Articles tagged "Graft function"

2017 American Transplant Congress
Everolimus Does Not Increase Risk of Delayed Graft Function or Prolong Duration of Dialysis in Renal Transplantation.
F. Shihab,¹ Y. Qazi,² S. Mulgaonkar,³ K. McCague,⁴ D. Patel,⁴ V. Peddi,⁵ D. Shaffer.⁶
¹Univ of Utah, Salt Lake City; ²Univ of Southern California, Los Angeles; ³Barnabas Health, West Orange; ⁴Novartis, East Hanover; ⁵California Pacific Medical Center, San Francisco; ⁶Vanderbilt Univ Medical Center, Nashville
US92 (NCT01025817) is a phase III, 12 month, open-label, randomized study comparing everolimus (EVR) plus low-dose tacrolimus (LTac) vs. mycophenolate mofetil (MMF) with standard-dose tacrolimus…
2017 American Transplant Congress
Macrophage Specific Deletion of RhoA Inhibits Fractalkine Signaling and Abrogates Chronic Rejection of Cardiac Allograft.
M. Kloc, Y. Liu, W. Chen, X. Li, R. Ghobrial.
Surgery, Houston Methodist Hospital and Research Institute, Houston
Objective. Chronic rejection of transplanted organs remains unresolved issue in organ transplantation. The chronic rejection is the most common cause of graft loss within 10…
2017 American Transplant Congress
Correlation of Donor Clinical and Histopathological Characteristics with Graft Function in Kidney Transplant Recipients.
M. Zachariah,¹ C. Yip,¹ M. Zachariah, I. Mallawaarachchi,² A. Dweivedi,² S. Patel,⁴ A. Gundroo,¹ J. Tomaszewski,¹ L. Lin,¹ C. Shirley.¹
¹Medicine, SUNY at Buffalo, Buffalo, NY; ²Biostatistics and Epidemiology, Texas Tech University, El Paso, TX; ³Pathology, SUNY at Buffalo, Buffalo, NY; ⁴Surgery, SUNY at Buffalo, Buffalo, NY
Background: There is lack of consensus in the perceived accuracy of frozen biopsy interpretation. Interobserver variability in assessment of pre-implantation biopsies limits its value to…
2017 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Improves Function of Extreme Marginal Renal Grafts Subjected to Prolonged Ischemia.
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ C. Cassol,² R. John,² P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,³ D. Grant,¹ L. Robinson,⁴ M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ²Laboratory Medicine and Pathobiology, Toronto General Hospital, University Health Network, Toronto, ON, Canada; ³Departments of Surgery (Urology) and Physiology, The Hospital for Sick Children, Toronto, ON, Canada; ⁴Division of Nephrology, The Hospital for Sick Children, Toronto, ON, Canada
Background: Normothermic ex-vivo kidney perfusion (NEVKP) is an emerging technique for renal graft preservation. We investigated whether NEVKP could promote improved marginal graft function compared…
2017 American Transplant Congress
Kidney Re-Transplantation (KRTx) from Donation After Cardiocirculatory Death (DCD)-Standard Criteria Donors (SCD).
M. Khan, B. Alradawna, A. Farney, J. Rogers, G. Orlando, A. Reeves-Daniel, A. Palanisamy, M. Gautreaux, W. Doares, S. Kaczmorsky, R. Stratta.
Transplant, Wake Forest Baptist Medical Center, Winston Salem, NC
Donation after cardiac death (DCD) donor kidneys increase the organ pool but use in kidney retransplantation (KRTx) has been questioned due to higher rates of…
2017 American Transplant Congress
Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated with Belatacept.
W. Kitchens, A. Farris, S. Pastan, T. Pearson, C. Larsen, A. Adams.
Emory Transplant Center, Atlanta, GA
Introduction: Focal segmental glomerulosclerosis (FSGS) is a cause of end-stage renal failure that frequently recurs following renal transplant, often leading to allograft loss. A recently…
2017 American Transplant Congress
Technical Refinement to Prevent Hepatic Outflow Disturbance in Right Lobe Living Donor Liver Transplantation: Simplified One-Orifice Venoplasty.
J. Kim, D. Choi.
Department of Surgery, Catholic University of Daegu College of Medicine, Daegu, Republic of Korea
Middle hepatic vein (MHV) reconstruction is often essential to avoid hepatic congestion and serious graft dysfunction in living donor liver transplantation (LDLT). The aim of…
2017 American Transplant Congress
Clusterin Levels at 3-Months Associate with DGF and 12-Month Fibrosis – Reinforcing the Early Injury to Fibrosis Continuum.
M. Menon,¹ L. Liriano-Ward,² N. Philippe,¹ C. Wei,¹ W. Zhang,¹ Z. Yi,¹ K. Keung,² P. O'Connell,² B. Murphy.¹
¹Medicine, Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Medicine, Westmead Millenium Institute, Sydney, NSW, Australia
The Genomics of Chronic Allograft Rejection (GoCAR) is a multicenter study investigating the ability of gene expression to predict the development of Chronic allograft nephropathy.…
2017 American Transplant Congress
Nuclear Co-Repressor Complex Inhibition Reverses Benefit of HDAC2 Deletion in Renal Ischemia.
D. Aufhauser Jr,¹ D. Murken,¹ Z. Wang,¹ A. Samanta,² G. Ge,¹ T. Bhatti,³ P. Cole,⁴ J. Kalin,⁴ W. Hancock,^2,3 M. Levine.^1,5
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, University of Pennsylvania, Philadelphia, PA; ³Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ⁴Pharmacology and Molecular Sciences, Johns Hopkins University, Baltimore, MD; ⁵Surgery, Children's Hospital of Philadelphia, Philadelphia, PA
Introduction: Class I histone/protein deacetylases (HDACs) 1 and 2 bear >85% protein sequence homology and conventionally are thought to have similar function via occupancy in…
2017 American Transplant Congress
Worsening Rather Than Severe Acute Kidney Injury Affects Kidney Transplantation Outcomes.
M.-Y. Yu,¹ B. Yu,² Y. Kim,¹ S. Mi,³ J. Ha,³ J. Yang,³ Y. Kim,¹ H. Lee.¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; ²Internal Medicine, Soon Chun Hyang University Bucheon Hospital, Bucheon, Republic of Korea; ³Surgery, Seoul National University Hospital, Seoul, Republic of Korea
BackgroundThe growing evidence has suggested that deceased donor kidneys with acute kidney injury (AKI) may be a good solution to overcome organ shortage. Although previous…