Articles tagged "Graft function"

2022 American Transplant Congress
Evs from Patients with Amr Induce Tubular Senescence and Endmt Through Horizontal Transfer of Mirnas
R. Franzin¹, A. Stasi¹, F. Sallustio¹, S. Bruno², G. Merlotti³, M. Quaglia³, G. Grandaliano⁴, P. Pontrelli¹, J. Thurman⁵, G. Camussi², G. Stallone⁶, V. Cantaluppi³, L. Gesualdo¹, G. Castellano⁷
¹DETO, University of Bari, Bari, Italy, ²University of Turin, Turin, Italy, ³University of Piemonte Orientale, Novara, Italy, ⁴Università Cattolica Sacro Cuore, Rome, Italy, ⁵University of Colorado School of Medicine, Aurora, CO, ⁶University of Foggia, Foggia, Italy, ⁷University of Milan, Milan, Italy
*Purpose: Extracellular vesicles (EV) are emerging mediators in several diseases; however, their role in antibody-mediated allograft rejection (AMR) has been poorly investigated.*Methods: Plasma EVs from…
2022 American Transplant Congress
Discovery of Risk Factor Control Targets Using Machine Learning and Network Analysis for One-Year Renal Allograft Dysfunction
Y. Lee¹, M. Hong², J. Kong³, O. Kwon⁴, C. Jung⁵, J. Yang⁶, M. Kim⁷, H. Han⁸, S. Nam⁹
¹Division of Nephrology, Department of Internal medicine, CHA Bundang Medical Center, Seongnam, Korea, Republic of, ²Department of Biomedical Informatics,, CHA University School of Medicine, Seongnam, Korea, Republic of, ³Department of Nephrology,, BHS Hanseo Hospital, Pusan, Korea, Republic of, ⁴Department of Surgery, College of Medicine, Han Yang University, Seoul, Korea, Republic of, ⁵Department of Surgery, Korea University Anam Hospital, Seoul, Korea, Republic of, ⁶Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁷Department of Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁸Department of Biomedical Informatics, CHA University School of Medicine, CHA University, Seongnam, Korea, Republic of, ⁹Department of Ophthalmology, CHA Bundang Medical Center, Seongnam, Korea, Republic of
*Purpose: Early identification of graft loss risk and timely therapeutic intervention are crucial for preventing late renal allograft failure and improving long-term graft function. This…
2022 American Transplant Congress
The Impact of Donor’s Metabolic Syndrome Factor on Living Kidney Transplantation
Y. Miyauchi, T. Noda, N. Miura, T. Kikugawa, T. Saika
Ehime University, Toon, Japan
*Purpose: Because donors for kidney transplantation are also aging in Japan, it is not uncommon that donors have metabolic syndrome (Met-S). It is necessary to…
2022 American Transplant Congress
Impact of Early Corticosteroid Withdrawal on Simultaneous Pancreas-Kidney Transplant Long-Term Outcomes: Single Center Experience and Comparison to the International Pancreas Transplant Registry
D. Pierce¹, A. Lichvar², A. Gruessner³, I. Tang¹, P. DiCocco¹, M. Spaggiari¹, I. Tzvetanov⁴, E. Benedetti¹, M. Campara¹
¹University of Illinois at Chicago, Chicago, IL, ²University of California San Diego Health, San Diego, CA, ³SUNY Downstate Medical Center, Brooklyn, NY, ⁴University of Illinios at Chicago, Chicago, IL
*Purpose: The purpose of this study is to assess the long-term efficacy and safety of early corticosteroid withdrawal (ESW) compared to corticosteroid maintenance (CCS) immunosuppression…
2022 American Transplant Congress
Lipid Metabolism Profile of Human Kidneys During Ex Vivo Normothermic Perfusion
J. Yu, I. Palma, S. Adams, J. Sageshima, P. Than, R. Perez
UC Davis Medical Center, Sacramento, CA
*Purpose: The kidney is a highly metabolic organ and lipids are an important energy source. In this study, we examined the lipid profiles of discarded…
2022 American Transplant Congress
