Articles tagged "Graft survival"

2015 American Transplant Congress
Changes in Utilization, Discard, and Outcomes Associated With Hepatitis C (+) Donor Livers in the Era of Direct Acting Anti-Retroviral Therapy
M. Bowring, L. Kucirka, X. Luo, A. Massie, D. Segev, C. Durand.
Johns Hopkins University, Baltimore, MD.
While 45% of liver candidates are hepatitis C (HCV) (+) and might benefit from an HCV (+) donor liver, only 7.1% receive one, and HCV…
2015 American Transplant Congress
Post-Transplant Lymphoproliferative Disorders Following Alemtuzumab Induction in Kidney Transplantation
H. Sawhney, R. Charif, J. Galliford, A. Mclean, D. Taube.
Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, England, United Kingdom.
Post-Transplant Lymphoproliferative Disorder (PLTD) is a well-recognised serious complication in renal transplant recipients. Induction with lymphocyte depleting agents such as thymoglobulin has been associated with…
2015 American Transplant Congress
The Differential Effect of HLA-DQ Mismatching on Renal Allograft Survival in Zero HLA-A,B,DR Mismatched Deceased Donor Transplants
M. Casey,¹ X. Wen,¹ S. Rehman,¹ A. Santos,¹ S. Goldstein,¹ K. Andreoni,¹ B. Kaplan,² K. Womer.¹
¹University of Florida, Gainesville; ²University of Kansas, Kansas City.
The role of HLA-DQ matching in renal graft survival is not well understood and difficult to interpret in the presence of other HLA antigen mismatches.…
2015 American Transplant Congress
The Effect of Compatibility of ABO Blood Type Antigens on Graft Survival of Intestinal Transplants
J. Cai,¹ A. Qing,² G. Wu,³ M. Everly,¹ P. Terasaki.¹
¹Terasaki Foundation Lab, Los Angeles; ²Lincoln High School, Stockton; ³The 4th Military Medical University, Xi-An, China.
Due to the introduction of new immunosuppressive agents and development of pre- and post-transplant patient management, ABO blood group incompatibility is no longer considered an…
2015 American Transplant Congress
Molecular Testing for Microcirculation Injury Enhances the Assessment of Antibody-Mediated Rejection in Human Cardiac Allograft Biopsies
B. Afzali,¹ E. Chapman,¹ B. Adam,¹ F. Riesgo Gil,² D. Kim,² L. Hidalgo,¹ P. Campbell,¹ B. Sis,¹ M. Mengel.¹
¹Dept. of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ²Div. of Cardiology, University of Alberta, Edmonton, AB, Canada.
BACKGROUND: Despite continuous attempts to refine diagnostic consensus, accurate assessment of Antibody-mediated rejection (AMR) is an ongoing unmet need. The microcirculation represents the primary target…
2015 American Transplant Congress
Outcomes of Kidney Transplantation from Hypertensive Living Donors
D.-A. Moutzouris, D. Ellis, K. Koutroutsos, R. Charif, J. Galliford, J. McDermott, D. Taube, M. Loucaidou.
Imperial College Renal and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
The disparity between donor kidney availability and demand has increased utilization of kidneys from marginal living donors, including hypertensive donors. The aim of this study…
2015 American Transplant Congress
Divergence in Risk Factors for Graft Loss and Death Across Race May Mediate Kidney Transplant Outcome Disparity
M. Posadas Salas,¹ D. Taber,² M. Kamel,¹ M. Kadian,¹ M. Salazar,¹ P. Mohan,¹ T. Srinivas.¹
¹Department of Medicine, Medical University of South Carolina, Charleston, SC; ²Department of Surgery, Medical University of South Carolina, Charleston, SC.
Differences in outcomes between African American and non-African American kidney transplant recipients may reflect disparate access to health care. Minimizing this disparity demands a deeper…
2015 American Transplant Congress
Kidney and Liver CIT Variations Across OPOs and Their Implications: US Experience Between 2003 and 2011
J. Melancon, N. Koizumi, C. Callender, D. DasGupta, T. Smith.
Surgery, George Washington University, Washington, DC; Public Policy, George Mason University, Arlington, VA; Surgery, Howard University, Washington, DC; Health Sciences, University of Indianapolis, Indianapolis, IN; School of Engineering, University of Pennsylvania, Philadelphia, PA.
Introduction: Significant variations in kidney and liver transplant outcomes across OPOs have been reported, but their causes remain largely unknown. This study investigated variations in…
2015 American Transplant Congress
Controlling Alloreactive B Cell Responses in Sensitized Recipients With CTLA-4Ig
J. Chen,¹ Q. Wang,¹ D. Yin,¹ V. Vu,¹ R. Sciammas,² A. Chong.¹
¹Depart of Surgery, University of Chicago, Chicago; ²Immunobiology Transplant Center, Houston Methodist Research Institute, Houston.
Sensitized recipients are defined by the presence of pre-transplant donor-specific antibodies and have significantly poorer graft outcomes compared to unsensitized recipients despite efforts to desensitize.…
2015 American Transplant Congress
Reciprocal Relationship Between Cytomegalovirus Infection and Graft Rejection in Intestinal/Multivisceral Transplantation: Impact on Survival and Ideal Immunosuppression Protocol
S. Nagai, R. Mangus, E. Anderson, K. Doan, B. Ekser, C. Kubal, J. Fridell, A. Tector.
Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN.
Background: Cytomegalovius (CMV) infection and graft rejection are opposing complications of isolated intestinal/multivisceral transplantation (IIT/MVT), a procedure requiring precise balance of immunosuppression. The aim of…