Articles tagged "Graft failure"

2015 American Transplant Congress
External Validation of Clinical Prediction Models of Patient and Graft Survival in a Canadian Cohort of Kidney Transplant Recipients
S. Singh,^1,2 D. Naimark,^1,2,3 J. Victor,² J. Kim.^1,2,4,5
¹Division of Nephrology, Department of Medicine, University of Toronto, Toronto, ON, Canada; ²Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; ³Division of Nephrology, Sunnybrook Health Sciences Center, Toronto, ON, Canada; ⁴Division of Nephrology and the Kidney Transplant Program, University Health Network, Toronto, ON, Canada; ⁵Division of Nephrology and the Renal Transplant Program, St. Michael's Hospital, Toronto, ON, Canada.
Background: Several clinical prediction models (CPM) of patient and graft survival in kidney transplant recipients have been developed as tools to assist physicians in identifying…
2015 American Transplant Congress
Increased Late Graft Loss in Kidney Recipients With Serum Sickness Disease Following Anti-Thymocyte Globulin Induction: Relation With an Anti-Neu5Gc Response
A. Salama,^1,2 G. Couvrat-Desvergnes,¹ M. Lorent,^1,3 G. Evanno,¹ L. Le Berre,¹ P. Hruba,⁴ P. Vesely,⁵ P. Guerif,¹ A. Nicot,¹ J.-M. Bach,⁶ Y. Foucher,^1,3 S. Brouard,¹ S. Castagnet,⁷ O. Viklicky,⁴ M. Giral,¹ J. Harb,¹ S. Jean-Paul.¹
¹INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; ²Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; ³EA 4275 SPHERE, Biostatistics, Clinical Research and Pharmaco-Epidemiology, Nantes, France; ⁴Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; ⁵Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; ⁶IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; ⁷EFS Pays de la Loire, Nantes, France.
Anti-thymocyte globulins (ATG) are rabbit IgGs against human T cells widely used as induction treatment of kidney recipients. ATG can induce immune-complex diseases including Serum…
2015 American Transplant Congress
Single Nucleotide Polymorphisms (SNPs) Associated With Acute Rejection in European American Kidney Transplant Recipients: A Genome Wide Association Study (GWAS)
A. Israni,¹ C. Dorr,¹ M. Miller,² D. Schladt,¹ K. Sanghavi,³ A. Muthusamy,¹ R. Remmel,³ W. Guan,⁴ B. Wu,⁴ W. Oetting,³ P. Jacobson,³ A. Matas,⁵ For DeKAF Genomics & GEN03 Investigators.¹
¹Medicine, MMRF, Hennepin County Medical Center, Minneapolis, MN; ²Psychology, University of MN, Minneapolis, MN; ³Pharmacy, University of MN, Minneapolis, MN; ⁴Biostatistics, University of MN, Minneapolis, MN; ⁵Surgery, University of MN, Minneapolis, MN.
Purpose: Acute rejection (AR) is associated with increased risk of allograft loss. Therefore, we conducted a GWAS to determine SNPs associated with AR in a…
2015 American Transplant Congress
Outcomes of Live Kidney Donors Who Develop End Stage Renal Disease
A. Muzaale, A. Massie, L. Kucirka, D. Segev.
Johns Hopkins, Baltimore.
Kidney donors can develop ESRD after donation, but the outcomes of those who do remain poorly characterized.Methods: Using USRDS and SRTR data, we compared access…
2015 American Transplant Congress
Comparison of Markers of Inflammation Between Dialysis Patients With and Without Failed Kidney Allograft
R. Villca-Gonzales, R. Vazquez-Apodaca, D. Hernandez-Ramirez, L. Llorente-Peters, J. Alberu, L. Morales-Buenrostro.
Nephrology and Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, DF, Mexico.
BACKGROUND: The rates of morbidity and mortality in patients with a failed kidney transplant are higher than dialysis patients who had never been transplanted. The…
2015 American Transplant Congress
Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment
M. Duerr,¹ K. Daemen,² J. Keil,² K. Budde,¹ C. Falk.²
¹Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany; ²Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany.
In renal transplant patients (pts), B- and plasma cells (PC) are crucial for donor-specific HLA antibody (DSA) formation. The underlying mechanisms, which lead to B…