Articles tagged "Graft function"

2015 American Transplant Congress
Clinical and Pathologic Predictors of Response to Belatacept Conversion
S. Patel, H. Morris, D. Cohen, S. Mohan, L. Ratner, R. Crew.
Columbia Universtiy, New York.
INTRO: Calcineurin inhibitors have improved kidney transplant and recipient survival, their use has significant nephrotoxicity. Belatacept is a recently approved immunosuppressant that is not nephrotoxic…
2015 American Transplant Congress
Transversal Observational Study On Recurrent and Late Urinary Tract Infections (UTIs) in Renal Transplantation (tx)
G. Castellano,¹ M. Fiorentino,¹ M. Martino,¹ M. Rossini,¹ A. Schena,¹ C. Manno,¹ G. Grandaliano,² P. Ditonno,³ M. Battaglia,³ L. Gesualdo.¹
¹DETO, Nephrology, Dialysis and Transplantation Unit, University of Bari, Bari, Italy; ²Department of Medical and Surgical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Foggia, Italy; ³DETO, Andrology, Urology and Renal Transplantation Unit, University of Bari, Bari, Italy.
UTIs are common complications after kidney tx. The aim of this study was to define the potential predisposing factors and the possible impact on graf…
2015 American Transplant Congress
Mitochondrial Feedback Mechanisms in Kidney Cell Senescence
K. De Vusser,¹ K. Hochstenbach,² E. Winckelmans,² E. Lerut,³ D. Kuypers,¹ T. Nawrot,² M. Naesens.¹
¹Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Centre for Environmental Sciences, Hasselt University, Hasselt, Belgium; ³Department of Pathology, University Hospitals Leuven, Leuven, Belgium.
BackgroundProgressive DNA damage (telomere attrition) is considered one of the key instigators of ageing. Different models for ageing where DNA damage leads to accelerated senescence…
2015 American Transplant Congress
In House Oxygen Persufflation of Cold Stored Livers Versus Simple Cold Storage in Extended Criteria Liver Grafts: Results of a Randomized Controlled Clinical Trial
A. Gallinat,¹ A. Paul,¹ D. Hoyer,¹ C. Klein,¹ S. Swoboda,¹ C. Ose,² Z. Mathe,¹ J. Treckmann,¹ T. Minor.³
¹Dept. of General-, Viszeral- und Transplantation Surgery, University Hospital Essen, Essen, Germany; ²Institute of Computer Science in Medicine, Biostatistics and Epidemiology, University Hospital Essen, Essen, Germany; ³Surgical Research Div., Universiy Clinic Surgery, Bonn, Germany.
Two hours of end-ischemic oxygen persufflation of cold stored porcine livers regenerates cellular energy dependent pathways and improves survival after transplantation. The present trial evaluated…
2015 American Transplant Congress
Delayed Tacrolimus (TAC) to Rapamycin (RAPA) Conversion in Renal Transplant Recipients With DGF/SGF
A. Haririan,¹ D. Klassen,¹ M. Keshtkar,¹ C. Drachenberg,² T. Dowling,³ E. Ramos,¹ R. Ugarte,¹ C. Cangro,¹ M. Weir.¹
¹Medicine, University of Maryland, Baltimore, MD; ²Pathology, University of Maryland, Baltimore, MD; ³Pharmacy, University of Maryland, Baltimore, MD.
The role of conversion from TAC to RAPA early after kidney transplantation in patients with DGF/SGF in improving graft function and delaying chronic allograft dysfunction…
2015 American Transplant Congress
Rat Forelimb Allotransplantation: A Novel Microsurgical Model for Optimized Functional Assessment After Reconstructive Transplantation
B. Kern,¹ S. Tuffaha,¹ M. Khusheim,¹ S. Xiang,¹ G. Furtmueller,¹ K. Sarhane,¹ J. Park,² A. Hoke,² W. Lee,¹ G. Brandacher.¹
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore, MD; ²Neurology and NeuroSurgery, Johns Hopkins University, Baltimore, MD.
Background:Functional outcomes following vascularized composite allotransplantation (VCA) have been promising, but there is still room for improvement. Studies to investigate strategies to overcome this obstacle…
2015 American Transplant Congress
Impact of Early Urinary Tract Infections on Renal Graft Function
J. Rago, L. Bowman, D. Brennan, J. Hagopain, T. Horwedel.
Barnes Jewish Hospital, St Louis, MO.
Purpose: Describe the incidence of early urinary tract infections (UTI) after renal transplantation at a large academic transplant center. Evaluate the impact of early UTIs…
2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ E. Sitarek,¹ A. Sadowska,¹ M. Nowaczyk,⁵ T. Grochowiecki,⁶ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland; ⁶General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…
2015 American Transplant Congress
Impact of Donor Post-Extubation O2 Delivery on Recipient Hypoxic Cholangiopathy in Donation After Circulatory Death Liver Transplantation: The University of Colorado Experience
T. Chirichella,¹ C. Dunham,² M. Zimmerman,⁴ K. Conzen,¹ S. Kelley,³ E. Phelan,¹ T. Steinberg,¹ T. Nydam,¹ T. Bak,¹ I. Kam,¹ M. Wachs.¹
¹Transplant Surgery, University of Colorado Hospital, Aurora, CO; ²Department of Surgery, St. Elizabeth Health Center, Youngstown, OH; ³Donor Alliance Organ Procurement Organization, Denver, CO; ⁴Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI.
The critical shortage of deceased organ donors has led to increased utilization of DCD liver grafts. The purpose of this study was to evaluate DCD…
2015 American Transplant Congress
Prognostic Relevance of Rejection Episodes Detected Within the First 3 Weeks After Kidney Transplantation
V. Arelin,¹ H. Schrem,² F. Lehner,² W. Gwinner,¹ H. Haller,¹ M. Schiffer.¹
¹Division of Nephrology and Hypertension, Department of Medicine, Hannover Medical School, Hannover, Lower Saxony, Germany; ²General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Lower Saxony, Germany.
Background:The relevance of cellular rejection events detected in the early phase after kidney transplantation for graft survival and function remains to be elucidated. Especially the…