Articles tagged "Graft failure"

2022 American Transplant Congress
Association Between CT Measurements of Body Composition Before Liver Transplantation and Post-Transplantation Outcomes
Y. Liu¹, O. Shafaat¹, K. Jackson¹, J. Motter¹, B. Boyarsky¹, M. Latif¹, F. Yuan¹, E. King¹, A. Zaheer¹, R. Summers², D. Segev¹, M. McAdams-DeMarco¹, C. Weiss¹
¹Johns Hopkins University, Baltimore, MD, ²NIH Clinical Center, Bethesda, MD
*Purpose: Various methods exist for measuring body composition using computed tomography (CT) scans; however, it is unclear which components best predict post-liver transplantation (LT) outcomes.…
2022 American Transplant Congress
Predictors of Delayed Kidney Graft Function Following Combined Liver and Kidney Transplantation
P. Vincenzi¹, J. Gaynor², R. Vianna³, G. Ciancio³
¹General Surgery, Ospedali Riuniti Marche Nord, Pesaro, Italy, ²General Surgery, Miami Transplant Institute, Miami, FL, ³Transplant Surgery, Miami Transplant Institute, Miami, FL
*Purpose: Combined liver and kidney transplantation (CLKT) improves the survival in liver transplant recipients with renal dysfunction. However, kidney DGF (kDGF) still represents a common…
2022 American Transplant Congress
Real-Time Application of Deep Learning in Diagnosis of Graft Fibrosis After Liver Transplantation Using Longitudinal Data
A. Azhie¹, D. Sharma², P. Sheth¹, W. Xu³, M. Bhat¹
¹Ajmera Transplant Program, University Health Network, Toronto, ON, Canada, ²Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, ³Biostatistics Division, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
*Purpose: Graft fibrosis develops insidiously in liver transplant recipients and is associated with worse survival. Early detection of fibrosis is essential to avoid further progression…
2022 American Transplant Congress
Predicting Long Term Kidney-Allograft Failure: Machine Learning vs Traditional Statistical Models
A. Truchot¹, M. Raynaud¹, c. lefaucheur², O. Aubert¹, A. Loupy¹
¹Paris Transplant Group, Paris, France, ²Hôpital Saint-Louis, Paris, France
*Purpose: Prognostic models have been developed in organ transplant over the past years using traditional statistical models. However, whether these are outperformed by machine learning…
2022 American Transplant Congress
Infections Following Rejection Therapies in Solid Organ Transplant Recipients
S. Gupta¹, J. Gea-Banacloche², H. Me³, D. M. Chascsa⁴, H. R. Vikram², R. Yaman¹, L. Kodali³
¹Internal Medicine, Mayo Clinic, Scottsdale, AZ, ²Infectious Diseases, Mayo Clinic, Phoenix, AZ, ³Transplant Nephrology, Mayo Clinic, Phoenix, AZ, ⁴Hepatology, Mayo Clinic, Phoenix, AZ
*Purpose: Infections are known complications of solid-organ transplant. They are most prevalent in the first 12 months after transplant when immunosuppression is at its peak.…
2022 American Transplant Congress
Implementing Clinical Decision Support Tools for Immunosuppressant Drug-Drug Interactions to Prevent Graft Failure
A. Yishak¹, S. Ledan², S. Mukherjee³, C. Chen², A. Ayoola², T. Kim², A. Olenik², K. Mullican², A. Henje², N. Lorence², L. Beckman²
¹MAPMG, Mc Lean, VA, ²Kaiser Permanente, Silver Spring, MD, ³MAPMG, Rockville, MA
*Purpose: Immunosuppressant drug-drug interactions can result in immunosuppressant toxicity or subtherapeutic levels causing rejection. If not identified and managed appropriately, these interactions may result in…
2022 American Transplant Congress
Development of a Radiomics-Based Model to Predict Graft Fibrosis in Liver Transplant Recipients: A Pilot Study
F. Qazi Arisar¹, E. Salinas-Miranda², H. Ale Ali², K. Lajkosz³, C. Chen¹, A. Azhie¹, G. M. Healy², D. Deniffel², M. A. Haider², M. Bhat¹
¹Ajmera Transplant Program, University Health Network, Toronto, ON, Canada, ²Lunenfeld Tanenbaum Research Institute, Toronto, ON, Canada, ³Department of Biostatistics, University Health Network, Toronto, ON, Canada
*Purpose: Recurrent fibrosis complicates 40% of Liver transplants (LT), compromising long-term survival. We evaluated the ability of a model combining radiomic features on CT scans…
2022 American Transplant Congress
Mitochondrial Dysfunction and Alloimmunity in Chronic Lung Transplant Rejection
M. Cano¹, D. Zhou², C. Chen³, K. Pugh⁴, D. Byers¹, D. Kreisel⁵, R. Hachem¹, A. Gelman⁵
¹Pulmonary and Critical Care, Washington University, Saint Louis, MO, ²Surgery, Washington University, Saint Louis, MO, ³Pulmonary and Critical Care, UT Southwestern Medical Center, Dallas, TX, ⁴Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, ⁵Surgery and Immunology and Pathology, Washington University, Saint Louis, MO
*Purpose: Bronchiolitis obliterans syndrome (BOS) remains a major cause of death after lung transplantation. Unfortunately, we lack effective treatments for BOS as the mechanisms by…
2022 American Transplant Congress
Post-Kidney Transplant Body Mass Index Trajectories Are Associated with Graft Loss and Mortality
Y. Liu¹, V. Bendersky¹, X. Chen¹, M. Harhay², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins University, Baltimore, MD, ²Drexel University, Philadelphia, PA
*Purpose: Early post-kidney transplantation (KT) changes in physiology, medications, and health stressors likely impact body mass index (BMI). Hence, we sought to estimate trajectories of…
2022 American Transplant Congress
Identification of a Human B Cell State with Allogeneic Antigen Cross-Presenting Potential
U. Bhatia, E. C. Guinan
Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA
*Purpose: B cells are known to play a significant role in allograft tolerance or rejection, largely determined by production of cytokines and antibodies that suppress…