on whether recreational MJ…
2015 American Transplant Congress
The Potential of E-Health to Improve Adherence: Exploring the Patients' View
D. Slaats,¹ M. Tielen,¹ M. Laging,¹ T. van Gelder,² W. Weimar,¹ E. Massey.¹
¹Internal Medicine, Erasmus MC, Rotterdam, Netherlands; ²Internal Medicine and Hospital Pharmacology, Erasmus MC, Rotterdam, Netherlands.
Introduction. Transplant outcomes can be negatively influenced by medication nonadherence. Therefore, there is a need for effective interventions to improve adherence. In recent years due…
2015 American Transplant Congress
Calcineurin-Inhibitor Conversion to mTOR Inhibitor in Renal Transplant Recipients Leads to Worse Long Term Clinical Outcomes
A. Alvarado,¹ A. Shetty,¹ O. Traitanon,¹ J. Leventhal,¹ V. Mas,² D. Chhabra,³ J. Matthews,¹ L. Gallon.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²University of Virgina, Charlottesville, Va; ³Advocate Christ Medical Center, Chicago, IL.
We previously reported the short-term feasibility of Calcineurin-Inhibitor (CNI) elimination in kidney transplant recipients. We now report the long-term clinical impact on renal allograft function…
2015 American Transplant Congress
Rejection Triggers Liver Transplant Tolerance: Involvement of Mesenchyma-Meidated Immune Control Mechanisms
M. Morita, D. Joyce, C. Miller, J. Fung, L. Lu, S. Qian.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Successful organ transplantation relies on lifelong immunosuppression, associated with severe side effects. Induction of tolerance is ideal but elusive in clinic. Indeed spontaneous liver transplant…
2015 American Transplant Congress
Final Results from the BENEFIT-EXT Trial: A 7 Year Follow-Up of Belatacept Treated Patients
S. Florman,¹ J. Medina Pestana,² M. Rial,³ L. Rostaing,⁴ D. Kuypers,⁵ F. Mühlbacher,⁶ M. Polinsky,⁷ U. Meier-Kriesche,⁷ J. Grinyó,⁸ A. Durrbach.⁹
¹Mt Sinai Med Ctr, NY; ²Hosp do Rim e Hipertensão, Sao Paulo, Brazil; ³Inst de Nefrologia, Buenos Aires, Argentina; ⁴Univ Hospital, Toulouse, France; ⁵Univ Hospital Leuven, Leuven, Belgium; ⁶Vienna Transplantation Ctr, Vienna, Austria; ⁷BMS, Lawrenceville; ⁸Univ Hosp Bellvitge, Barcelona, Spain; ⁹Univ Hosp of Bicêtre, Villejuif, France.
Background: At 3 and 5yrs post-transplant, BENEFIT-EXT showed a renal function benefit and consistent safety in belatacept (bela) treated pts vs cyclosporine (CsA). Final 7…
2015 American Transplant Congress
Notch-1 Inhibition Promotes Immune Regulation in Solid Organ Transplantation
C. Magee,¹ M. Ohari,¹ T. Shimizu,¹ S. Ohori,¹ N. Najafian,² L. Riella.¹
¹Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston; ²Cleveland Clinic, Weston.
Notch receptor signaling plays a key role in T cell activation and differentiation, though limited data exist on its importance in immune regulation. Herein, we…
2015 American Transplant Congress
Body Mass Index (BMI) Mismatch in Deceased Kidney Donation Is an Independent Risk Factor for Graft Failure
O. Staeck,¹ D. Khadzhynov,¹ M. Mahn,² K. Budde,¹ F. Fuller,² F. Halleck.¹
¹Nephrology, Charite Universitaetsmedizin, Berlin, Germany; ²Urology, Charite Universitaetsmedizin, Berlin, Germany.
IntroductionThe influence of this BMI-mismatch in deceased kidney donors and their recipients on graft survival is so far not well characterized.MethodsRetrospective long-term observational study of…
2015 American Transplant Congress
Renal Resistance Measured During Pulsatile Perfusion and Long-Term Kidney Transplant Outcomes
S. Sandal, R. Sapir-Pichhadze, M. Cantarovich, S. Paraskevas.
McGill University Health Center, Montreal, QC, Canada.
Background: Pulsatile perfusion (PP) has been shown to reduce the incidence of delayed graft function (DGF) and increase short- and long-term kidney transplant (KT) survival.…
2015 American Transplant Congress
Validation of the Early Postoperative labMELD as Predictor of Outcome After Transplantation of Extended Criteria Donor Livers
D. Hoyer,¹ A. Gallinat,¹ T. Minor,² F. Saner,¹ P. Kocabayoglu,¹ J. Treckmann,¹ A. Paul.¹
¹General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ²Surgical Research Division, University Hospital Bonn, Bonn, Germany.
Background:Since there is no generally accepted standard definition of early allograft dysfunction (EAD) after liver transplantation, we recently suggested postoperative labMELD as predictor for outcome…
2015 American Transplant Congress
Donor CD47 Plays a Critical Role in the Control of Alloreactive T Cell Activation Following Hepatocyte Transplantation
M. Zhang,^1,2 H. Wang,¹ N. Navarro-Alvarez,¹ Y. Zheng,² Y.-G. Yang.¹
¹Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY; ²First Hospital, Jilin University, Changchun, Jilin, China.
Background: The interspecies incompatibility of CD47 is an important mechanism triggering rejection of cellular xenografts, including both hematopoietic and non-hematopoietic cells, by recipient macrophages. Our…