Articles tagged "Graft function"

2022 American Transplant Congress
Intraoperative Kinetics of Pro-Inflammatory Markers and Delayed-Graft Function During Kidney Transplantation
P. A. Wadsworth, H. L. Stevenson, M. L. Kueht
University of Texas Medical Branch, Galveston, TX
*Purpose: Detailed molecular changes associated with allograft reperfusion have been poorly defined and current methods of predicting delayed graft function (DGF) after kidney transplantation are…
2022 American Transplant Congress
Acute Tubular Injury and Necrosis Do Not Lead to Meaningful Elevations in Donor-Derived Cell-Free DNA (dd-cfDNA)
S. R. Allam¹, M. Cooper², D. Kumar³, T. Maw⁴, A. Wiseman⁵, P. Chuang⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, E. Huang⁸
¹Medical City Transplant Institute, Fort Worth, TX, ²Medstar Georgetown Transplant Institute, Washington, DC, ³Virginia Commonwealth University, Richmond, VA, ⁴University of Southern California, Los Angeles, CA, ⁵Centura Health, Denver, CO, ⁶Metrolina Nephrology, Charlotte, NC, ⁷CareDx, Brisbane, CA, ⁸Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Associations between non-rejection histologic diagnoses and dd-cfDNA have not been extensively characterized. We explored these associations in kidney transplant recipients enrolled in the Kidney…
2022 American Transplant Congress
Timing of Hypotension Post Kidney Transplant Impacts the Risk of Subsequent Delayed Graft Function
S. A. Morrison¹, A. Thanamayooran², K. Tennankore¹, A. J. Vinson¹
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Hypotension is common post-kidney transplant and is associated with delayed graft function (DGF; a need for dialysis in the first week post-transplant) and prolonged…
2022 American Transplant Congress
The Correlation Between Kidney Donor Risk Index, Kidney Graft Function and Histological Changes in Early Post-Transplant Renal Biopsy
N. Slabiak-Blaz, A. Kujawa-Szewieczek, A. Kolonko, H. Karkoszka, A. Wiecek, G. Piecha
Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland
*Purpose: An appropriate assessment of donor organ quality is crucial to optimize the kidney allocation and improve the long-term outcomes. Kidney Donor Risk Index (KDRI),…
2022 American Transplant Congress
Prebiotic Supplementation In Kidney Transplant Recipients For Preventing Infections And Gastrointestinal Upset: A Randomized Controlled Feasibility Study
S. Chan¹, C. M. Hawley¹, E. M. Pascoe², C. Z. Cao², S. B. Campbell², K. L. Campbell³, R. S. Francis², R. Hale¹, N. M. Isbel⁴, M. Morrison⁵, D. W. Johnson²
¹Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia, ²Princess Alexandra Hospital, Woolloongabba, Australia, ³Menzies Health Institute - Molecular Basis of Disease Research Program, Griffith University, Brisbane, Australia, ⁴Princess Alexandra Hospital, Brisbane, Australia, ⁵Diamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Australia
*Purpose: Modulating the large intestinal microbiome of kidney transplant recipients (KTR) may reduce infectious complications. The aim of this study was to assess the feasibility…
2022 American Transplant Congress
Kidney Grafts with Poor 24-Month Function Present Upregulated Immune Activity at Pre-Transplantation
E. Bardhi¹, K. Archer², D. Maluf¹, J. McDaniels¹, T. Rousselle¹, E. Akalin³, T. Mueller⁴, V. Mas¹
¹University of Maryland, Baltimore, MD, ²Ohio State University, Columbus, OH, ³Montefiore Medical Center, Bronx, NY, ⁴University Hospital Zürich, Zürich, Switzerland
*Purpose: A transcriptomic profile serves as a snapshot of the temporary cell state and thus, analyzing pretransplant kidney biopsies can provide detailed information on the…
2022 American Transplant Congress
Improvement in Kidney Function After Early Conversion to Belatacept-Based Regimen in Allografts with Biopsy-Proven Donor Vascular Disease
T. Ommert¹, J. Javier¹, J. Jackson¹, C. Klein²
¹Piedmont Transplant Institute, Piedmont Atlanta Hospital, Atlanta, GA, ²Piedmont Transplant Institute, Atlanta, GA
*Purpose: Donor arteriosclerosis in the kidney allograft predicts poorer graft outcomes and is a risk factor for tacrolimus-induced nephrotoxicity. Belatacept conversion has been utilized as…
2022 American Transplant Congress
Normal Saline vs Electrolyte-a Use Peri- and Post-Operatively in Adult Kidney Transplant Recipients
K. R. Szempruch, A. D. Martschenko, H. Arora, R. Isaak, R. Prasad, P. Serrano
UNC Medical Center, Chapel Hill, NC
*Purpose: 0.9% normal saline (NS) has been used as the standard fluid replacement in kidney transplant recipients (KTRs) to prevent dehydration and to improve renal…
2022 American Transplant Congress
Defining the Characteristics and Graft Outcomes of Kidney Transplant Recipients with Pre-Transplant Elevated Plasma Oxalate Levels
D. Khan, N. Zhang, M. Keddis
Mayo Clinic, Scottsdale, AZ
*Purpose: The objective of this study is to compare graft outcomes for patients with pre-transplant elevated plasma oxalate (Pox) compared to a matched cohort.*Methods: Kidney…
2022 American Transplant Congress
A Sign of Things to Come? Clinical Markers After Elevated Donor-Derived Cell-Free DNA in Heart Transplant Recipients
D. T. Kim¹, E. J. Henricksen², B. M. Zhang³, J. J. Teuteberg¹, Y. Moayedi⁴, H. I. Luikart¹, J. Han⁵, B. Wayda¹, K. Khush¹
¹Cardiology, Stanford University, Stanford, CA, ²Transplant, Stanford Health Care, Stanford, CA, ³Pathology, Stanford University, Stanford, CA, ⁴Cardiology, University Health Network, Toronto, ON, Canada, ⁵Cardiology, University of Chicago, Chicago, IL
*Purpose: Endomyocardial biopsy (EMBx) has historically been the standard of care for surveillance post heart transplant (HTx), but is limited by sample area and interpretation.…

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