Articles tagged "Graft survival"

2022 American Transplant Congress
Pegylated Lacritin N-104 Promotes Mouse Islet Stabilization and Prevents Diabetes Progression in the Non-Obese Diabetic (NOD) Mouse Model
M. Ma¹, P. Chhabra¹, G. Laurie², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Cell Biology, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if PEGylated Lacritin N-104 (PEG N-104) prevents the progression of type 1 diabetes (T1D) in the NOD mouse.*Background: Lacritin is a multifunctional…
2022 American Transplant Congress
Novel Biopsy-Based Clinical Phenotype Clustering to Predict Kidney Transplant Outcomes
A. Ahmed¹, L. Allegretti², C. Rebello³, B. Kinsella³, K. Guo³, S. Park⁴, J. Friedewald³
¹Chicago Medical School at Rosalind Franklin University, Chicago, IL, ²University of Wisconsin, Madison, WI, ³Northwestern University, Chicago, IL, ⁴Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: The purpose of this study was to define novel clinical phenotypes based on biopsy results to enhance biomarker discovery.*Methods: Retrospective analysis of kidney biopsy…
2022 American Transplant Congress
Life Supporting Orthotopic Cardiac Xenotransplantation Using Multiple Human Gene Expressing Pigs in Non Human Primates
A. K. Singh¹, C. Goerlich¹, T. Zhang¹, I. Tatarov¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, B. Lewis¹, A. Hershfeld¹, F. Sentz¹, D. Ayares², D. Kaczorowski¹, B. Griffith¹, M. Mohiuddin¹
¹Department of Surgery, University of Maryland, Baltimore, MD, ²Revivicor Inc, Blacksburg, WV
*Purpose: Cardiac xenotransplantation (CXTx) is proposed as an alternate treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically engineered (GE) pig…
2022 American Transplant Congress
The Effect of Late-Onset Cytomegalovirus Infection on the Outcome of Renal Allograft in Patients with Delayed Graft Function
M. Rahimi Shahmirzadi¹, M. Silverman¹, L. Gunaratnam², A. Jevnikar², A. A. House², S. Hosseini-Moghaddam³
¹Infectious Diseases Care Program, St. Joseph's Health Care London, London, ON, Canada, ²London Health Sciences Centre, London, ON, Canada, ³St. Joseph's Health Care London, London, ON, Canada
*Purpose: Delayed graft function (DGF) has been reported to increase the risk of renal allograft loss. The role of late-onset Cytomegalovirus infection in the association…
2022 American Transplant Congress
The Effect of Bariatric Surgery Pre-Transplant on Renal Transplant Outcomes
R. Zaminpeyma, S. Negi, N. Saberi, A. Andalib, S. Paraskevas, J. Tchervenkov
Surgery, McGill, Montreal, QC, Canada
*Purpose: We compared post-transplant outcomes in patients with morbid obesity undergoing pre-transplant bariatric surgery to non-obese and obese patients without bariatric surgery.*Methods: Adult recipients of…
2022 American Transplant Congress
Performance of Donor Derived Cell Free DNA (dd-cfDNA) in Diagnosing Subclinical and Clinical Acute Rejection in Kidney Transplant Recipients
T. Cober, P. West-Thielke, C. Miller, N. Grund, M. Altrich, A. Sutton, R. Sinha, M. Miller, S. Kleiboeker, J. Weems
Eurofins, Framingham, MA
*Purpose: The aim of this study was to examine the performance of Viracor TRAC donor derived cell free DNA (dd-cfDNA) in for-cause biopsies as well…
2022 American Transplant Congress
External Validation of the Abbreviated Ibox Scoring System at One-Year Post Kidney Transplant as a Surrogate Endpoint for Death-Censored Graft Survival
A. Klein¹, L. Kosinski², R. Muse², A. Loupy³, O. Aubert³, G. Divard³, M. Stegall⁴, I. Helanterä⁵, W. E. Fitzsimmons¹, I. O'Doherty¹
¹Transplant Therapeutics Consortium, Critical Path Institute, Tucson, AZ, ²Critical Path Institute, Tucson, AZ, ³Paris Transplant Group, Paris, France, ⁴Mayo Clinic, Rochester, MN, ⁵Helsinki University Hospital, Helsinki, Finland
*Purpose: The Transplant Therapeutics Consortium seeks to translate the iBox from Loupy et al., 2019 into a surrogate endpoint for five-year death-censored graft survival after…
2022 American Transplant Congress
Ficoll-Based Isolation Alters the Immunogenicity of Islets That Leads to Enhanced Rejection in Allogeneic Hosts
L. Zhang¹, A. Turan², M. Tarique¹, V. Ulker¹, E. Yolcu³, H. Shirwan³
¹Child Health, University of Missouri, Columbia, MO, ²Molecular Microbiology and Immunology, University of Missouri, Columbia, MO, ³Child Health and Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO
*Purpose: The purification of pancreatic islets has long relied on the time-consuming density gradient separation method. We herein report a filtration method as an efficient,…
2022 American Transplant Congress
Impact of Cold Ischemia Times on 1 Year Kidney Transplant Outcomes
T. Fletchinger, L. Burdine
Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: Recent organ allocation changes have increased travel and subsequent cold ischemia times (CIT) of kidney allografts. We sought to investigate the impact of prolonged…
2022 American Transplant Congress
Impact of Delayed Graft Function in Donation After Circulatory Death Kidney Transplantation
J. Mello Offerni¹, H. Brar¹, D. Lee¹, M. Levine², M. Mandurah¹, S. Rim¹, A. Sener¹, P. Luke¹
¹Urology, Western University, London, ON, Canada, ²Division of Urology, Department of Surgery, University of Alberta, Edmonton, AB, Canada
*Purpose: Donation after circulatory death (DCD) has been associated with higher rates of delayed graft function (DGF) when compared to donation after brain death (DBD).…

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