Articles tagged "Graft failure"

2022 American Transplant Congress
Patient Outcomes After Heart and Double Lung Transplant from a Single High-Volume Center
R. P. Brumer¹, A. Goodarzi², R. Chihara¹
¹Department of Surgery, Houston Methodist Hospital, Houston, TX, ²J.C. Walter Jr. Transplant Center, Houston Methodist Hospital, Houston, TX
*Purpose: Combined heart and double-lung transplant (OHT/DLT) is a relatively uncommon procedure, and patient outcomes after undergoing OHT/DLT are therefore not as well understood as…
2022 American Transplant Congress
Novel Peripheral Molecular Markers Predict Premature Graft Loss: Lessons Learned from Operational Tolerance Assessment
O. Viklicky¹, A. Le², J. Klema², E. Girmanova³, P. Mrazova³, A. Massart⁴, D. Abramowitz⁴, M. Abramowicz⁴, P. Hruba³
¹Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Computer Science, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic, ³Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ⁴Universite Libre de Bruxelles (ULB), Brussel, Belgium
*Purpose: TOMOGRAM, European multicenter study, recently identified new cohort of kidney transplant recipients (KTR) with operational tolerance (OT) with the aim to identify new transcriptomic…
2022 American Transplant Congress
Poor Prognosis of Proliferative Glomerulonephritis with Monoclonal IgG Deposits in Renal Allografts: A Retrospective Multicenter Study from China
Q. Wu¹, D. Liang¹, X. Ni¹, T. Song², X. Wu³, M. Zhang¹, J. Chen¹, D. Cheng¹, W. Jiqiu¹
¹National Clinical Research Center of Kidney Diseases, Jinling Hospital,Nanjing University Jinling School of Medicine, Nanjing, China, ²Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China, ³Department of Urology, Henan Provincial People's Hospital; Zhengzhou University People's Hospital, Zhengzhou, China
*Purpose: To analyze the clinicopathological characteristics, treatment efficacy and prognosis of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) in renal allografts from multi-centers in China.*Methods:…
2022 American Transplant Congress
Prescription Opioid Use May be More Detrimental to Younger Kidney Transplant Recipients: A Machine Learning Approach
J. Kim¹, S. Bae¹, J. Ahn¹, K. Lentine², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins, Baltimore, MD, ²Saint Louis University, St. Louis, MO
*Purpose: Prescription opioid use requires special attention in kidney transplant (KT) recipients considering that it increases the risk of death and graft loss. However, the…
2022 American Transplant Congress
Is Donor Hepatitis C Virus Infection Status Associated with Early Post-Kidney Transplant Failure in the Era of Direct-Acting Antiviral Medications?
S. Sutcliffe¹, S. Chang¹, D. Stewart², M. Ji³, K. Lentine⁴, G. Gupta⁵, T. Alhamad⁶
¹Washington University School of Medicine, Saint Louis, MO, ²United Network for Organ Sharing, Richmond, VA, ³Washington University in St. Louis School of Medicine, Saint Louis, MO, ⁴Saint Louis University School of Medicine, Saint Louis, MO, ⁵Virginia Commonwealth University School of Medicine, Richmond, VA, ⁶Washington University School of Medicine at St. Louis, Saint Louis, MO
*Purpose: To determine the influence of donor hepatitis C virus (HCV) infection status on early kidney transplant (KT) failure in HCV negative recipients in the…
2022 American Transplant Congress
Donor Factors Do Not Discriminate Living Donor Kidney Transplant Outcomes and Should Not Be Used to Promote the Use of Compatible Pairs in Kidney Paired Donation Programs
G. Irish¹, D. Chang², S. Chadban¹, N. Boudville¹, S. Campbell¹, J. Kanellis¹, L. McMichael², E. Sharples³, M. Kadatz², J. Gill², P. Clayton¹
¹ANZDATA, Adelaide, Australia, ²Providence Health Research Institute, Transplant Research, Vancouver, BC, Canada, ³Oxford University Trust Hospital, Oxford, United Kingdom
*Purpose: Enrolment of ABO blood group and HLA incompatible pairs in kidney paired donation programs improves matching potential. The benefit for compatible pairs, however, is…
2022 American Transplant Congress
Assessing Proportion of Days Covered (PDC) of Mycophenolate (MCP) Prescriptions in Post Kidney Transplant (KT) Recipients as a Predictor of Clinical Outcomes
K. Sandlin¹, T. Sam¹, N. Wilson¹, A. Yango², B. Fischbach³, A. Dao¹
¹Pharmacy, Baylor University Medical Center, Dallas, TX, ²Baylor All Saints Medical Center, Dallas Nephrology Associates, Fort Worth, TX, ³Baylor University Medical Center, Dallas Nephrology Associates, Dallas, TX
*Purpose: Nonadherence to medications following KT is a risk factor for adverse outcomes. PDC is an objective measure of adherence obtained through retail prescription records…
2022 American Transplant Congress
Association Between Increased Overweight at First Year After Kidney Transplantation and Long-Term Kidney Graft Outcome
H. Choi¹, K. Huh², K. B. Seok³
¹Yonsei University College of Medicine, Seoul, Korea, Republic of, ²Department of Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of
*Purpose: The obesity is increasing in chronic kidney disease patients and associated with poor renal outcome. The role of inflammation within the adipose tissue in…
2022 American Transplant Congress
Pancreatic Islets Engineered with Thrombomodulin Show Enhanced Engraftment in an Intraportal Transplantation Model by Mitigating Instant Blood-Mediated Inflammatory Reactions
A. Turan¹, L. Zhang², M. Tarique², V. Ulker², E. Yolcu³, H. Shirwan³
¹Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO, ²Department of Child Health, University of Missouri at Columbia, Columbia, MO, ³Child Health and Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO
*Purpose: IBMIR is a major culprit of early islet loss post-transplant. Thrombomodulin (TM) is an anti-coagulant and cofactor of activated Protein C (APC) that perpetuates…
2022 American Transplant Congress
Recipient Race Modifies the Association Between Obesity and Long Term Graft Outcomes After Renal Transplantation
F. Jarrar¹, K. Tennankore², A. J. Vinson³
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada, ³Nova Scotia Health Authority Division of Nephrology, Departm, Halifax, NS, Canada
*Purpose: Both donor and recipient obesity are associated with adverse outcomes after transplant. Whether obesity, defined using body mass index (BMI), has different implications on…