Articles tagged "Graft failure"

2021 American Transplant Congress
Oxalate Nephropathy After Kidney Transplant: Defining Histological Patterns, Contributing Factors and Graft Outcome
N. Jakob¹, A. Chuu¹, J. Ninan¹, E. Lim¹, N. Zhang¹, H. Amer², F. Cosio², H. Wadei³, M. Ryan¹, C. Cortese³, L. Cornell², M. Keddis¹
¹Nephrology, Mayo Clinic, Scottsdale, AZ, ²Nephrology, Mayo Clinic, Rochester, MN, ³Nephrology, Mayo Clinic, Jacksonville, FL
*Purpose: The objective of this study is to evaluate KTx recipients with biopsy proven oxalate nephropathy (ON) to better define risk factors, histologic patterns and…
2021 American Transplant Congress
Effect of Defibrotide on Kidney Ischemia Reperfusion Injury in a Preclinical Renal Transplant Model
P. Pine¹, Z. Sun², A. Matas³, J. Shi¹, A. Ebrahimnejad¹, M. Zanette⁴, P. Halloran⁵, J. S. Bromberg⁶, R. Hanvesakul⁷
¹Jazz Pharmaceuticals, Palo Alto, CA, ²Johns Hopkins Medicine, Baltimore, MD, ³Univ of Minnesota, Minneapolis, MN, ⁴Jazz Pharmaceuticals, Philadelphia, PA, ⁵Univ of Alberta, Edmonton, AB, Canada, ⁶Univ of Maryland School of Medicine, Baltimore, MD, ⁷Jazz Pharmaceuticals, Oxford, United Kingdom
*Purpose: Ischemia reperfusion injury (IRI) is a major contributor to graft failure. During organ removal and preservation, ischemia results in anaerobic respiration and cellular damage.…
2021 American Transplant Congress
The Importance of Persistent and Recurrent T Cell Mediated Rejection in Tacrolimus Treated Renal Transplant Recipients
C. Rampersad¹, I. W. Gibson², D. N. Rush¹, D. Pochinco³, P. E. Birk⁴, A. Goldberg⁴, T. Blydt-Hansen⁵, M. Karpinski¹, J. Shaw¹, J. Ho¹, P. W. Nickerson¹, C. Wiebe¹
¹Department of Medicine, University of Manitoba, Winnipeg, MB, Canada, ²Department of Pathology, University of Manitoba, Winnipeg, MB, Canada, ³Shared Health Services Manitoba, Winnipeg, MB, Canada, ⁴Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, ⁵Department of Pediatrics, University of British Columbia, Winnipeg, MB, Canada
*Purpose: Optimal follow-up after treatment for T-cell mediated rejection (TCMR) is not well-established. We sought to identify the prevalence and clinical associations of repeated TCMR…
2021 American Transplant Congress
Kidney Donor Risk Index: Significance as a Predictor of Kidney Transplant Outcomes Beyond Allograft Survival, Analysis of 18 Adjusted Regression Models Involving Adult Deceased Donor Kidney Recipients
A. Santos, E. Bueno, M. A. Leghrouz
University of Florida, Gainesville, FL
*Purpose: We aimed to study the role of kidney donor recipient index (KDRI) as a predictor for multiple transplant-related outcomes in adult deceased-donor (DD) kidney…
2021 American Transplant Congress
Donor Derived Cell-free-dna (dd-cfdna) as a Surrogate Marker for Kidney Biopsy- Indiana University Transplant Nephrology Experience
S. Valavoor¹, A. Sharfuddin², G. William³, M. Yaqub¹, D. Mishler¹, O. Adebiyi²
¹Nephrology, Indiana University, Indianapolis, IN, ²Transplant Nephrology, Indiana University, Indianapolis, IN, ³Transplant Surgery, Indiana University, Indianapolis, IN
*Purpose: Patient monitoring after kidney transplantation (KT) for early detection of allograft rejection remains key in preventing allograft loss. Donor-derived cell-free DNA (dd-cfDNA), a noninvasive…
2021 American Transplant Congress
Is Low Systemic Fibrinolytic Activity During the Anhepatic Phase Liver Transplant Surgery Associate with the Dreaded Post-Operative Complication of Hepatic Artery Thrombosis?
H. B. Moore¹, Y. Bababekov¹, J. Pomposelli¹, T. Ferrell¹, F. Azam¹, M. Adams², D. Yoeli¹, R. Choudhury¹, M. Wachs², E. Pomfret¹, T. Nydam¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital Colorado, Aurora, CO
*Purpose: Removal of the native liver during transplantation results in impaired clearance of clot degrading proteins and activation of fibrinolysis as appreciated by Starzl in…
2021 American Transplant Congress
Outcomes of Kidney Transplant Recipients With Sickle Cell Disease: An Analysis of the 2000-2019 UNOS/OPTN Database
N. Leeaphorn¹, C. Thongprayoon², C. Jadlowiec³, A. Chewcharat⁴, P. Hansrivijit⁵, S. Katari¹, P. Vaitla⁶, L. Cummings¹, M. Cooper⁷, W. Cheungpasitporn²
¹Saint Luke's Health System, Kansas City, MO, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic, Phoenix, AZ, ⁴Mount Auburn Hospital, Cambridge, MA, ⁵University of Pittsburgh Medical Center Pinnacle, Harrisburg, PA, ⁶University of Mississippi Medical Center, Jackson, MS, ⁷Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: Lower patient survival has been observed in sickle cell disease (SCD) patients who go on to receive a kidney transplant. This study aimed to…
2021 American Transplant Congress
Medical Costs in the Year Following Kidney Transplantation: Relationships with Renal Function and Graft Failure
M. Cooper¹, M. A. Schnitzler², C. Nilubol¹, W. Wang³, X. Zhu³, J. Wu³, R. J. Nordyke⁴
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Saint Louis University, St. Louis, MO, ³Genesis Research, Hoboken, NJ, ⁴Angion Biomedica, San Francisco, CA
*Purpose: We describe relationships between total medical costs in the first year following kidney transplant with overall renal function as measured by: 1) estimated glomerular…
2021 American Transplant Congress
Time-averaged Oxygen Saturation During Donor Agonal Phase is Associated with Post-transplant Hepatic Graft Survival
K. C. Eddinger¹, E. M. Sonnenberg¹, A. Kayastha², N. Mahmud³, D. E. Schaubel², P. L. Abt¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, ³Gastroenterology, Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Livers harvested from donors after cardiac death (DCD) are subjected to a period of relative warm ischemia during the agonal phase. There have been…
2021 American Transplant Congress
Liver Dysfunction Following Lung Transplantation
E. J. Hyzny¹, E. G. Chan¹, J. P. Ryan¹, T. Harano¹, M. R. Morrell², P. G. Sanchez¹
¹Cardiothoracic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: To describe the incidence and risk factors for postoperative hepatic dysfunction (POHD) following lung transplantation (LT) and long-term outcomes for these patients.*Methods: We performed…

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