Articles tagged "Graft function"

2018 American Transplant Congress
Obese Patients Show Resistance to Narcotics Reduction after TPIAT for Chronic Pancreatitis
G. Yoshimatsu,¹ B. Naziruddin,³ K. Kumano,² H. Fernandez,³ E. Beecherl,³ N. Onaca.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for chronic pancreatitis patients with refractory pain. Patients with high BMI (>30) are known…
2018 American Transplant Congress
Long-Term Effects of Ketoconazole in Rapid Tacrolimus Metabolizers Post-Renal Transplantation
J. Ching,¹ S. Anders,¹ M. Janusek,¹ L. Hutchinson,¹ A. Freeman,¹ U. Patel,¹ A. Mohammed,⁴ H. Bohorquez.^2,3
¹Department of Pharmacy, Ochsner Clinical Foundation, New Orleans, LA; ²Multi-Organ Transplant Institute, Ochsner Clinical Foundation, New Orleans, LA; ³The University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA; ⁴Academic Center, Ochsner Clinical Foundation, New Orleans, LA.
Introduction: Genetic polymorphisms in cytochrome P-450 enzymes can cause variations in tacrolimus (tac) metabolism. Ketoconazole (keto), a potent CYP450 and P-glycoprotein inhibitor, can be used…
2018 American Transplant Congress
A Phase I/II, Double-Blind, Placebo-Controlled Study Assessing Safety and Efficacy of C1 Esterase Inhibitor for Prevention of Delayed Graft Function in Deceased Donor Kidney Transplant Recipients
S. Jordan,¹ J. Choi,¹ O. Aubert,² M. Haas,³ A. Loupy,² E. Huang,¹ A. Peng,¹ I. Kim,¹ S. Sethi,¹ S. Louie,¹ D. Puliyanda,¹ A. Vo.¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Paris Translational Research Center for Organ Transplantation, Necker Hospital, Paris, France; ³Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Delayed graft function (DGF)in kidney allograft recipients is traditionally defined as need for dialysis during the first week after transplantation. DGF is related to…
2018 American Transplant Congress
Delayed Graft Function in Simultaneous Liver Kidney Transplantation
S. Weeks,¹ X. Luo,¹ S. Ottmann,¹ A. Gurakar,² F. Naqvi,² B. Philosophe,¹ A. Cameron,¹ N. Desai,¹ D. Segev,¹ J. Garonzik Wang.¹
¹Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD; ²Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD.
Purpose: Increased rates of delayed graft function (DGF) after simultaneous liver kidney (SLK) transplantation have been described, as well as inferior graft survival in patients…
2018 American Transplant Congress
Acute Tubular and Glomerular Kidney Injury Markers Reflect Ischemia-Reperfusion and Rejection
Y. Shim, R. Fan, N. Dvorina, W. Baldwin.
Immunology, Cleveland Clinic, Cleveland, OH.
Reliable markers of early acute injury following renal transplantation would enable timely therapeutic interventions. Standard serum creatinine and blood urea nitrogen measurements increase only after…
2018 American Transplant Congress
Increased Risk of Early Graft Loss in Pancreas Transplant: A Retrospective Review of the UNOS Database
E. Steen,¹ C. Liu,² E. Siskind,² J. Ortiz.¹
¹Surgery, University of Toledo Medical Center, Toledo, OH; ²Surgery, Inova Fairfax Hospital, Annandale, VA.
Introduction: Pancreas transplant is an established cure for Type 1 diabetes. Nonetheless, early graft loss is not infrequent. We sought to analyze all of the…
2018 American Transplant Congress
Long-Term Outcomes of a Steroid-Free, Belatacept-Based Immunosuppressive Regimen Plus Sirolimus Using Alentuzumab Induction in Renal Transplantation
A. Guasch,¹ A. Ghali,¹ S. Mead,¹ A. Mehta,¹ H. Xu,² A. Kirk.²
¹Emory Transplant Center, Emory University, Atlanta, GA; ²Dept of Surgery, Duke University, Durham, NC.
The toxicities of CNIs and steroids have a negative impact on kidney transplantation. Belatacept is a safe, non-nephrotoxic alternative to CNIs, that may lead to…
2018 American Transplant Congress
Urinary Microbiome Associated with Chronic Allograft Dysfunction in Kidney Transplants
A. Israni,^1,2 A. Muthusamy,² B. Wu,³ B. Guo,³ D. Knights,⁴ G. Al-Ghalith,⁴ J. Wu,¹ W. Oetting,⁵ D. Schladt,² R. Remmel,⁵ P. Jacobson,⁵ For DeKAF Genomics & GEN03 Investigators.¹
¹Medicine, Hennepin County Medical Center, University of Minnesota (UMN), Minneapolis; ²Minneapolis Medical Research Foundation, Mpls; ³Biostatistics, UMN, Mpls; ⁴Computer Science, UMN, Mpls; ⁵College of Pharmacy, UMN, Mpls.
Background: Microbiome dysbiosis can lead to poor outcomes after kidney transplant (tx) presumably due to immune dysregulation elicited by the microbiome. We hypothesize that chronic…
2018 American Transplant Congress
Improving DCD Livers Graft Function Using CD47 Blockade in the Setting of Normothermic Liver Perfusion
S. Garcia-Aroz,¹ M. Xu,¹ X. Wang,¹ J. Hollingshead,¹ A. Khan,¹ B. Banan,¹ L. Kang,² Z. Zhang,¹ G. Upadhya,¹ Y. Lin,¹ P. Manning,³ W. Chapman.¹
¹Surgery, Washington University, St. Louis; ²Pathology, Washington University, St. Louis; ³Arch Oncology, St. Louis.
Background: Towards the goal of utilizing more livers for transplantation, transplant centers are looking to increase the use of organs from marginal donors. Livers from…
2018 American Transplant Congress
The Use of LiMAx for Evaluating Donor Livers on Normothermic Machine Perfusion
J. Schurink,¹ J. de Haan,² M. Verstegen,¹ H. Metselaar,³ J. Ijzermans,¹ J. de Jonge.¹
¹Surgery, Erasmus MC, Rotterdam, Zuid Holland, Netherlands; ²Intensive Care Medicine, Erasmus MC, Rotterdam, Zuid Holland, Netherlands; ³Gastroenterology, Erasmus MC, Rotterdam, Zuid Holland, Netherlands.
Due to the organ shortage, inferior quality livers from donors after circulatory arrest (DCD) are offered to relieve mortality on the waiting list. The threshold…