2021 American Transplant Congress
Multiplexed Imaging Mass Cytometry of the Alloimmune Landscape of Rejection in Clinical Liver Transplantation
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Imaging Mass Cytometry (IMC) is an emerging preclinical technique…2021 American Transplant Congress
Dna-pkcs Regulation of the Allogeneic Immune Response
University of Arkansas, Little Rock, AR
*Purpose: Organ transplantation is life-saving and continued investigations into immunological mechanisms that drive organ rejection are needed to improve immunosuppression therapies and prevent graft failure.…2021 American Transplant Congress
Sequential Analysis of Renal Allograft Rejection at Single Cell Resolution
*Purpose: Renal allograft anti-rejection therapies (corticosteroids (CCS) and anti-lymphocyte globulin) have been the primary treatment modalities for over six decades, yet little is known about…2021 American Transplant Congress
The Efficacy of Delayed Fc-nonbinding Anti-CD3 Antibody Treatment in Sensitized Allogeneic Mouse Heart Transplantation
*Purpose: Delayed treatment with Fc-nonbinding anti-CD3 antibody (ab) permits early graft infiltrating cells to promotes a transplant tolerance. However, graft infiltrating cells immediate after transplantation…2021 American Transplant Congress
Neutrophil CEACAM1 Induces Hepatic Autophagy and Shapes Innate-adaptive Immune Response in Liver Transplantation: From Mouse-to-human
1Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, 2Surgery, Kyoto University, Kyoto, Japan
*Purpose: Although CEACAM1 (CC1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates innate-adaptive immunity, its role in orthotopic liver transplantation (OLT) remains unknown. CC1 expresses…2021 American Transplant Congress
Dynamic Reconstitution of Recipient Resident Memory T Cell Repertoire After Human Intestinal Transplantation
Columbia University, New York, NY
*Purpose: Our studies in intestinal transplant (ITx) recipients demonstrated that donor T cell blood macrochimerism(peak level ≥4%) is associated with slower graft T cell replacement…2020 American Transplant Congress
Steroid Withdrawal and Lymphocyte Subsets in Graft Capillary Blood versus Peripheral Blood in Low Immunological Risk Kidney Transplant Patients: Randomized, Parallel Group, Controlled Clinical Trial
Regional University Hospital, Malaga, Spain
*Purpose: Whether steroid withdrawal can modulate the subclinical inflammatory response after a kidney transplant is unknown.*Methods: We undertook a controlled multicenter clinical trial involving 105…2020 American Transplant Congress
Multiplexed Imaging Mass Cytometry Analysis Reveals a New Role for CD68+ Macrophages in Chronic Liver Transplant Rejection
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Recently, a novel high-resolution mass spectrometry-based technique has been…2020 American Transplant Congress
Novel Approaches in Targeting Chromatin Modifiers in the Induction of Transplant Tolerance
Houston Methodist Research Institute, Houston, TX
*Purpose: Bromodomain and extra-terminal domain (BET) proteins are a family of proteins that function as epigenetic readers that regulate transcriptional activities of target genes. BET…2019 American Transplant Congress
The Impact of Biological Behavior of Allograft Infiltrating Lymphocytes during Early Phase
Gastroenterological Surgery I, Hokkaido University, Sapporo, Japan
*Purpose: The graft infiltrating lymphocytes (GILs) build an immunological microenvironment locally. Reportedly the GILs within 72hrs posttransplantation do not attack allograft, but may prevent from…
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