2015 American Transplant Congress
Human Leukocyte Antigen Mismatch and Steroid Maintenace in Kidney Transplantation
Nephrology and Hypertension, Allegheny General Hospital, Pittsburgh, PA.
Kidney transplant recipients (KTRs) with zero/minimal HLA mismatches against their donors enjoy superior long term outcomes related to diminished immune response of the recipient against…2015 American Transplant Congress
Everolimus and Early Calcineurin Inhibitor Withdrawal Is Associated With Superior Renal Function: 5-Year Follow-Up of the Randomized PROTECT Liver Transplantation Study
PROTECT Study Group, Novartis Pharma GmbH, Germany.
Purpose: At the end of the 12-month (M) PROTECT core study (NCT00378014), de novo liver transplant recipients (LTxR) who switched from a calcineurin inhibitor (CNI)…2015 American Transplant Congress
Thymoglobulin Administration During Multi-Visceral and Isolated Small Bowel Procurement Does Not Adversely Affect the Survival of Harvested Organs
Anti-thymocyte globulin administration in donors before intestinal procurement may result in decreased graft versus-host disease (GVHD) due to reduced recipient lymphocyte trafficking after reperfusion. Reluctance…2015 American Transplant Congress
A Novel Post-Transplant High-Dose Cyclophosphamide-Based Regimen to Promote Immune Tolerance After VCA
Background: VCA has become a viable treatment option for devastating tissue defects. However, the life-long need of immunosuppressive medications curtails the wider use of VCA.…2015 American Transplant Congress
Gene Expression of Kidney Biopsies Reveals Common Mechanisms of Rejection and a Cluster of Co-Expressed Genes Predictive of Long-term Outcomes
1The Scripps Research Institute, La Jolla; 2Northwestern University, Chicago.
Purpose: Acute rejection (AR) still affects 8-14% of kidney transplants and rates of 10-year graft loss remain unchanged in part due to chronic rejection (CR).…2015 American Transplant Congress
Kidneys from Living Donors With High Body Mass Index Do Not Have Inferior Outcomes
Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom.
The disparity between donor kidney availability and demand has increased utilization of kidneys from marginal living donors. Data regarding outcome of transplantation from living donors…2015 American Transplant Congress
Impact of Educational Attainment On Kidney Transplant Outcomes By Race
Educational attainment is associated with disparities in graft and recipient survival in kidney transplant (KTX) candidates; however, the impact of educational status within racial groups…2015 American Transplant Congress
Differential Role of PI3K Subunits Gamma and Delta in Regulatory T Cells Homeostasis in Allotransplantation
Renal/Transplant Research Center, Brigham and Women's Hospital, Boston, MA.
Targeting survival pathways that differentially suppress effector T cells (Teff) while sparing regulatory T cells (Tregs) is key in devising novel tolerogenic protocols in transplantation.…2015 American Transplant Congress
Changes in Utilization, Discard, and Outcomes Associated With Hepatitis C (+) Donor Livers in the Era of Direct Acting Anti-Retroviral Therapy
Johns Hopkins University, Baltimore, MD.
While 45% of liver candidates are hepatitis C (HCV) (+) and might benefit from an HCV (+) donor liver, only 7.1% receive one, and HCV…2015 American Transplant Congress
Post-Transplant Lymphoproliferative Disorders Following Alemtuzumab Induction in Kidney Transplantation
Renal and Transplant Centre, Imperial College Healthcare NHS Trust, London, England, United Kingdom.
Post-Transplant Lymphoproliferative Disorder (PLTD) is a well-recognised serious complication in renal transplant recipients. Induction with lymphocyte depleting agents such as thymoglobulin has been associated with…
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