Articles tagged "Graft function"

2022 American Transplant Congress
Preclinical Evaluation of Functional Survival of Stem Cell Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression
M. C. Poznansky
Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestwon, MA
*Purpose: Human stem cell-derived islet-like cells (SC-islets) represent a sustainable source for beta-cell replacement to achieve a functional cure for type 1 diabetes. We previously…
2022 American Transplant Congress
Cold Ischemic Time and Kidney Graft Failure; Mediation Through Delayed Graft Function
J. Miller¹, W. Irish², D. Sawinski³, A. Massie⁴, J. Snyder¹
¹Scientific Registry of Transplant Recipients, Minneapolis, MN, ²Department of Surgery, East Carolina University, Greenville, NC, ³Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY, ⁴Division of Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) has been associated with decreased graft survival and prolonged cold ischemia time (CIT) has been proposed as a modifiable DGF…
2022 American Transplant Congress
Defects in Kim-1 Do Not Result In Delayed Graft Function After Kidney Transplantation
R. S. Suri¹, J. Lee², M. Ban³, B. Shrum², O. Z. Ismail⁴, S. Leckie⁵, A. McIntyre³, Q. Xu⁶, S. H. Lee², S. de Chickera², R. A. Hegele², L. Gunaratnam²
¹Research Institute of the McGill University Health Center, Montreal, QC, Canada, ²Schulich School of Medicine and Dentistry, Western University, Lodnon, ON, Canada, ³Robarts Research Institute, Lodnon, ON, Canada, ⁴University of Alberta, Edmonton, AB, Canada, ⁵London Health Sciences Centre, Lodnon, ON, Canada, ⁶University of Pittsburg Medical Center, Pittsburg, PA
*Purpose: Tissue repair is critical to restore organ function after ischemia-reperfusion injury (IRI) during transplantation. During renal injury, upregulation of kidney injury molecule-1 (KIM-1) transforms…
2022 American Transplant Congress
Biological Functions of Circulating miRNAs in Patients with Chronic Pancreatitis Undergoing Total Pancreatectomy with Islet Autotransplantation
S. Vasu¹, C. Darden², Y. Liu³, M. Lawrence⁴, B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University, Waco, TX, ³-Baylor University Medical Center, Dallas, TX, ⁴Baylor University Medical Center, Dallas, TX
*Purpose: Our previous reports showed that in patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after…
2022 American Transplant Congress
Intraoperative Kinetics of Pro-Inflammatory Markers and Delayed-Graft Function During Kidney Transplantation
P. A. Wadsworth, H. L. Stevenson, M. L. Kueht
University of Texas Medical Branch, Galveston, TX
*Purpose: Detailed molecular changes associated with allograft reperfusion have been poorly defined and current methods of predicting delayed graft function (DGF) after kidney transplantation are…
2022 American Transplant Congress
Acute Tubular Injury and Necrosis Do Not Lead to Meaningful Elevations in Donor-Derived Cell-Free DNA (dd-cfDNA)
S. R. Allam¹, M. Cooper², D. Kumar³, T. Maw⁴, A. Wiseman⁵, P. Chuang⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, E. Huang⁸
¹Medical City Transplant Institute, Fort Worth, TX, ²Medstar Georgetown Transplant Institute, Washington, DC, ³Virginia Commonwealth University, Richmond, VA, ⁴University of Southern California, Los Angeles, CA, ⁵Centura Health, Denver, CO, ⁶Metrolina Nephrology, Charlotte, NC, ⁷CareDx, Brisbane, CA, ⁸Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Associations between non-rejection histologic diagnoses and dd-cfDNA have not been extensively characterized. We explored these associations in kidney transplant recipients enrolled in the Kidney…
2022 American Transplant Congress
Timing of Hypotension Post Kidney Transplant Impacts the Risk of Subsequent Delayed Graft Function
S. A. Morrison¹, A. Thanamayooran², K. Tennankore¹, A. J. Vinson¹
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Hypotension is common post-kidney transplant and is associated with delayed graft function (DGF; a need for dialysis in the first week post-transplant) and prolonged…
2022 American Transplant Congress
The Correlation Between Kidney Donor Risk Index, Kidney Graft Function and Histological Changes in Early Post-Transplant Renal Biopsy
N. Slabiak-Blaz, A. Kujawa-Szewieczek, A. Kolonko, H. Karkoszka, A. Wiecek, G. Piecha
Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland
*Purpose: An appropriate assessment of donor organ quality is crucial to optimize the kidney allocation and improve the long-term outcomes. Kidney Donor Risk Index (KDRI),…
2022 American Transplant Congress
Prebiotic Supplementation In Kidney Transplant Recipients For Preventing Infections And Gastrointestinal Upset: A Randomized Controlled Feasibility Study
S. Chan¹, C. M. Hawley¹, E. M. Pascoe², C. Z. Cao², S. B. Campbell², K. L. Campbell³, R. S. Francis², R. Hale¹, N. M. Isbel⁴, M. Morrison⁵, D. W. Johnson²
¹Department of Nephrology, Princess Alexandra Hospital, Woolloongabba, Australia, ²Princess Alexandra Hospital, Woolloongabba, Australia, ³Menzies Health Institute - Molecular Basis of Disease Research Program, Griffith University, Brisbane, Australia, ⁴Princess Alexandra Hospital, Brisbane, Australia, ⁵Diamantina Institute, Faculty of Medicine, The University of Queensland, Woolloongabba, Australia
*Purpose: Modulating the large intestinal microbiome of kidney transplant recipients (KTR) may reduce infectious complications. The aim of this study was to assess the feasibility…
2022 American Transplant Congress
Kidney Grafts with Poor 24-Month Function Present Upregulated Immune Activity at Pre-Transplantation
E. Bardhi¹, K. Archer², D. Maluf¹, J. McDaniels¹, T. Rousselle¹, E. Akalin³, T. Mueller⁴, V. Mas¹
¹University of Maryland, Baltimore, MD, ²Ohio State University, Columbus, OH, ³Montefiore Medical Center, Bronx, NY, ⁴University Hospital Zürich, Zürich, Switzerland
*Purpose: A transcriptomic profile serves as a snapshot of the temporary cell state and thus, analyzing pretransplant kidney biopsies can provide detailed information on the…