DCD and AKI Kidneys Experiencing DGF as a Platform for the Study of Adaptive Repair
B. Bussolati¹, S. Da Sacco², A. Asthana³, L. N. Byers³, L. Perin⁴, M. S. Garner³, B. Sharda³, A. C. Farney³, C. J. Jay³, R. J. Stratta³, S. J. Walker⁵, G. Orlando³
¹University of Turin, Turin, Italy, ²Children Hospital Los Angeles, Los Angeles, NC, ³Wake Forest Baptist Medical Center, Winston-Salem, NC, ⁴Children Hospital Los Angeles, Los Angeles, CA, ⁵WFIRM, Winston-Salem, NC
*Purpose: AKI and DCD renal allografts are at high risk for DGF, yet the majority of these kidneys will eventually recover and attain good function…
2022 American Transplant Congress
Results Of The Ctot19 Trial: Infliximab (IFX) Induction Does Not Impact 2-year Outcomes In Deceased Donor Kidney Transplant Recipients
P. Heeger¹, B. Armstrong², T. Alhamad³, D. Brennan⁴, J. Bromberg⁵, S. Bunnapradist⁶, S. Chandran⁷, R. Fairchild⁸, D. Foley⁹, R. Formica¹⁰, I. W. Gibson¹¹, D. Hricik¹², K. Kesler², R. B. Mannon¹³, M. Menon¹⁰, K. Newell¹⁴, P. Nickerson¹¹, J. Odim¹⁵, E. Poggio⁸, R. Sung¹⁶, R. Shapiro¹, K. Tinckam¹⁷, F. Vincenti⁷
¹Mount Sinai, New York, NY, ²Rho, Durham, NC, ³Washington U, Saint Louis, MO, ⁴Johns Hopkins, Baltimore, MD, ⁵U Maryland, Baltimore, MD, ⁶UCLA, Los Angeles, CA, ⁷UCSF, San Francisco, CA, ⁸Cleveland Clinic, Cleveland, OH, ⁹U Wisconsin, Madison, WI, ¹⁰Yale, New Haven, CT, ¹¹U Manitoba, Winnipeg, MB, Canada, ¹²U Hosp Case, Cleveland, OH, ¹³U Nebraska, Omaha, NE, ¹⁴Emory, Atlanta, GA, ¹⁵NIAID NIH, Rockville, MD, ¹⁶U Michigan, Ann Arbor, MI, ¹⁷U Hlth Network, Toronto, ON, Canada
*Purpose: Ischemia-reperfusion (IR) of a kidney transplant (KTx) up-regulates tumor necrosis factor alpha (TNF) production within the allograft. IR-induced TNF amplifies post-KTx allograft inflammation and…
2022 American Transplant Congress
Single Kidney Transplantation Using Pediatric Donor Kidneys: Satisfactory Outcomes but Specific Attentions Needed
M. Huang, W. Wu, X. Su, J. Li, C. Wu, H. Zhang, Q. Fu, J. Li, S. Wu, Y. Chen, Q. Zhang, L. Liu, C. Wang
The First Affiliated Hospital Of Sun Yat-sen University, Guangzhou, China
*Purpose: Utilization of pediatric donor in single kidney transplantation (SKT) are popular and can greatly expand the scarce donor pool, whereas potential risk factors remain…
2022 American Transplant Congress
Association of Circulating microRNAs with Fibrosis and Metabolic Outcomes in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation
S. Vasu¹, G. Saracino², Y. Liu², J. Mattke³, C. Darden³, M. C. Lawrence², B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX
*Purpose: In patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after TPIAT. We selected a panel…
2022 American Transplant Congress
The Role of T Lymphocyte Subsets in Kidney Transplantation
L. Vagiotas¹, A. Xochelli², E. Sampani³, V. Nikolaidou², D. Asouchidou², E. Kasimatis³, N. Antoniadis¹, M. Daoudaki⁴, M. Stangou³, A. Papagianni³, G. Tsoulfas¹, A. Fylaktou²
¹Division of Organ Transplantation, Department of Surgery, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ²National Peripheral Histocompatibility Center, Immunology Department, Hippokration Hospital, Thessaloniki, Greece, ³Department of Nephrology, Aristotle University Medical School, Hippokration Hospital, Thessaloniki, Greece, ⁴Laboratory of Biological Chemistry, Faculty of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece
*Purpose: Impairment of cellular immune function in kidney transplant candidates is not concomitantly restored with the recovery of renal function, as alloimmune response and implementation…