Articles tagged "Graft failure"

2018 American Transplant Congress
Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis
R. Ang, N. Chun, A. Ting, P. Heeger.
Immunology Institute, Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York, NY.
We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…
2018 American Transplant Congress
Title: Donor-Derived Cell Free DNA Predicts Development of Clinically Significant Changes in Donor Specific Antibody Following Kidney Transplant
A. Brubaker,¹ D. Stoltz,¹ M. Grskovic,² R. Woodward,² A. Gallo.¹
¹Department of Surgery, Division of Abdominal Transplantation, Stanford University, Stanford, CA; ²CareDx, Brisbane, CA.
Background: Recently, high immunologic risk patients comprise a significant percentage of the total adult renal transplants performed yearly. Surveillance management of these patients and interpretation…
2018 American Transplant Congress
Standard Induction Immunosuppression Interferes with the Role of Vascularized Bone Marrow in Vascularized Composite Allograft Protection
N. Shockcor, E. Buckingham, W. Hassanein, A. Nam, S. Bartlett, R. Barth.
Department of Surgery, University of Maryland School of Medicine, Baltimore, MD.
Purpose: Clinical induction therapies have been demonstrated to interfere with the development of immunologic tolerance in experimental models. Vascularized bone marrow (VBM) has been demonstrated…
2018 American Transplant Congress
Everolimus and the Risk of Graft Loss or Death in Kidney Transplant Recipients: A Trial-Based Linkage Study
T. Ying,^1,2 G. Wong, W. Lim, G. Russ, H. Pilmore, J. Kanellis, D. Goodman, P. Trevillian, S. Campbell, M. Suranyi, M. Mathew, R. Faull, R. Masterson, R. Walker, P. O'Connell, S. Chadban.^1,2
¹Renal Medicine, Royal Prince Alfred Hospital, Camperdown, Australia; ²Kidney Node, Charles Perkins Centre, University of Sydney, Sydney, Australia.
Background: The use of mTORIs may be associated with a reduction of cancer incidence after kidney transplantation (KT) and improved graft function compared with calcineurin-inhibitor…
2018 American Transplant Congress
Risk Factors and Sequelae of Post-KT Delirium
M. McAdams DeMarco, A. Mountford, F. Warsame, R. Berkowitz, H. Ying, C. Haugen, D. Brennan, D. Segev.
JHU, Baltimore.
Background: Delirium is the acute decline in cognitive function following a noxious insult like surgery. Previous studies in other surgical settings have identified frailty and…
2018 American Transplant Congress
Identifying the Specific Causes of Kidney Allograft Loss: A Population Based Study
C. Loheac, O. Aubert, D. VIglietti, N. Kamar, M. Delahousse, C. Lefaucheur, A. Loupy.
Paris Translational Research Center for Organ Transplantation, Paris, France.
Understanding the specific causes of kidney allograft loss is mandatory to improve the longevity of kidney allografts. However, the current literature is limited by the…
2018 American Transplant Congress
Comparison of Bortezomib in Addition to Rituximab Based Treatment of Acute Antibody Mediated Rejection in Kidney Transplantation
A. Mattiazzi,^1,2 J. Pagan,^1,2 A. Arunachalam,¹ I. De la Cruz Alcantara,¹ J. Revollo,² A. Centeno,² A. Valdes,^1,2 G. Guerra.^1,2
¹Nephrology & Hypertension, University of Miami, Miami, FL; ²Miami Transplant Institute, Jackson Memorial Hospital, Miami, FL.
Purpose:The optimal treatment strategy of acute antibody mediated rejection (AMR) in renal allograft recipients remains undefined. The aim of our study was to compare the…
2018 American Transplant Congress
New Sensitive Markers for Early Diagnosis of Transplant Glomerulopathy in Kidney Recipients
Y-.C. Xu-Dubois, K. Louis, C. Jouanneau, D. Buob, N. Ouali, A. Hertig, E. Rondeau.
U1155, INSERM, Paris, France; Urgences Néphrologiques & Transplantation Rénale, APHP, Hôpital Tenon, Paris, France; Santé Publique, APHP, Hôpital Tenon, Paris, France; Sorbonne Universités, UPMC Université Paris 6, Paris, France.
Chronic antibody mediated rejection (ABMR) with Transplant glomerulopathy (TG) remains a major contributor of renal graft loss in the long term. New sensitive markers are…
2018 American Transplant Congress
ABO‐incompatible Deceased Donor Liver Transplantation
X. Luo, C. Haugen, A. Thomas, J. Garonzik-Wang, D. Segev.
Johns Hopkins, Baltimore, MD.
ABO-incompatible liver transplantation (ILT) has increased over the past decade despite reports suggesting that adult ILT recipient have worse outcomes than ABO-compatible liver transplant (CLT)…
2018 American Transplant Congress
Pump Resistive Index Values and Not Preimplantation Kidney Biopsy Predict Kidney Allograft Survival
J. Liu,¹ A. Blumfield,¹ M. Trivedi,¹ N. Mishra,¹ O. Mohammed,^1,2 J. Lin,³ M. Ajaimy,^1,2 J. Graham,^1,2 J. Rocca,^1,2 E. Akalin,^1,2 S. Greenstein.^1,2
¹Albert Einstein College of Medicine, Bronx, NY; ²Department of Surgery, Montefiore Medical Center, Bronx, NY; ³Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
AimTo investigate the relationship between histological findings of preimplantation kidney biopsies and pump resistive index (RI) values during machine preservation and subsequent allograft survival.MethodsWe retrospectively…