2021 American Transplant Congress
Dual Lactate Clearance in the Liver Viability Assessment During Normothermic Machine Perfusion
*Purpose: Liver normothermic machine perfusion (NMP) has been increasingly performed as a tool of organ preservation and to evaluate donor function. The perfusate lactate clearance…2021 American Transplant Congress
Predicting Post-transplant Death and Graft Loss Risk: Insight at Listing
1CareDx, Brisbane, CA, 2Saint Louis University, St. Louis, MO
*Purpose: Prognostication models for post-transplant outcomes deriving inputs from information collected on donor (DDR/LDR), candidate (TCR) and transplant recipient (TRR) registrations can provide useful information…2021 American Transplant Congress
Efficacy of Ex Vivo Normothermic Limb Perfusion in Maintaining Cellular Viability and Muscle Function
*Purpose: The purpose of this study was to evaluate cellular injury and myocyte function of amputated limbs following ex vivo normothermic limb perfusion (EVNLP) compared…2021 American Transplant Congress
Role of Serial Donor Derived Cell-Free DNA Monitoring in Kidney Transplant Recipients
Nephrology, Stanford University School of Medicine, Palo Alto, CA
*Purpose: Donor derived cell-free DNA (dd cf-DNA; Allosure, CareDx) is increasingly employed for non-invasive kidney transplant monitoring. The goal of this study was 1) to…2021 American Transplant Congress
Dynamic Forecasting of Patient-Specific Kidney Transplant Function with a Sequence-to-Sequence Deep-Learning Model
*Purpose: Alike other clinical biomarkers, eGFR trajectories are characterized by intra-individual variability, related to biological fluctuations and analytical error. These fluctuations hamper the distinction between…2021 American Transplant Congress
Donor-derived Cell-free DNA Distinguishes Acute Rejection from Other Causes of Graft Injury in Liver Transplant Recipients
*Purpose: The donor derived cell-free DNA (ddcfDNA) has emerged as strong biomarker for allograft injury, where the fraction of ddcfDNA is reported to increase in…2021 American Transplant Congress
Tissue Specific Antigen-presentation in VCA Transplantation
*Purpose: Vascular Composite Tissue Allotransplantation (VCA) has become a clinical reality. High frequencies of acute rejections remain an unsolved problem. Here, we delineated components of…2021 American Transplant Congress
Clinical Effect of Post-transplant Av-fistula Ligation on Hemodynamic Status and Kidney Allograft Function
Nephrology, Indiana University, Indianapolis, IN
*Purpose: Ligation of AVF post kidney transplant often done mostly for esthetic reasons, however, they are occasionally indicated in the presence severe steal syndrome, severe…2021 American Transplant Congress
Donor-Derived Cell-Free DNA Can Differentiate Rejection versus Other Causes of Pancreas Transplant Dysfunction
1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, CA
*Purpose: Assessment and early detection of allograft injury in simultaneous pancreas and kidney (SPK) transplant recipients has clear benefits for optimizing treatment and intervention. Donor-derived…2021 American Transplant Congress
Development of Diagnosis Method of Acute Graft Rejection After Kidney Transplantation Using Metabolome Analysis by Liquid Biopsy Approach
*Purpose: Presently, a definitive diagnosis of organ dysfunction after transplantation (such as acute rejection) is dependent on conventional histopathological evaluation using an invasive biopsy procedure…
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