Articles tagged "Graft survival"

2016 American Transplant Congress
Cold Ischemia Induced Outcomes in Kidney Transplantation: A Meta-Analysis.
D. Bennett, M. Mustafa, M. Chiles, W. Skillen, S. Mohan.
Columbia University Medical Center, New York, NY.
Objective: To examine the association between cold ischemia time (CIT) and delayed graft function (DGF) and death-censored graft failure in kidney transplantation.Methods: To identify relevant…
2016 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2).
E. Yin,^1,2 M. Uchiyama,^1,3 X. Jin,^1,4 T. Shimokawa,³ H. Yagita,⁵ M. Niimi.¹
¹Surgery, Teikyo University, Tokyo, Japan; ²Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ³Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ⁴Thoracic Surgery, The 3rd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Immunology, Juntendo University Hospital, Tokyo, Japan.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…
2016 American Transplant Congress
Pediatric En Bloc Kidney Transplants Reduce DGF and Are Misrepresented by the KDPI.
M. Khan,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
Controversy exists regarding optimal use of kidneys from small pediatric donors (SPDs). The study purpose was to compare outcomes between single and dual en bloc…
2016 American Transplant Congress
Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.
I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4
¹Microbiology and Immunology, Western University Canada, London, ON, Canada; ²Pathology, Western University Canada, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴Surgery, Western University Canada, London, ON, Canada.
Organ procurement is inherently associated with ischemia-reperfusion injury (IRI), resulting from loss and subsequent restoration of blood flow, which is detrimental to short- and long-term…
2016 American Transplant Congress
Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact.
E. Montanari,¹ R. Meier,² D. Bosco,¹ R. Mahou,³ P. Morel,² J. Seebach,⁴ C. Wandrey,³ C. Gonelle-Gispert,¹ L. Bühler.²
¹University of Geneva, Geneva, Switzerland; ²Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ³Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ⁴Division of Immunology and Allergy, University Hospitals of Geneva, Geneva, Switzerland.
Background: MSC exhibit immunomodulatory and anti-inflammatory properties. Notably, MSC were shown to preserve human islet function and to prevent cytokine-induced apoptosis. Aim: To evaluate the…
2016 American Transplant Congress
Outcomes of Isolated Pediatric Small Intestine Transplants Using Vascular Homografts.
Y. Kwon, N. Llore, R. Girlanda, K. Etesami, C. Desai, C. Matsumoto, T. Fishbein.
MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC.
Background/aim: Pediatric intestinal transplantation has changed recently with more isolated small intestine transplants being performed in small children instead of combined liver-intestine transplants. Consequently, surgical…
2016 American Transplant Congress
Have We Gone Too Far Defining Performance Outliers? One-Third of Kidney Transplant Programs Now Identified for Low Performance within Three Years.
J. Schold,¹ C. Miller,¹ M. Henry,² L. Buccini,¹ S. Flechner,¹ D. Goldfarb,¹ E. Poggio,¹ K. Andreonni.³
¹Cleveland Clinic, Cleveland, OH; ²Ohio State University, Columbus, OH; ³University of Florida, Gainesville, FL.
Transplant center report cards developed by SRTR are publicly available and utilized for regulatory oversight and insurance contracting. There are significant associations of performance oversight…
2015 American Transplant Congress
Etiology, Incidence and Outcomes of the Highly Sensitized Kidney Transplant Patient
R. Redfield, T. Zens, J. Scalea, M. Rizzari, D. Mandelbrot, D. Kaufman, A. Djamali.
University of Wisconsin, Madison, WI.
Background: Sensitization to HLA antigens is a major barrier to kidney transplantation. We sought to determine the etiology, incidence and outcomes of kidney transplants performed…
2015 American Transplant Congress
Mesenchymal Stem Cells Enhance Rejection Free and Overall Islet Allograft Survival
N. Kenyon,¹ M. Willman,¹ H. Dongmei,¹ H. Ana,¹ A. Rabassa,¹ W. Diaz,¹ J. Geary,¹ N. Kenyon,¹ A. Bartholomew,² K. McHenry,³ D. Salomon,⁴ D. Berman.¹
¹Surgery, University of Miami School of Medicine, Miami, FL; ²Surgery, University of Illinois at Chicago, Chicago, IL; ³National Center for Supercomputing and Analysis, University of Illinois at Urbana-Champaign, Urbana-Champaign, IL; ⁴Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA.
The purpose of this study was 1) to assess the effect of mesenchymal stem cells (MSC) on intrahepatic, allogeneic islet survival in a cynomolgus monkey…
2015 American Transplant Congress
Correlates of Clinical Course of Polyomavirus BK Infection With Long-Term Outcome of BK Virus-Associated Nephropathy in Renal Transplant Patients
G. Huang, C.-X. Wang, J.-G. Fei, J. Qiu, S.-X. Deng, J. Li, G.-D. Chen, Q. Fu, R.-H. Deng, L.-Z. Chen.
Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Background: Identification of risk factors for the long-term outcome of BK virus (BKV) -associated nephropathy(BKVAN) may improve renal transplant outcome. Methods: Between 2006 and 2014,…