ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft failure"

  • 2022 American Transplant Congress

    Association Between Increased Overweight at First Year After Kidney Transplantation and Long-Term Kidney Graft Outcome

    H. Choi1, K. Huh2, K. B. Seok3

    1Yonsei University College of Medicine, Seoul, Korea, Republic of, 2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

    *Purpose: The obesity is increasing in chronic kidney disease patients and associated with poor renal outcome. The role of inflammation within the adipose tissue in…
  • 2022 American Transplant Congress

    Pancreatic Islets Engineered with Thrombomodulin Show Enhanced Engraftment in an Intraportal Transplantation Model by Mitigating Instant Blood-Mediated Inflammatory Reactions

    A. Turan1, L. Zhang2, M. Tarique2, V. Ulker2, E. Yolcu3, H. Shirwan3

    1Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO, 2Department of Child Health, University of Missouri at Columbia, Columbia, MO, 3Child Health and Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO

    *Purpose: IBMIR is a major culprit of early islet loss post-transplant. Thrombomodulin (TM) is an anti-coagulant and cofactor of activated Protein C (APC) that perpetuates…
  • 2022 American Transplant Congress

    Recipient Race Modifies the Association Between Obesity and Long Term Graft Outcomes After Renal Transplantation

    F. Jarrar1, K. Tennankore2, A. J. Vinson3

    1Dalhousie University, Halifax, NS, Canada, 2Nova Scotia Health Authority, Halifax, NS, Canada, 3Nova Scotia Health Authority Division of Nephrology, Departm, Halifax, NS, Canada

    *Purpose: Both donor and recipient obesity are associated with adverse outcomes after transplant. Whether obesity, defined using body mass index (BMI), has different implications on…
  • 2022 American Transplant Congress

    HLA-DQ Mismatches Are More Likely to Be Listed as Unacceptable Antigens After Renal Graft Failure in African American Recipients as Compared to Other Racial/Ethnic Groups

    D. Isaacson1, M. W. Gmeiner2, V. Kosmoliaptsis3, J. D. Schold4, A. R. Tambur1

    1Northwestern University, Chicago, IL, 2London School of Economics, London, United Kingdom, 3Cambridge University, Cambridge, United Kingdom, 4Cleveland Clinic, Cleveland, OH

    *Purpose: Growing evidence suggests that donor-recipient mismatches at the HLA-DQ locus are the most immunogenic and pathogenic, evidenced by generation of DQ donor-specific antibodies (DSA).…
  • 2022 American Transplant Congress

    Impact of HLA Matching on Graft Survival in Kidney Transplant Recipients

    J. Miller1, N. Salkowski1, B. Thompson1, R. Kandaswamy2, P. Stock3, A. Israni1

    1Scientific Registry of Transplant Recipients, Minneapolis, MN, 2Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, 3Department of Surgery, University of California San Francisco, San Francisco, CA

    *Purpose: This study aims to estimate the association of HLA matching at the A, B, DR, and DQ loci with posttransplant graft failure and patient…
  • 2022 American Transplant Congress

    Interventional Radiology Procedures for Complications of Orthotopic Liver Retransplantation: A 22-year Single Center Experience

    A. F. Sayed Ahmed1, B. B. Toskich1, S. A. Mao2

    1Interventional Radiology, Mayo Clinic, Jacksonville, FL, 2Transplant Surgery, Mayo Clinic, Jacksonville, FL

    *Purpose: Liver retransplantation (re-OLT) represents a high risk, resource intense, operation for recipients with failed allografts. We review our single center 22-year experience with re-OLT…
  • 2022 American Transplant Congress

    Autologous Mesenchymal Stem Cells for Treatment of Chronic Antibody-Mediated Kidney Graft Rejection: Report of the First Phase I/II Clinical Case Series

    Ž. Večerić-Haler1, M. Sever2, N. Kojc3, G. Mlinšek1, M. Oblak1, P. Halloran4, A. Aleš Rigler1, J. Buturović Ponikvar1, M. Arnol5

    1Nephrology, UMC Ljubljans, Ljubljana, Slovenia, 2Haematology, UMC Ljubljans, Ljubljana, Slovenia, 3Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana,, Ljubljana, Slovenia, 4Division of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 5University Medical Centre Ljubljana, Ljubljana, Slovenia

    *Purpose: The aim of this study is to evaluate the safety and efficacy of autologous mesenchymal stem cellc (MSCs) in combination with standard of care…
  • 2022 American Transplant Congress

    Comparison of Outcomes in High Donation After Circulatory Death Liver Transplantation Usage Centers in the Acuity Circles Era

    L. Chau1, A. Mohamed2, T. Kitajima1, K. Collins3, M. Rizzari1, A. Yoshida4, M. Abouljoud3, S. Nagai1

    1Henry Ford Hospital, Detroit, MI, 2Department of Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI, 3Henry Ford Transplant Institute, Detroit, MI, 4Henry Ford Hospital, Grosse Pointe, MI

    *Purpose: The recent acuity circles (AC) liver allocation policy has increased rates of donation after circulatory death (DCD) liver transplantation. We hypothesize transplant centers with…
  • 2022 American Transplant Congress

    Fibrinolysis Shutdown Subtype of Early Allograft Dysfunction Represents the Predominant Cohort of Patients with Graft Failure Following Liver Transplantation

    H. B. Moore1, T. L. Nydam2, M. Adams3, T. Ferrell1, I. Rodriguez4, D. Yoeli1, R. Choudhury1, J. Pomposelli1, E. A. Pomfret1

    1University of Colorado, Aurora, CO, 2Univeristy of Colorado, Aurora, CO, 3Childrens Hospital Colorado, Aurora, CO, 4University of Colorado Anschutz Medical Campus, Aurora, CO

    *Purpose: Early allograft dysfunction (EAD) is associated with an increased rate of graft failure in liver transplantation (LT), but a mechanism remains unclear. Recent experience…
  • 2022 American Transplant Congress

    A Novel Mismatch That Modulates the Innate Alloresponse Risk Stratifies Renal Transplant Patients

    H. Dai, K. Abou Daya, M. Oberbarnscheidt, R. Mehta, C. Macedo, D. Metes, Q. Xu, A. Zeevi, P. Randhawa, F. Lakkis, A. Cherukuri

    Thomas E. Starzl Transplantation Institute, UPMC, Pittsburgh, PA

    *Purpose: Donor polymorphism in the gene encoding signal regulatory protein alpha (SIRPα) is a key modulator of the recipient’s innate alloresponse. Here, we investigated the…
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