Articles tagged "Graft survival"

2015 American Transplant Congress
Donor Hemodynamic Profile Presages Graft Survival in Donation After Cardiac Death Liver Transplantation
M. Ertreo, C. Desai, R. Girlanda, T. Frias, T. Fishbein.
Transplant Institute, Georgetown University Hospital, Washington, DC.
IntroductionDonation after cardiac death (DCD) grafts are prone to periods of prolonged hypoxemia and hypotension prior to donor expiration, leading to an increased complication rate,…
2015 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2)
E. Yin,^1,2 M. Uchiyama,^1,3,4 X. Jin,^1,5 T. Shimokawa,³ H. Yagita,⁴ M. Niimi.¹
¹Department of Surgery, Teikyo University, Tokyo, Japan; ²Department of Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ³Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ⁴Department of Immunology, Juntendo University Hospital, Tokyo, Japan; ⁵Department of Cardiovascular and Thoracic Surgery, The 4th Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…
2015 American Transplant Congress
Risk Factors for Graft Loss in Pediatric Renal Transplant Recipients After Transfer of Care
B. Coyne,^1,2 P. Hollen,^1,2 Y. Guofen,³ K. Brayman.⁴
¹Department of Pediatrics, University of Virginia Health System, Charlottesville, VA; ²School of Nursing, University of Virginia, Charlottesville, VA; ³Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA; ⁴Department of Surgery, University of Virginia Health System, Charlottesville, VA.
Improvements in immunosuppression and transplant surgical technique have increased the survival of children with end-stage renal disease. These patients have complex needs, and the current…
2015 American Transplant Congress
Targeting Complement Pathways During Ischemia and Reperfusion: Implications for the Prevention of Delayed Graft Function
Z. Yu,¹ S. Qi,² M. Lasaro,¹ K. Bouchard,¹ C. Dow,¹ K. Moore,¹ Z. Wu,² A. Barama,² J. Xu,² K. Johnson,¹ A. Marozsan,¹ Y. Wang.¹
¹Pre-Clinical Sciences, Alexion Pharmaceutical Inc., Cheshire, CT; ²Department of Surgery, Hôpital Notre Dame and Université de Montréal, Montréal, QC, Canada.
Complement system plays a critical role in ischemia-reperfusion injury (IRI), and contributes to DGF. The aim of this study was to evaluate the effects of…
2015 American Transplant Congress
Pancreas-Derived Mesenchymal Stem Cells from Chronic Pancreatitis Patients Enhance Islet Graft Function
M. Lawrence,¹ F. Kunnathodi,¹ N. Borenstein-Auerbach,¹ G. Yoshimatsu,¹ M. Kanak,² R. Shahbazov,¹ M. Takita,¹ M. Levy,³ B. Naziruddin.³
¹Baylor Research Institute, Dallas, TX; ²Baylor University, Waco, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
PURPOSE: Islet transplantation represents a promising procedure to reverse or prevent diabetes. However, significant mass of islet graft is lost within hours of transplantation due…
2015 American Transplant Congress
Complement Inhibition Via the Lectin Pathway Improves Experimental Cardiac Graft Survival
J. Kindermann,^1,2 M. Waechter,^1,2 R. Bruno,¹ M. Langenmayer,³ T. Dudler,⁴ W. Schwaeble,⁵ E. Kleinert,¹ T. Mayr,^1,2 H. Christian,² R. Wanke,³ J.-M. Abicht,⁶ S. Guethoff.¹
¹Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany; ²Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; ³Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany; ⁴Omeros Corporation, Seattle, WA; ⁵Department of Infection, Immunity, and Inflammation, Leicester University, Leicester, United Kingdom; ⁶Department of Anaesthesiology, Ludwig-Maximilians University, Munich, Germany.
Purpose: While complement activation via both the classical as well as the lectin pathway is believed to contribute to allograft loss, their relative contribution is…
2015 American Transplant Congress
A Novel Maintenance Regimen With Calcineurin Inhibitor, MMF and Everolimus Initiated By Dual Induction Therapy With Anti-CD20/25 Antibodies in Renal Transplantation
N. Masaki, K. Iwado, I. Nakagima, S. Fuchinoue.
Surgery III, Tokyo Women's Medical University Hospital, Shinjuku-ku,Tokyo, Japan.
【background】Calcineurin inhibitor (CNI), MMF and steroid has been the gold standard of maintenance regimen in renal transplantation (RTx). A line of new immunosuppressants has emerged…
2015 American Transplant Congress
Husband to Wife Renal Transplants Are Associated With a Higher Risk of Early Antibody Mediated Rejection and Transplant Glomerulopathy
H. Sawhney, M. Willicombe, P. Brookes, E. Santos, D. Taube.
Renal and Transplant Centre, Hammersmith Hospital, Imperial Healthcare NHS Trust, London, England, United Kingdom.
Patients with a low level preformed donor specific antibodies [DSA] with a negative FCXM/CDC cross match are at high risk of antibody mediated rejection [AMR]…
2015 American Transplant Congress
Outcomes Following Endovascular Treatment of Hepatic Artery Stenosis Following Liver Transplantation
J. Seal,¹ H. Bohorquez,¹ L. Le,² W. Terral,² A. Cohen,¹ I. Carmody,¹ D. Bruce,¹ T. Reichman,¹ E. Ahmed,¹ W. Sternbergh,² G. Loss.¹
¹Multi-Organ Transplant Institute, Ochsner Health System, New Orleans, LA; ²Department of Surgery, Ochsner Health Systems, New Orleans, LA.
Endovascular treatment of hepatic artery stenosis (HAS) after liver transplantation offers a less invasive alternative to surgical revision or retransplantation. However, outcomes following endovascular treatment…
2015 American Transplant Congress
IFNγ Is Required for nTreg Afferent Lymphatic Migration
S. Ahmad, Y. Xiong, C. Brinkman, J. Bromberg.
Surgery, University of Maryland, Baltimore, MD.
Background: Natural Treg (nTreg) must migrate from graft to draining lymph node (LN) to prolong islet allograft survival, and we previously showed that the transcription…