Articles tagged "Graft survival"

2015 American Transplant Congress
Risk Factors for Graft Loss in Pediatric Renal Transplant Recipients After Transfer of Care
B. Coyne,^1,2 P. Hollen,^1,2 Y. Guofen,³ K. Brayman.⁴
¹Department of Pediatrics, University of Virginia Health System, Charlottesville, VA; ²School of Nursing, University of Virginia, Charlottesville, VA; ³Department of Public Health Sciences, University of Virginia Health System, Charlottesville, VA; ⁴Department of Surgery, University of Virginia Health System, Charlottesville, VA.
Improvements in immunosuppression and transplant surgical technique have increased the survival of children with end-stage renal disease. These patients have complex needs, and the current…
2015 American Transplant Congress
Targeting Complement Pathways During Ischemia and Reperfusion: Implications for the Prevention of Delayed Graft Function
Z. Yu,¹ S. Qi,² M. Lasaro,¹ K. Bouchard,¹ C. Dow,¹ K. Moore,¹ Z. Wu,² A. Barama,² J. Xu,² K. Johnson,¹ A. Marozsan,¹ Y. Wang.¹
¹Pre-Clinical Sciences, Alexion Pharmaceutical Inc., Cheshire, CT; ²Department of Surgery, Hôpital Notre Dame and Université de Montréal, Montréal, QC, Canada.
Complement system plays a critical role in ischemia-reperfusion injury (IRI), and contributes to DGF. The aim of this study was to evaluate the effects of…
2015 American Transplant Congress
Pancreas-Derived Mesenchymal Stem Cells from Chronic Pancreatitis Patients Enhance Islet Graft Function
M. Lawrence,¹ F. Kunnathodi,¹ N. Borenstein-Auerbach,¹ G. Yoshimatsu,¹ M. Kanak,² R. Shahbazov,¹ M. Takita,¹ M. Levy,³ B. Naziruddin.³
¹Baylor Research Institute, Dallas, TX; ²Baylor University, Waco, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
PURPOSE: Islet transplantation represents a promising procedure to reverse or prevent diabetes. However, significant mass of islet graft is lost within hours of transplantation due…
2015 American Transplant Congress
Complement Inhibition Via the Lectin Pathway Improves Experimental Cardiac Graft Survival
J. Kindermann,^1,2 M. Waechter,^1,2 R. Bruno,¹ M. Langenmayer,³ T. Dudler,⁴ W. Schwaeble,⁵ E. Kleinert,¹ T. Mayr,^1,2 H. Christian,² R. Wanke,³ J.-M. Abicht,⁶ S. Guethoff.¹
¹Transregio Collaborative Research Center 127, Ludwig-Maximilians University, Munich, Germany; ²Department of Cardiac Surgery, Ludwig-Maximilians University, Munich, Germany; ³Institute of Veterinary Pathology, Ludwig-Maximilians University, Munich, Germany; ⁴Omeros Corporation, Seattle, WA; ⁵Department of Infection, Immunity, and Inflammation, Leicester University, Leicester, United Kingdom; ⁶Department of Anaesthesiology, Ludwig-Maximilians University, Munich, Germany.
Purpose: While complement activation via both the classical as well as the lectin pathway is believed to contribute to allograft loss, their relative contribution is…
2015 American Transplant Congress
A Novel Maintenance Regimen With Calcineurin Inhibitor, MMF and Everolimus Initiated By Dual Induction Therapy With Anti-CD20/25 Antibodies in Renal Transplantation
N. Masaki, K. Iwado, I. Nakagima, S. Fuchinoue.
Surgery III, Tokyo Women's Medical University Hospital, Shinjuku-ku,Tokyo, Japan.
【background】Calcineurin inhibitor (CNI), MMF and steroid has been the gold standard of maintenance regimen in renal transplantation (RTx). A line of new immunosuppressants has emerged…
2015 American Transplant Congress
Husband to Wife Renal Transplants Are Associated With a Higher Risk of Early Antibody Mediated Rejection and Transplant Glomerulopathy
H. Sawhney, M. Willicombe, P. Brookes, E. Santos, D. Taube.
Renal and Transplant Centre, Hammersmith Hospital, Imperial Healthcare NHS Trust, London, England, United Kingdom.
Patients with a low level preformed donor specific antibodies [DSA] with a negative FCXM/CDC cross match are at high risk of antibody mediated rejection [AMR]…
2015 American Transplant Congress
Outcomes Following Endovascular Treatment of Hepatic Artery Stenosis Following Liver Transplantation
J. Seal,¹ H. Bohorquez,¹ L. Le,² W. Terral,² A. Cohen,¹ I. Carmody,¹ D. Bruce,¹ T. Reichman,¹ E. Ahmed,¹ W. Sternbergh,² G. Loss.¹
¹Multi-Organ Transplant Institute, Ochsner Health System, New Orleans, LA; ²Department of Surgery, Ochsner Health Systems, New Orleans, LA.
Endovascular treatment of hepatic artery stenosis (HAS) after liver transplantation offers a less invasive alternative to surgical revision or retransplantation. However, outcomes following endovascular treatment…
2015 American Transplant Congress
IFNγ Is Required for nTreg Afferent Lymphatic Migration
S. Ahmad, Y. Xiong, C. Brinkman, J. Bromberg.
Surgery, University of Maryland, Baltimore, MD.
Background: Natural Treg (nTreg) must migrate from graft to draining lymph node (LN) to prolong islet allograft survival, and we previously showed that the transcription…
2015 American Transplant Congress
Is There a Difference in Patient and Graft Survival in Children Weighing <20 kg Versus Those Weighing >20 kg at the Time of Renal Transplantation?
P. Chandak,¹ J. Stojanovic,² R. Sivaprakasam,³ N. Mamode,¹ F. Calder,¹ J. Olsburgh,¹ M. Drage,¹ C. Callaghan,¹ J. Taylor,¹ G. Koffman,¹ J. Taylor,² S. Marks,⁴ N. Kessaris.¹
¹Transplant Surgery, Guys and St Thomas Hospitals NHS Trust, London, United Kingdom; ²Nephrology, Evelina Childrens Hospital, London, United Kingdom; ³Transplant Surgery, Royal London Hospital, London, United Kingdom; ⁴Department of Nephrology and Transplantation, Great Ormond Street Hospital for Children, London, United Kingdom.
Introduction: Renal transplantation (RTx) is the gold standard treatment modality for end-stage kidney disease. There are increased challenges in pediatric renal transplant recipients (pRTR) under…
2015 American Transplant Congress
Etiology, Incidence and Outcomes of the Highly Sensitized Kidney Transplant Patient
R. Redfield, T. Zens, J. Scalea, M. Rizzari, D. Mandelbrot, D. Kaufman, A. Djamali.
University of Wisconsin, Madison, WI.
Background: Sensitization to HLA antigens is a major barrier to kidney transplantation. We sought to determine the etiology, incidence and outcomes of kidney transplants performed…