ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft function"

  • 2017 American Transplant Congress

    Clinical Evaluation of the Safety and Preliminary Efficacy of Continuous Infusion of Treprostinil to Prevent Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients.

    O. Almazroo,1 M. Miah,1 V. Pillai,1 A. Humar,2 A. Tevar,2 C. Hughes,2 A. AlKhafaji,3 A. Demetris,4 S. Dermont,2 S. Fedorek,2 H. Johnson,1 R. Lopez,2 R. Planinsic,2 B. Sengupta,2 I. Sethu,2 M. Sturdevant,2 S. Ziobert,1 R. Venkataramanan.1,2,4

    1Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA; 2Thomas Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 3Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA; 4Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    Introduction:Liver transplantation is currently the only therapeutic option for patients with end stage liver diseases. Liver allografts undergo cold ischemic injury and warm reperfusion injury…
  • 2017 American Transplant Congress

    Ex Vivo Normothermic Perfusion of Isolated Segmental Porcine Bowel: A Novel Functional Model of the Small Intestine.

    M. Hamed,1 A. Barlow,1 S. Khosla,1 A. Sagar,1 F. Gribble,2 M. Murphy,3 G. Pettigrew,1 E. Bolton,1 J. Bradley,1 M. Nicholson,1 S. Hosgood,1 K. Saeb-Parsy.1

    1University Department of Surgery, Cambridge NIHR Biomedical Research Centre and NIHR Blood and Transplant Research Unit in Organ Donation and Transplantation, Cambridge, Cambridgeshire, United Kingdom; 2Wellcome Trust – MRC Institute of Metabolic Science, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 3MRC Mitochondrial Biology Unit, Cambridge, Cambridgeshire, United Kingdom

    Introduction: There is a need for the development of suitable large animal models for research in gastroenterology and intestinal transplantation. Ex vivo normothermic perfusion (EVNP)…
  • 2017 American Transplant Congress

    Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.

    A. Colovai, M. Ajaimi, N. Hayde, L. Kamal, S. Chan, C. Savchik, J. Rocca, E. Akalin.

    Surgery, Montefiore Medical Center, Bronx, NY

    The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…
  • 2017 American Transplant Congress

    Identifying Risk of Sepsis Early: A Way to Improve Outcomes for Patients with Early Allograft Dysfunction After Liver Transplantation?

    D. Hoyer, T. Benko, G. Sotiropoulos, A. Paul, F. Saner.

    General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany

    Early Allograft Dysfunction (EAD) after Liver Transplantation (LT) is associated with increased morbidity and mortality, which is strongly associated with sepsis/septic shock. Aim of this…
  • 2017 American Transplant Congress

    IP-10 Monoclonal Antibody Treatment Suppresses Inflammatory Components of IBMIR and Improves Pancreatic Islet Graft Function.

    G. Yoshimatsu,1 C. Chang,1 C. Darden,1 P. Saravanan,1 B. Naziruddin,2 M. Lawrence.1

    1Baylor Scott and White Reseasrch Institute, Dallas, TX; 2Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: An instant blood-mediated inflammatory response (IBMIR) causes acute loss of pancreatic islets. Interferon gamma-induced protein 10 (IP-10) is a key proinflammatory chemokine that may…
  • 2017 American Transplant Congress

    Analysis of Differences in Living Donor and Recipient Pairs Estimated GFR at Six Months Over Time.

    D. Keith.

    Medicine, Division of Nephrology, Sacred Heart Hospital, Pensacola, FL

    Previous studies of the United States Kidney Transplant Database revealed that the median estimated GFR (eGFR) has improved over the last decade for living donor…
  • 2017 American Transplant Congress

    Orthotopic Liver Transplantation of Xenogeneic Livers Repopulated with Autologous Hepatocytes: Proof of Normal Function and Consistent Survival.

    G. Oldani, S. Lacotte, L. Orci, V. Delaune, C. Toso.

    Geneva University Hospitals, Geneva, Switzerland

    BackgroundGeneration of transplantable patient-like organs in pigs will solve the problem of organ shortage and potentially extend the indications for liver transplantation. However, the efficacy…
  • 2017 American Transplant Congress

    Outcome of Systemic Monitoring of DSA and Protocol Management to Optimize Renal Allograft Outcome in a Single Transplant Center.

    S. Chang,1 I. Mallawaarachchi,2 C. Yip,1 T. Shanahan,3 A. Gundroo,1 A. Dwivedi,2 S. Patel,4 M. Zachariah.1

    1Internal Medicine, University of Buffalo, Buffalo, NY; 2Biomedical Sciences, Texas Tech University, El Paso, TX; 3IMMCO Diagnostics, Buffalo, NY; 4Surgery, University of Buffalo, Buffalo, NY

    Denovo (dn) donor specific antibody (DSA) development has been shown to adversely affect long-term allograft survival. To improve graft outcome for kidney (K) transplant (Tx)…
  • 2017 American Transplant Congress

    Prolonged Cold Ischemia Time as a Risk for Low Regeneration at the Early Phase After Living Donor Liver Transplantation.

    K. Takahashi,1,2 S. Nagai,1 M. Safwan,1 K. Putchakayala,1 M. Rizzari,1 K. Collins,1 A. Yoshida,1 G. Schnickel,1 M. Abouljoud.1

    1Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; 2Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan

    Background. The objective of this study was to determine the risk factors for low liver regeneration at the early phase after living donor liver transplantation…
  • 2017 American Transplant Congress

    Noninvasive Renal Transplant Graft Monitoring in Single Institution Using Cell-Free DNA in Recipient Plasma via Insertion-Deletion Allele Polymorphism.

    Y. Goh,1 S. Ho,2 L. Raman,1 V. Anantharaman,3 T. Goh,3 S. Koay,2 H. Tiong.1

    1Urology, National University Hospital, Singapore, Singapore; 2Laboratory Medicine, National University Hospital, Singapore, Singapore; 3Nephrology, National University Hospital, Singapore, Singapore

    IntroductionThere is an unmet clinical need in renal transplantation towards early detection of donor organ damage. Serum creatinine(SCr) and biopsies are not ideal.Cell-free donor DNA(cfdDNA)…
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