Articles tagged "Graft failure"

2016 American Transplant Congress
Share35 Liver Allocation Is Associated with Increased Early Graft Failure Rate.
T. Wong,¹ N. Koizumi,² J. Ortiz.³
¹Maricopa Medical Center, Phoenix, AZ; ²George Mason University, Arlington, VA; ³University of Toledo, Toledo, OH.
Background: The implementation of Share35 liver allocation policy in June 2013 facilitated the increase in number of transplanted livers with less organ discards. Early analysis…
2016 American Transplant Congress
Natural History of Response to Wounding in Human Kidney Transplants.
K. Famulski,¹ J. Venner,^2,1 J. Reeve,¹ P. Halloran.¹
¹University of Alberta, Edmonton, AB, Canada; ²University of Queensland, Brisbane, Queensland, Australia.
In both primary kidney diseases and kidney transplants, the extent of fibrosis is a key indicator of stage, progression, and prognosis. Much debate focuses, however,…
2016 American Transplant Congress
A 30% Decrease in Post-kidney Transplant Estimated Glomerular Filtration Rate (eGFR) from 6 Mo-2 Y Is a Surrogate for 5 Y eGFR: Results from Clinical Trials in Organ Transplantation-(CTOT)-17.
G. Faddoul,¹ G. Nadkarni,¹ D. Hricik,² P. Heeger,¹ CTOT17 Investigators.
¹Medicine and Recanati Miller Transplant Institute, Icahn School of Medicine, NY, NY; ²Medicine, Case Medical Center, Cleveland, OH.
Predicting long-term kidney allograft outcomes using early clinical/biomarker data could guide individualized therapy. Emerging evidence in progressive native kidney disease indicates >30% decrease in eGFR…
2016 American Transplant Congress
Treatment of Late Antibody-Mediated Rejection: Observations from Clinical Practice.
G. Einecke,¹ J. Bräsen,² A. Schwarz,¹ H. Haller,¹ F. Njau.¹
¹Nephrology, Medical School of Hannover, Hannover, Germany; ²Pathology, Medical School of Hannover, Hannover, Germany.
Antibody-mediated rejection (AMR) is a major cause of late renal allograft failure. The benefit of treatment of chronic ABMR is unknown. Currently there is no…
2016 American Transplant Congress
Using Predictive Modeling to Manage Cardiovascular Risk and Improve Kidney Transplant Outcomes.
W. Moran, J. Zhang, Z. Su, D. Taber, P. Mauldin, T. Srinivas.
MUSC, Charleston.
Objective: We aimed to improve post-kidney transplant (tx) outcomes through predictive analytics and natural language processing (NLP) integrated into the electronic health record (EHR). The…
2016 American Transplant Congress
Impact of Machine Perfusion on Long-Term Kidney Transplant Outcomes.
S. Sandal,^1,2 X. Luo,² A. Massie,² M. Cantarovich,¹ D. Segev.²
¹MUHC, Montreal, Canada; ²JHU, Baltimore.
Machine perfusion (MP) has been shown to decrease DGF rates in kidney transplant (KT) recipients when compared with static cold storage (CS). However, there is…
2016 American Transplant Congress
Sequential and Long-Term Protocol Biopsy Is Useful for the Detection of Subclinical Lesions of Clinical Interest in Kidney Allografts.
M. Miura,¹ H. Higashiyama,¹ T. Tsuji,² Y. Fukasawa.²
¹Department of Urology and Renal Transplantation Surgery, Sapporo Hokuyu Hospital, Sapporo, Japan; ²Department of Pathology, Sapporo City General Hospital, Sapporo, Japan.
Objectives: Detection of subclinical lesions is important to overcome the obstacles to improve long-term graft survival after kidney transplantation. The aim of this study was…
2016 American Transplant Congress
Development of an Integrated Transplant Data Mart for Customized Data Reporting.
R. Patzer, K. Little, J. Kirsch, J. Weaver, A. Adams.
Emory University, Atlanta.
Background: Transplant centers have a large amount of clinical data from multiple data sources that are utilized for quality tracking of clinical outcomes, regulatory reports,…
2016 American Transplant Congress
Probability, Risk Factors, and Long-Term Outcomes of Biliary Complications After Hepatic Artery Thrombosis in Adult Liver Transplant Recipients: 20 Years Experience from a Single Center.
M. Fujiki, K. Hashimoto, T. Diago, C. Quintini, F. Aucejo, D. Kelly, B. Eghtesad, J. Fung, C. Miller.
General Surgery, Cleveland Clinic, Cleveland, OH.
Hepatic artery thrombosis (HAT) after liver transplantation (LT) is a devastating complication associated with ischemic biliary cholangiopathy (IBC) that can occur even after successful revascularization.…
2015 American Transplant Congress
Cognate Events in Antibody- Vs. T Cell-Mediated Rejection: A Molecular Perspective
M. Parkes,¹ P. Halloran,¹ L. Hidalgo.²
¹Department of Medicine, University of Alberta, Edmonton, AB, Canada; ²Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada.
AIM: The cognate event in antibody-mediated rejection (ABMR) is NK cell FcR engagement; T cell mediated rejection (TCMR) uses TCR engagement. Understanding the molecular changes…