Articles tagged "Graft function"

2019 American Transplant Congress
Intrinsic Organ Quality Assessment Using Integrative Short Outcome Prediction Composite Scores
K. Archer¹, V. Bontha², Y. Zhang¹, J. Eason³, A. Bajwa², L. Gallon⁴, E. Akalin⁵, D. Maluf², V. Mas⁶
¹OSU, Columbus, OH, ²UTHSC, Memphis, TN, ³UTHSC Director of Transplant Institute, Memphis, TN, ⁴NWU, Chicago, IL, ⁵Albert Einstein College of Medicine, NYC, NY, ⁶UTHSC Director of Transplant Research Institute, Memphis, TN
*Purpose: Organs discards continue to be high due to lack of accurate tools to assess donor quality and predict organ function.To identify characteristics associated with…
2019 American Transplant Congress
Meet Your Mate: Lessons Gleaned from Analysis of 154 Paired Kidneys Transplanted at a Single Center
M. Lubetzky¹, M. Aull², K. Rhee¹, S. Sultan², S. Kapur²
¹Division of Nephrology, New York, NY, ²Surgery, NYP-Weill Cornell, New York, NY
*Purpose: The factors affecting graft and patient survival are in many studies confounded by center and donor related factors. Mate kidney analyses can help to…
2019 American Transplant Congress
Effects of Proton Pump Inhibitors on Allograft Rejection and Adverse Effects in Kidney Transplant Recipients: A Systemic Review and Meta-Analysis
B. Boonpheng¹, C. Thongprayoon², M. A. Mao³, W. Cheungpasitporn⁴
¹Internal Medicine, East Tennessee State University, Johnson City, TN, TN, ²Nephrology, Mayo Clinic, Rochester, MN, MN, ³Nephrology, Mayo Clinic, Rochester, MN, ⁴Internal Medicine, University of Mississippi Medical Center, Jackson, MI, MS
*Purpose: The adverse renal effects of proton pump inhibitors (PPIs) are being increasingly recognized in both the general population and chronic kidney disease patients. Several…
2019 American Transplant Congress
Innate Immunity in Brain Dead Donors: Implications of Necroptosis in Kidney Allograft Outcomes
A. Ang¹, A. Zmijewska², T. M. Stevens³, J. Murphy¹, R. B. Mannon²
¹School of Medicine, UAB, Birmingham, AL, ²Medicine/Nephrology, UAB, Birmingham, AL, ³Pathology, UAB, Birmingham, AL
*Purpose: Regulated necrosis (necroptosis) has been implicated in renal injury from nephrotoxic agents and ischemia. With the use of suboptimal brain dead donors (BDDs) to…
2019 American Transplant Congress
One Study: A Consortium Model of Clinical Trials Optimized for Comparing New Immune Therapies via Centralized Immune Monitoring
B. Sawitzki¹, S. Schlickeiser¹, M. Streitz¹, K. Jürchott¹, J. Hutchinson², E. Geissler², P. Investigators³
¹Charite Universitätsmedizin, Berlin, Germany, ²University of Regensburg, Regensburg, Germany, ³ONE Study Consortium, EU, Germany
*Purpose: Immune regulatory cell subpopulations can potentially control immune responses to allow immunosuppression (IS) drug minimization. In the ONE Study, an EU FP7-funded research group…
2019 American Transplant Congress
Renal Outcomes from Expander-1: Pilot Study of HCV+ Donor Kidneys for HCV- Kidney Recipients
S. Thaduri¹, C. Durand¹, N. Desai², D. Segev², N. Bair¹, D. Brown¹, F. F. Naqvi¹
¹Medicine, -Johns Hopkins University, -Baltimore, MD, ²Surgery, -Johns Hopkins University, -Baltimore, MD
*Purpose: Direct acting antivirals (DAAs) have led to high cure rates (>95%) for hepatitis C. Utilization of HCV+ donor kidneys for patients with advanced kidney…
2019 American Transplant Congress
De Novo Belatacept to Delay Tacrolimus Initiation in Renal Transplants with Delayed Graft Function
A. Dao, A. Reyad, L. Kautzman, M. Madhrira, I. Memon, O. Elmhishi, B. Sankarapandian, J. Johnson, S. Patel, S. Allam
Medical City Fort Worth Transplant Institute, Fort Worth, TX
*Purpose: Delayed graft function (DGF) post renal transplant (RT) is associated with adverse patient and graft outcomes. Early tacrolimus (FK) initiation with high trough levels…
2019 American Transplant Congress
Primary Nonfunction after Kidney Transplantation is Associated with Elevated Donor Urinary Biomarkers
S. Mohan, P. Reese, I. Hall, M. Doshi, Y. Jia, H. T. Philbrook, E. Akalin, J. Bromberg, M. Harhay, S. Mansour, T. Muthukumar, B. Schröppel, P. Singh, F. Weng, C. Parikh
for the DDS Consortium, Baltimore, MD
*Purpose: Primary nonfunction (PNF) defined as dialysis dependent for 3 months post-transplant, is a rare but catastrophic outcome for recipients. PNF also negatively impacts transplant…
2019 American Transplant Congress
Does Proton Pump Inhibitor Use Affect Renal Function in Kidney Transplant Recipients?
K. Schütte-Nütgen¹, D. J. Flothow¹, B. Suwelack¹, R. Schmidt², H. Pavenstädt¹, S. Reuter¹
¹Department of Internal Medicine D, University Hospital Münster, Münster, Germany, ²Institute of Biostatistics and Clinical Research, University Hospital Münster, Münster, Germany
*Purpose: Recently, proton pump inhibitor (PPI) intake has been linked to acute kidney injury and chronic kidney disease. In the setting of renal transplantation, it…
2019 American Transplant Congress
Impact of T-cell Mediated Allograft Inflammation within First-Year after Kidney Transplantation: An Analysis of Paired Biopsies from a Single Center Study
S. Tandukar, R. Mehta, I. Owoyemi, D. Jorgensen, P. Sood, S. Hariharan
Division of Transplant Nephrology, Thomas E. Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We evaluated the impact of Clinical and Sub-Clinical T-Cell-Mediated Rejection (TCMR) and Sub-Clinical Inflammation (SCI) within 1 year post-transplant.*Methods: Adult kidney transplant patients who…