Articles tagged "Graft survival"

2015 American Transplant Congress
Portal Flow <1000 cc Is Not Associated With Early Graft Dysfunction in Orthotopic Liver Transplantation
M. Gastaca,¹ M. Prieto,¹ A. Matarranz,¹ A. Valdivieso,¹ P. Ruiz,¹ A. Ventoso,¹ I. Palomares,¹ L. Martinez-Indart,² J. Fernandez,³ J. Ortiz de Urbina.¹
¹Hepatobiliary Surgery and Liver Transplantation Unit, Cruces University Hospital. University of the Basque Country, Bilbao, Vizcaya, Spain; ²Epidemiology Unit, Cruces University Hospital. University of the Basque Country, Bilbao, Vizcaya, Spain; ³Hepatology Unit, Cruces University Hospital. University of the Basque Country, Bilbao, Vizcaya, Spain.
Purpose: The aim of our study was to determine whether a portal flow <1000 cc after orthotopic liver transplantation (OLT) is associated with a higher…
2015 American Transplant Congress
Inhibition of T Cell Metabolism Reveals a New Approach to Preventing Graft Rejection
C.-F. Lee,^1,2 Y.-C. Lo,² G. Furtmüller,³ B. Oh,³ V. Andrade-Oliveira,² A. Thomas,⁴ G. Brandacher,³ J. Powell.²
¹Department of Liver and Transplantation Surgery, Chang-Gung Memorial Hospital-Linkou Branch, Taoyuan, Taiwan; ²Sidney-Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD; ³Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; ⁴Brain Science Institute, Neurotranslational Program Johns Hopkins University School of Medicine, Baltimore, ND.
Upon antigen recognition and co-stimulation, T cells up-regulate the metabolic machinery necessary to proliferate and sustain effector function. Hallmarks of this response include a switch…
2015 American Transplant Congress
The Impact of Duration of Brain Death on Outcomes in Abdominal Organ Transplantation: Rush and Retrieve or Rather Relax and Repair?
C. Boffa,¹ E. Curnow,² K. Martin,² R. Johnson,² R. Ploeg.¹
¹Nuffield Department of Surgical Sciences, Oxford, United Kingdom; ²NHS Blood and Transplant, Bristol, United Kingdom.
Background: Brain death (BD) induces a progressive systemic pro-inflammatory and coagulatory response affecting function of the grafts-to-be and survival. With longer BD duration more injury…
2015 American Transplant Congress
Outpatient Management of Delayed Graft Function (DGF) Is Associated With Reduced Length of Stay and Acute Rejection
B. Muth,¹ B. Astor,¹ J. Turk,¹ M. Mohamed,¹ S. Parajuli,¹ D. Kaufman,² D. Mandelbrot,¹ A. Djamali.^1,2
¹Department of Medicine, University of Wisconsin, Madison, WI; ²Department of Surgery, University of Wisconsin, Madison, WI.
Delayed graft function (DGF) increases hospital length of stay (LOS) and risk for readmission, rejection, early graft loss and death. We created a multidisciplinary DGF…
2015 American Transplant Congress
Improved Long-Term Graft Survival in Renal Transplant Recipients With Donor Specific Antibodies (DSA) After Mycophenolic Acid Escalation
L. Rebellato,¹ K. Parker,² F. Rana,³ S. Kendrick,⁴ C. Morgan,⁵ C. Haisch,⁵ M. Everly,⁶ R. Harland,⁵ P. Bolin.³
¹Pathology and Laboratory Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; ²Vidant Medical Center, Greenville, NC; ³Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; ⁴Eastern Nephrology Associates, Greenville, NC; ⁵Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC; ⁶Terasaki Foundation, Los Angeles, CA.
Background: DSA formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population indicate DSA formation is a…
2015 American Transplant Congress
The Outcomes of Second Transplantation in Recurrent IgA Nephropathy
C. Baek,¹ H. Kim,¹ W. Yang,¹ W. Huh,² Y. Kim,³ J. Yang,⁴ D. Han,⁵ S.-K. Park.¹
¹Department of Internal Medicine, Asan Medical Center, Seoul, Republic of Korea; ²Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; ³Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; ⁴Transplantation Center, Seoul National University Hospital, Seoul, Republic of Korea; ⁵Department of Surgery, Asan Medical Center, Seoul, Republic of Korea.
BackgroundRecurrence of original glomerulonephritis is an important cause of graft loss. In some studies, histologic recurrence of IgA nephropathy (IgAN) occurs in 60% after 1st…
2015 American Transplant Congress
Single Infusion of Donor-Type Splenocytes Treated With Extracorporeal Photopheresis Prior to Transplantation Significantly Prolongs Cardiac Allograft Survival in Mice
J. Schneiderman,¹ J. Ye,² X. Yeap,² M. Caralt,² J.-J. Wang,² Z. Zhang.²
¹Ped Hematology/Oncology/Stem Cell Transplant, Feinberg School of Medicine Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Background: Extracorporeal Photopheresis (ECP) is an immune therapy in which blood leukocytes are treated with 8-methoxypsoralen (8-MOP), exposed to UV-A light, and re-infused. This study…
2015 American Transplant Congress
Kidney Transplant Outcomes in Recipients Older Than 70: A Single Center Experience
M. Yaqub, A. Sharfuddin, M. Mujtaba, D. Mishler, T. Taber, W. Goggins, N. Kassis Akl.
Indiana University Health, Indianapolis, IN.
Age is no longer considered a contraindication to renal transplantation. To date, little is known in regards to the grafts and patients outcomes in elderly…
2015 American Transplant Congress
ABO-Incompatible Liver Transplantation for Severe Hepatitis B Patients
J. Zhou, W. Ju, X. Yuan, X. Jiao, D. Wang, X. Zhu, X. He.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Objectives: Effect of ABO-incompatible liver transplantation on severe hepatitis B (SHB) patients is still unclear. Herein, we described 22 successful cases of patients with SHB…
2015 American Transplant Congress
Liver-Specific Transcription Factor ATF5 Participates in Regulation of IFN-γ/B7-H1 Signaling Pathway in Liver Mesenchymal Cells
G.-Q. Shen, L. Wang, J. Fung, L. Lu, S. Qian.
Immunology, Lerner Research Institute; 2General Surgery, Digestive Disease Insttute, Cleveland Clinic, Cleveland, OH.
Liver transplant tolerance was initially discovered in pigs, rats and mice. A recent paper reviewed ∼400 liver transplant patients worldwide who had undergone weaning of…