Articles tagged "Graft function"

2019 American Transplant Congress
Recombinant Apoptosis Inhibitor of Macrophage Protein Ameliorates Transplant Ischemia-Reperfusion Injury
J. Y. Lee¹, X. Zhang², D. Lian³, A. R. Haig⁴, T. Miyazaki⁵, L. Gunaratnam⁶
¹Department of Microbiology and Immunology, Western University, London, ON, Canada, ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada, ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, Lodnon, ON, Canada, ⁴Department of Pathology, Western University, London, ON, Canada, ⁵Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo, Japan, ⁶Department of Medicine, Western University, London, ON, Canada
*Purpose: Ischemia-reperfusion injury (IRI) during kidney transplantation is associated with acute rejection and long-term graft loss. During IRI, pro-inflammatory mediators (e.g. HMGB1) released from necrotic…
2019 American Transplant Congress
Urinary Podocin mRNA as Predictor of Renal Allograft Function Decline
A. Naik¹, J. Aqeel¹, D. Cibrik², M. Samaniego³, L. Wickman¹, S. Wang¹, M. Chowdhury¹, R. Wiggins¹
¹University of Michigan, Ann Arbor, MI, ²University of Kansas, Kansas City, KS, ³Henry Ford, Detroit, MI
*Purpose: Traditional biomarkers (such as proteinuria, 1year eGFR) as well as validated risk prediction tools such as the Birmingham Risk Score predict risk of ESRD.…
2019 American Transplant Congress
Basiliximab vs. Low-Dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patients: Prospective Randomized Study in Southeastern Mexico
G. Martinez-Mier, P. I. Moreno-Ley, L. F. Budar-Fernandez, M. T. Mendez-Lopez, D. A. Barrera-Amoros, M. De la Paz-Roman, L. A. Jimenez-López, E. G. Aguilar-Sandoval, C. A. Allende-Castellanos
Organ Transplantation & Research, IMSS UMAE HE 14, Veracruz, Mexico
*Purpose: Demonstrate that low dose Thymoglobulin (3 mg/kg total ) has similar efficacy (DGF, SGF, BPAR, hospitalizations, adverse events, graft loss and death) than Basiliximab…
2019 American Transplant Congress
Development of a Novel Linear Model for Predicting Recipient’s Post-Transplant Serum Creatinine Level after Living Donor Kidney Transplantation: A Multicenter Cross-Validation Study
S. Kim, S. Kim, J. Rhu, Y. Chung, S. Lee, K. Lee, J. Kim, G. Choi, J. Park, S. Lee, J. Joh
Transplantation, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: This study was designed to develop and cross-validate a statistical model for predicting post-transplant serum creatinine of living donor kidney transplantation.*Methods: Adult recipients of…
2019 American Transplant Congress
The Effect Of Missed Hemodialysis Treatment Prior To Transplant
A. Padiyar¹, A. Agrawal¹, D. Hricik¹, N. Sarabu¹, A. Jittirat¹, K. Yadav², E. Sanchez², M. Debroy², V. Humphreville², J. Rabets², A. Palanisamy², K. Chavin²
¹Medicine, Nephrology, University Hospitals Cleveland Medical Center, Cleveland, OH, ²Transplant Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: Missed hemodialysis sessions confer heightened morbidity and mortality for ESRD patients. The effect of missed dialysis in the month prior to transplant on the…
2019 American Transplant Congress
Comparison of Simultaneous Pancreas kidney Transplantation to Kidney Transplantation Alone for Type 2 Diabetes with End Stage Renal Disease
Y. Fu, Z. Shen
Kidney&Pancreas Transplant, Tianjin First Center Hospital, Tianjin, China
*Purpose: To compare the clinic outcomes of simultaneous pancreas-kidney transplantation (SPK) with kidney transplantation alone (KTA) in Type 2 Diabetes patients with ESRD.*Methods: 97 type…
2019 American Transplant Congress
Increase in Deceased Donor Acceptance Rate After Implementing Uniform Acceptance Criteria
C. Klein, T. Ommert, J. Hundley, J. Lizcano, A. Ray, R. Cross, K. Payne
Piedmont Transplant Institute, Atlanta, GA
*Purpose: Over 100,000 candidates are listed for kidney transplant in the United States, yet less than 20,000 patients are transplanted annually. In 2013, over 2,500…
2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
P. Saravanan¹, M. Kanak¹, G. Yoshimatsu², C. Darden², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
2019 American Transplant Congress
Functional Dependence, Access to Kidney Transplantation and Waitlist Mortality
A. Muzaale¹, N. Chu¹, H. Ying¹, S. Norman², S. Sison¹, D. Segev¹, M. McAdams-Demarco¹
¹JHU, Baltimore, MD, ²UM, Ann Habor, MI
*Purpose: Among patients with ESRD, functional dependence is common and an important determinant of both HRQOL and adverse outcomes. Kidney transplant (KT) may help patients…
2019 American Transplant Congress
Impact Of Rituximab And Maintenance Steroid In The Recurrence Of Focal Segmental Glomerulosclerosis
L. A. Mendez Castaner
Transplant, Miami Transplant Institute-University of Miami, Miami, FL
*Purpose: Recurrence of focal segmental glomerulosclerosis (FSGS) has been reported between 20-80% with up to 60% of graft loss. Rituximab has demonstrated to be effective…