ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft function"

  • 2022 American Transplant Congress

    Outcomes After Deceased Donor Kidney Transplantation Utilizing Kidney Allografts with Marginal Perfusion Parameters: A Single-Center Experience

    P. N. Chotai1, A. Logan2, F. Siddiqui3, A. Schenk4, G. Bumgardner5, G. L. Brock2, A. El-Hinnawi5, A. Rajab6, K. Washburn7, N. Singh2

    1Division of Transplantation, Department of General Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH, 3Ohio State University, Bloomfield, NJ, 4Ohio State University Wexner Medical Center, Bexley, OH, 5Ohio State University, Columbus, OH, 6Ohio State University Wexner Medical Center, Columbus, OH, 7The Ohio State University, Columbus, OH

    *Purpose: To study outcomes of deceased donor kidney transplantation (DDKT) in recipients of kidney allografts with poor perfusion parameters.*Methods: This is a retrospective, single center…
  • 2022 American Transplant Congress

    High Incidence Of Anti-HLA DSA And Late Allograft Dysfunction In Solid Organ Transplant Recipients Hospitalized With Covid-19

    J. T. Killian, S. Roman Soto, V. Hauptfeld-Dolejsek, E. B. Levitan, P. M. Porrett, V. Kumar, F. E. Lund, J. A. Houp

    University of Alabama at Birmingham, Birmingham, AL

    *Purpose: Solid organ transplant (SOT) recipients admitted for COVID-19 commonly experience immunosuppression reduction and acute allograft dysfunction. Given the number of SOT patients hospitalized for…
  • 2022 American Transplant Congress

    TNX-1500, an Fc-Modified Anti-cd154 Antibody, Prolongs Nonhuman Primate Cardiac Allograft Survival

    S. Miura1, Z. Abady1, F. Pollok1, M. Ma1, K. Kinoshita1, S. Fogarty2, P. Maguire2, B. Daugherty2, S. Lederman2, R. Pierson III1

    1Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA, 2Tonix Pharmaceuticals, Chatham, NJ

    *Purpose: Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to replace current clinical immunosuppression. TNX-1500 (TNX) is a novel humanized anti-CD154…
  • 2022 American Transplant Congress

    Impact of Varying Levels of Normal Range Baseline Donor Derived Cell Free DNA on Medium-Term Outcomes Following Kidney Transplantation

    K. K. Sureshkumar1, A. Grazier2, B. Chopra1

    1Nephrology, Medicine Institute, Allegheny General Hospital, Pittsburgh, PA, 2Abdominal Transplantation, Allegheny General Hospital, Pittsburgh, PA

    *Purpose: Donor derived cell free DNA (dd-cfDNA) is a biomarker with high negative predictive value for ruling out acute rejection (AR) in kidney allografts. Baseline…
  • 2022 American Transplant Congress

    Generation and Functional Characterization of Bio-Engineered Livers for Heterotopic Implantation in Porcine Model of Acute Liver Failure

    A. A. Katane1, B. P. Amiot2, A. R. Stumbras1, A. Mendenhall1, N. R. Palumbo1, A. C. Donepudi1, J. J. Ross1, S. L. Nyberg3

    1Miromatrix Medical Inc, Eden Prairie, MN, 2Department of Surgery, Mayo Clinic, Rochester, MN, 3William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN

    *Purpose: Liver transplantation has shown to be an effective therapy for the end-stage liver diseases (ESLD). However, as donor organ shortages increase, organ engineering technology…
  • 2022 American Transplant Congress

    Donor Terminal Creatinine – Does It Matter?

    V. G. Menon, Y. Wert, W. Hoffman, D. Ladie, M. Singh, M. Waybill, H. Yang

    UPMC, Harrisburg, PA

    *Purpose: When assessing deceased donor kidneys, the transplantation team studies several donor variables including creatinine. A creatinine that is elevated immediately prior to procurement can…
  • 2022 American Transplant Congress

    Renal Function at Five Years from a Randomized Multicenter Trial of Belatacept-Based CNI Free and Early Steroid Withdrawal Immunosuppression

    E. Yanqui1, H. Hames1, A. R. Shields1, T. Shi1, A. L. Christianson1, J. Kremer2, A. Govil1, R. R. Alloway1, E. S. Woodle1

    1University of Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH

    *Purpose: BENEFIT and BENEFIT EXT trials have demonstrated that belatacept-based immunosuppression was associated with improved long term renal allograft function compared to cyclosporine-based immunosuppression. Similar…
  • 2022 American Transplant Congress

    Conversion to Everolimus-Based Immunosuppression Regimen with Calcineurin Inhibitor Reduction Ameliorates Histological Damage in Kidney Transplant Recipients with Calcineurin Inhibitor-Induced Nephrotoxicity

    K. Hotta, N. Iwahara, T. Tanabe, N. Shinohara

    Hokkaido University Hospital, Sapporo, Japan

    *Purpose: In the last two decades, the short-term results for kidney transplantation (KTX) have improved owing to the use of calcineurin inhibitors (CNIs). However, long-term…
  • 2022 American Transplant Congress

    Baseline Levels and Early Post-Transplant Kinetics of Donor-Derived Cell-Free DNA Following Liver Transplantation

    S. Florman1, D. Axelrod2, J. Miles3, E. Vaskova3, D. Kilam3, K. Dhanireddy4, V. Subramanian4

    1Mount Sinai Medical Center, New York, NY, 2University of Iowa, Iowa City, IA, 3CareDx, South San Francisco, CA, 4Tampa General Hospital, Tampa, FL

    *Purpose: Non-invasive biomarkers in liver transplant (LT) are needed to improve detection of allograft injury in routine surveillance and during immunosuppression modulation, prior to the…
  • 2022 American Transplant Congress

    Association Between Histopathological Features on Implantation Renal Biopsies and Graft Outcomes and Kdpi

    C. Khor, S. McGinn, C. Fisher, R. Yang, K. Richards, K. Muir, J. Lu

    Nephrology, Royal North Shore Hospital, Sydney, Australia

    *Purpose: The global shortage of organs and the increasing use of marginal kidneys for transplantation necessitates an accurate assessment of deceased donor kidneys. The kidney…
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