Articles tagged "Graft function"

2019 American Transplant Congress
One Study: A Consortium Model of Clinical Trials Optimized for Comparing New Immune Therapies via Centralized Immune Monitoring
B. Sawitzki¹, S. Schlickeiser¹, M. Streitz¹, K. Jürchott¹, J. Hutchinson², E. Geissler², P. Investigators³
¹Charite Universitätsmedizin, Berlin, Germany, ²University of Regensburg, Regensburg, Germany, ³ONE Study Consortium, EU, Germany
*Purpose: Immune regulatory cell subpopulations can potentially control immune responses to allow immunosuppression (IS) drug minimization. In the ONE Study, an EU FP7-funded research group…
2019 American Transplant Congress
Renal Outcomes from Expander-1: Pilot Study of HCV+ Donor Kidneys for HCV- Kidney Recipients
S. Thaduri¹, C. Durand¹, N. Desai², D. Segev², N. Bair¹, D. Brown¹, F. F. Naqvi¹
¹Medicine, -Johns Hopkins University, -Baltimore, MD, ²Surgery, -Johns Hopkins University, -Baltimore, MD
*Purpose: Direct acting antivirals (DAAs) have led to high cure rates (>95%) for hepatitis C. Utilization of HCV+ donor kidneys for patients with advanced kidney…
2019 American Transplant Congress
De Novo Belatacept to Delay Tacrolimus Initiation in Renal Transplants with Delayed Graft Function
A. Dao, A. Reyad, L. Kautzman, M. Madhrira, I. Memon, O. Elmhishi, B. Sankarapandian, J. Johnson, S. Patel, S. Allam
Medical City Fort Worth Transplant Institute, Fort Worth, TX
*Purpose: Delayed graft function (DGF) post renal transplant (RT) is associated with adverse patient and graft outcomes. Early tacrolimus (FK) initiation with high trough levels…
2019 American Transplant Congress
Primary Nonfunction after Kidney Transplantation is Associated with Elevated Donor Urinary Biomarkers
S. Mohan, P. Reese, I. Hall, M. Doshi, Y. Jia, H. T. Philbrook, E. Akalin, J. Bromberg, M. Harhay, S. Mansour, T. Muthukumar, B. Schröppel, P. Singh, F. Weng, C. Parikh
for the DDS Consortium, Baltimore, MD
*Purpose: Primary nonfunction (PNF) defined as dialysis dependent for 3 months post-transplant, is a rare but catastrophic outcome for recipients. PNF also negatively impacts transplant…
2019 American Transplant Congress
Comparison of Oral Microbiome in Stable vs Declining Kidney Function in Renal Transplant Recipients
J. Wu¹, A. Muthusamy², G. Al-Ghalith³, B. Wu⁴, B. Guo⁴, W. Guan⁴, D. Knights³, W. Oetting⁵, D. Schladt², R. Remmel⁵, P. Jacobson⁵, A. K. Sharma⁶, A. Matas⁷, A. Israni¹, D. Skaar⁸
¹Nephrology, Hennepin Healthcare, Minneapolis, MN, ²Hennepin Health Research Institute, Minneapolis, MN, ³Computer Science, University of Minnesota, Minneapolis, MN, ⁴Biostatistics, University of Minnesota, Minneapolis, MN, ⁵Pharmacy, University of Minnesota, Minneapolis, MN, ⁶Animal Science, University of Minnesota, Minneapolis, MN, ⁷Surgery, University of Minnesota, Minneapolis, MN, ⁸Denistry, University of Minnesota, Minneapolis, MN
*Purpose: Transplantation causes dysbiosis of the oral microbiome of renal transplant recipients and has been correlated with worse allograft outcomes. We hypothesize that there are…
2019 American Transplant Congress
Impact of T-cell Mediated Allograft Rejection and Antibody Mediated Rejection within the First Year after Kidney Transplantation
I. Owoyemi, D. Jorgensen, S. Tandukar, R. Mehta, S. Hariharan
Thomas E. Starzl Institute of Transplantation and Division of Transplant Nephrology, UPMC, Pittsburgh, PA
*Purpose: This study evaluated the impact of Clinical and Sub-clinical T-Cell-Mediated Rejection (TCMR), Sub-Clinical Inflammation and Antibody Mediated Rejection (ABMR) within the 1st year post-kidney…
2019 American Transplant Congress
Predicting Metabolic Outcomes in Islet Autotransplantation before Transplantation
M. A. Kanak, P. Saravanan, J. Kalivarathan, Y. Shindo, M. F. Levy
Virginia Commonwealth University, Richmond, VA
*Purpose: Total Pancreatectomy with Islet Auto-transplantation (TPIAT) has been actively performed on patients with severe, debilitating pain of chronic pancreatitis. The outcome of islet transplantation…
2019 American Transplant Congress
Prevention of Graft Ischemia-Reperfusion Injury in Ischemia-Free Liver Transplantation
Z. Guo, X. He, Q. Zhao, S. Huang, Z. Zhang, L. Wang, W. Ju, G. Chen
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Graft ischemia-reperfusion injury (IRI) is an inevitable event in organ transplantation, which often leads to a number of complications and even patient deaths. We…
2019 American Transplant Congress
Differences of Gut Microbiota Composition between Donor and Recipient May Predict 1-Year Graft Function
J. Kim¹, H. Cho², J. Park³, J. Jeong¹, M. Kwak⁴, B. Kim⁴, D. Kim¹, J. Lee⁵, B. Kim⁶, Y. Kim¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Chungbuk National University Hospital, Cheongju, Korea, Republic of, ³Kangwon National University Hospital, Seoul, Korea, Republic of, ⁴Chunlab Inc., Seoul, Korea, Republic of, ⁵Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Signals derived from gut microbiota are critical for the development and maintenance of the human immune system. In view of kidney transplantation (KT), allograft…
2019 American Transplant Congress
Illustration of Renal Recovery in SLK with Utilization of Most Recent Allocation Criteria
B. Patel, R. Prashar, A. Babu
Henry Ford Hospital Detroit, Detroit, MI
*Purpose: Single Center review of Renal recovery in Simultaneous Liver Kidney Transplantation (SLKT) in patients who were approved for SLK based on the recent UNOS…