ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft failure"

  • 2015 American Transplant Congress

    Inflammation in Regions of Tubular Atrophy (IATR) Predicts Adverse Graft Outcome in Patients With Late Graft Dysfunction: A Multicenter Study

    J. Grande,1 R. Leduc,3 A. Matas.2

    1Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN; 2Surgery, University of Minnesota, Minneapolis, MN; 3Biostatistics, University of Minnesota, Minneapolis, MN.

    Purpose: Inflammation in regions of tubular atrophy (IATR) is a risk factor for late graft loss. However, IATR is associated with inflammation in non-atrophic regions…
  • 2015 American Transplant Congress

    Respiratory Infections Following Lung Transplantation Leads to De Novo Development of Antibodies to Both Donor HLA and Lung Associated Self-Antigens and Increases the Risk for Bronchiolitis Obliterans Syndrome

    K. George,1 M. Gunasekaran,1 M. Sharma,1 F. Zhou,1 A. Limaye,3 R. Hachem,2 T. Mohanakumar.1

    1Surgery, Washington Univ, St. Louis, MO; 2Medicine, Washington Univ, St. Louis, MO; 3Medicine, Univ Washington, Seattle, WA.

    Background: It is accepted that lower respiratory tract infections (LRI) post lung transplantation (LTx) are a risk factor for the development of Bronchiolitis Obliterans Syndrome…
  • 2015 American Transplant Congress

    External Validation of Clinical Prediction Models of Patient and Graft Survival in a Canadian Cohort of Kidney Transplant Recipients

    S. Singh,1,2 D. Naimark,1,2,3 J. Victor,2 J. Kim.1,2,4,5

    1Division of Nephrology, Department of Medicine, University of Toronto, Toronto, ON, Canada; 2Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; 3Division of Nephrology, Sunnybrook Health Sciences Center, Toronto, ON, Canada; 4Division of Nephrology and the Kidney Transplant Program, University Health Network, Toronto, ON, Canada; 5Division of Nephrology and the Renal Transplant Program, St. Michael's Hospital, Toronto, ON, Canada.

    Background: Several clinical prediction models (CPM) of patient and graft survival in kidney transplant recipients have been developed as tools to assist physicians in identifying…
  • 2015 American Transplant Congress

    Increased Late Graft Loss in Kidney Recipients With Serum Sickness Disease Following Anti-Thymocyte Globulin Induction: Relation With an Anti-Neu5Gc Response

    A. Salama,1,2 G. Couvrat-Desvergnes,1 M. Lorent,1,3 G. Evanno,1 L. Le Berre,1 P. Hruba,4 P. Vesely,5 P. Guerif,1 A. Nicot,1 J.-M. Bach,6 Y. Foucher,1,3 S. Brouard,1 S. Castagnet,7 O. Viklicky,4 M. Giral,1 J. Harb,1 S. Jean-Paul.1

    1INSERM UMR 1064, ITUN, CHU de Nantes, Nantes University, Nantes, France; 2Société d'Accélération du Transfert de Technologies Ouest Valorisation, Rennes, France; 3EA 4275 SPHERE, Biostatistics, Clinical Research and Pharmaco-Epidemiology, Nantes, France; 4Transplant Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; 5Central European Institute of Technology, Brno University of Technology, Brno, Czech Republic; 6IECM, EA4644 University/ONIRIS USC1383 INRA, ONIRIS, Nantes, France; 7EFS Pays de la Loire, Nantes, France.

    Anti-thymocyte globulins (ATG) are rabbit IgGs against human T cells widely used as induction treatment of kidney recipients. ATG can induce immune-complex diseases including Serum…
  • 2015 American Transplant Congress

    Single Nucleotide Polymorphisms (SNPs) Associated With Acute Rejection in European American Kidney Transplant Recipients: A Genome Wide Association Study (GWAS)

    A. Israni,1 C. Dorr,1 M. Miller,2 D. Schladt,1 K. Sanghavi,3 A. Muthusamy,1 R. Remmel,3 W. Guan,4 B. Wu,4 W. Oetting,3 P. Jacobson,3 A. Matas,5 For DeKAF Genomics & GEN03 Investigators.1

    1Medicine, MMRF, Hennepin County Medical Center, Minneapolis, MN; 2Psychology, University of MN, Minneapolis, MN; 3Pharmacy, University of MN, Minneapolis, MN; 4Biostatistics, University of MN, Minneapolis, MN; 5Surgery, University of MN, Minneapolis, MN.

    Purpose: Acute rejection (AR) is associated with increased risk of allograft loss. Therefore, we conducted a GWAS to determine SNPs associated with AR in a…
  • 2015 American Transplant Congress

    Outcomes of Live Kidney Donors Who Develop End Stage Renal Disease

    A. Muzaale, A. Massie, L. Kucirka, D. Segev.

    Johns Hopkins, Baltimore.

    Kidney donors can develop ESRD after donation, but the outcomes of those who do remain poorly characterized.Methods: Using USRDS and SRTR data, we compared access…
  • 2015 American Transplant Congress

    Comparison of Markers of Inflammation Between Dialysis Patients With and Without Failed Kidney Allograft

    R. Villca-Gonzales, R. Vazquez-Apodaca, D. Hernandez-Ramirez, L. Llorente-Peters, J. Alberu, L. Morales-Buenrostro.

    Nephrology and Transplantation, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, DF, Mexico.

    BACKGROUND: The rates of morbidity and mortality in patients with a failed kidney transplant are higher than dialysis patients who had never been transplanted. The…
  • 2015 American Transplant Congress

    Antibody-Mediated Rejection Is Associated With Higher Serum Levels of CXCL13 and CCL21 in Renal Transplant Patients and Altered By Bortezomib/Rituximab Treatment

    M. Duerr,1 K. Daemen,2 J. Keil,2 K. Budde,1 C. Falk.2

    1Nephrology, Charité Universitätsmedizin Berlin, Berlin, Germany; 2Institute of Transplant Immunology, IFB-Tx, MHH, Hannover, Germany.

    In renal transplant patients (pts), B- and plasma cells (PC) are crucial for donor-specific HLA antibody (DSA) formation. The underlying mechanisms, which lead to B…
  • 2015 American Transplant Congress

    Cognate Events in Antibody- Vs. T Cell-Mediated Rejection: A Molecular Perspective

    M. Parkes,1 P. Halloran,1 L. Hidalgo.2

    1Department of Medicine, University of Alberta, Edmonton, AB, Canada; 2Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.

    AIM: The cognate event in antibody-mediated rejection (ABMR) is NK cell FcR engagement; T cell mediated rejection (TCMR) uses TCR engagement. Understanding the molecular changes…
  • 2015 American Transplant Congress

    100 Protocol Renal Allograft Biopsies at 10 Years: First Look at the Tacrolimus Era

    M. Stegall,1 W. Park,1 F. Cosio,2 L. Cornell.3

    1Transplant Surgery, Mayo Clinic, Rochester, MN; 2Medicine, Mayo Clinic, Rochester, MN; 3Laboratory Medicine, Mayo Clinic, Rochester, MN.

    This study examined late renal allograft injury in the Tacrolimus era in 10-yr protocol biopsies (Bx).Methods One hundred 10-yr protocol allograft bx were assessed using…
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