Articles tagged "Graft function"

2019 American Transplant Congress
Analysis of Islet Exosomal miRNAs Released Post-Transplant in Response to Inflammation
P. Saravanan¹, M. Kanak¹, G. Yoshimatsu², C. Darden², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Research Center, Dallas, TX
*Purpose: Islets release miRNAs and other non-coding RNAs via exosomes under various pathological conditions, which are capable of regulating the genes of neighboring and/or distant…
2019 American Transplant Congress
Functional Dependence, Access to Kidney Transplantation and Waitlist Mortality
A. Muzaale¹, N. Chu¹, H. Ying¹, S. Norman², S. Sison¹, D. Segev¹, M. McAdams-Demarco¹
¹JHU, Baltimore, MD, ²UM, Ann Habor, MI
*Purpose: Among patients with ESRD, functional dependence is common and an important determinant of both HRQOL and adverse outcomes. Kidney transplant (KT) may help patients…
2019 American Transplant Congress
Impact Of Rituximab And Maintenance Steroid In The Recurrence Of Focal Segmental Glomerulosclerosis
L. A. Mendez Castaner
Transplant, Miami Transplant Institute-University of Miami, Miami, FL
*Purpose: Recurrence of focal segmental glomerulosclerosis (FSGS) has been reported between 20-80% with up to 60% of graft loss. Rituximab has demonstrated to be effective…
2019 American Transplant Congress
Clinical Outcomes and Risk Factors for Delayed or Slow Graft Function in an Adult, Urban Renal Transplant Population
K. Tejani, Z. Hajjiri, E. Benedetti, A. Lichvar
University of Illinois at Chicago, Chicago, IL
*Purpose: Delayed graft function (DGF) and slow graft function (SGF) are shown to be associated with higher risk of rejection and suboptimal allograft function over…
2019 American Transplant Congress
Prolonged Heterotopic Cardiac Xenograft Survival from Thrombomudulin Expressing Multigene Donor Pig
A. K. Singh¹, L. DiChiacchio¹, T. Zhang¹, A. Hersfield¹, I. Tatarov¹, D. Parsell¹, B. Lewis¹, F. Sentz¹, D. Ayares², M. Mohiuddin¹
¹Department of Surgery, University of Maryland Baltimore, Baltimore, MD, ²Revivicor, Inc, Blacksburg, VA
*Purpose: Genetic engineering (GE) technology has made knockout and multigene expressing animals available. These animals can be used for xenotransplantation (xTX)to treat end stage diseases.…
2019 American Transplant Congress
The Use of High Volume Perioperative Normal Saline Increases the Risk of Delayed Graft Function after Kidney Transplantation
K. Kolodzie¹, O. S. Cakmakkaya², E. S. Boparai³, M. Tavakol⁴, J. Feiner¹, C. U. Niemann⁵
¹Anesthesia & Perioperative Care, University of California San Francisco, San Francisco, CA, ²Dept. of Medical Education, University Istanbul – Cerrahpasa, Istanbul, Turkey, ³School of Medicine, George Washington University, Washington, DC, ⁴Dept. of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA, ⁵Anesthesia & Perioperative Care, and Dept. of Surgery, Division of Transplantation, University of California San Francisco, San Francisco, CA
*Purpose: Metabolic and physiologic effects of high volume perioperative Normal Saline (NS) resuscitation are well described, but the impact on delayed graft function (DGF) remains…
2019 American Transplant Congress
Increase in Deceased Donor Acceptance Rate After Implementing Uniform Acceptance Criteria
C. Klein, T. Ommert, J. Hundley, J. Lizcano, A. Ray, R. Cross, K. Payne
Piedmont Transplant Institute, Atlanta, GA
*Purpose: Over 100,000 candidates are listed for kidney transplant in the United States, yet less than 20,000 patients are transplanted annually. In 2013, over 2,500…
2019 American Transplant Congress
Exosomes Carry Stress and Damage Specific miRNAs during Peritransplant Period in TPIAT
P. Saravanan¹, M. Kanak¹, S. Vasu², M. Lawrence², M. Levy¹, B. Naziruddin³
¹Department of Surgery, Virginia Commonwealth University, VCU Health, Richmond, VA, ²Islet Cell Lab, Baylor Scott and White Research Institute, Dallas, TX, ³Simmons Transplant Institute, Baylor Scott and White Medical Center, Dallas, TX
*Purpose: Innate inflammation and hypoxia during peritransplant period significantly affect survival of islet grafts. Markers that can identify stress and/or damage during this early period…
2019 American Transplant Congress
The Value of SCS Perfusate Biomarkers for Predicting DGF of DCD Donor Kidneys
X. Li, W. Wang, X. Zhang
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: To explore the possibilities of simple cold stored(SCS) perfusate biomarkers predicting delayed graft function(DGF) in donor of cardiac death (DCD) kidneys.*Methods: A total of…
2019 American Transplant Congress
Long-Term Outcomes and Safety of Living Kidney Transplantation from Older Donors
Y. Kakuta¹, M. Okumi¹, T. Kanzawa¹, K. Unagami², H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Tokyo, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Tokyo, Japan
*Purpose: The shortage of deceased donors and increase in the aging population have led to increased kidney transplantation using older living donors (LDs) in Japan,…