2016 American Transplant Congress
Understanding the Drivers Behind an Early Post-KAS Rise in Delayed Graft Function (DGF) Rates.
Background: DGF among solitary deceased donor kidney transplants (tx) increased by 22% (p<0.0001) -- from 24.6% to 30.1% -- during the first 6 months of…2016 American Transplant Congress
Implications of Subclinical Borderline Acute Cellular Rejection Detected in Protocol Biopsies on Graft Outcomes.
Background: The effects of subclinical borderline acute cellular rejection (BACR-defined as I1T1 per Banff criteria) detected in protocol biopsies (Bx) on subsequent graft function and…2016 American Transplant Congress
A 30% Decrease in Post-kidney Transplant Estimated Glomerular Filtration Rate (eGFR) from 6 Mo-2 Y Is a Surrogate for 5 Y eGFR: Results from Clinical Trials in Organ Transplantation-(CTOT)-17.
Predicting long-term kidney allograft outcomes using early clinical/biomarker data could guide individualized therapy. Emerging evidence in progressive native kidney disease indicates >30% decrease in eGFR…2016 American Transplant Congress
The Significance of Microvascular Inflammation in Antibody-Mediated Rejection in ABO-Incompatible Kidney Transplantation.
Background: In ABO-incompatible (ABOi) transplantation, the criteria for antibody-mediated rejection (AMR) are controversial, as C4d deposition is common in ABOi. This study examined the impact…2016 American Transplant Congress
Risk Stratification for Optimized Utilization of Deceased Donor Kidneys with Acute Kidney Injury by KDIGO Criteria.
BackgroundDeceased donor kidneys with acute kidney injury (AKI) raise fear of poor graft outcomes to the transplant clinicians and consequently are often discarded. However, the…2016 American Transplant Congress
The First Impressions: A Study in Pre and Post-Implantation Renal Grafts for Early Detection Markers of Delayed Graft Function and Recovery.
1UVA, Charlottesville; 2VCU, Charlottesville; 3Northwestern University, Chicago.
Background: Delayed graft function (DGF) is mainly a consequence of ischemia and reperfusion injury (IRI) resulting in acute tubular necrosis. The degree of IRI is…2016 American Transplant Congress
Pre-Transplant Panel of Reactive T Cells (PRT) as an Independent Predictor of 2-Year Kidney Graft Function.
Background: The ELISPOT PRT quantifies frequencies of IFN-g-producing effector/memory T cells reactive against a panel of allogenic stimulators. In contrast to the donor-reactive ELISPOT, it…2016 American Transplant Congress
Impaired Outcome of Kidney Transplants from Donors with Acute Kidney Injury.
Given the gap between patients in need of a kidney transplantation and organs available, transplantation centers increasingly accept lower quality organs, e.g. from donors with…2016 American Transplant Congress
Prognosis Value of the Presence and Persistence of C1q Binding Anti-HLA Antibodies in Acute Antibody-Mediated Rejection in Kidney Transplantation.
Purpose : Longitudinal study of C1q complement fraction binding capacity of donor specific anti-HLA antibodies (DSAs) as a pronostic marker in acute antibody-mediated rejection.Methods :…2016 American Transplant Congress
Imminent Death Donation: Potential Effects on Organ Donation Numbers and Clinical Outcomes.
Attempts at donation after cardiac death (DCD) lead to organ transplantation only among 70% of eligible DCDs. Imminent death donation (IDD) is ante-mortem donation of…
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