Articles tagged "Graft failure"

2022 American Transplant Congress
Do Clinical & Pathologic Signs of Rejection Develop Following Transplantation of Tissue Containing Non-Autologous Mitochondria in an Autologous Nuclear Cloned Host?
S. Jacob¹, M. L. Baack², A. Savinov³, P. J. Wettstein⁴
¹Cardiothoracic Surgery and transplantation, Mayo Clinic, Jacksonville, FL, ²Division of Neonatology, University of South Dakota – Sanford School of Medicine, Sioux Falls, SD, ³Sanford Research, University of South Dakota School of Medicine, Sioux Falls, SD, ⁴Departments of Surgery and Immunology, Mayo Clinic, Rochester, MN
*Purpose: Recent studies have yielded conflicting results on the capacity of oocyte-encoded mtDNA polymorphisms to stimulate rejection . Therefore, there are still questions as to…
2022 American Transplant Congress
Clinical Significances Of Anti-collagen Type I And Type Iii Antibodies In Antibody-mediated Rejection
S. Park¹, S. Yang¹, K. Moon¹, J. Ha¹, Y. Kim¹, E. Song¹, H. Lee²
¹Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: It is important to determine the clinical significance of non-human leukocyte antigen (HLA) antibodies and their association with antibody-mediated rejection (ABMR) of kidney allografts.*Methods:…
2022 American Transplant Congress
Protein and Transcriptomic Differences Between High and Low Neointimal Arteries in Human Cardiac Allograft Vasculopathy Rejected Grafts
J. Nevarez-Mejia¹, H. C. Pickering¹, R. A. Sosa¹, R. P. Lau¹, G. A. Fishbein¹, W. M. Baldwin III², R. L. Fairchild², E. F. Reed¹
¹University of California, Los Angeles, Los Angeles, CA, ²Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: Cardiac allograft vasculopathy (CAV) is the leading cause of graft failure and mortality following heart transplantation. Donor specific antibodies (DSA) contribute to CAV progression…
2022 American Transplant Congress
Transplant Graft TMA Injury Post COVID-19 Vaccination
O. Sogbein, A. Rizvi, M. Mujtaba, S. Hussain
Internal Medicine, Division of Nephrology, University of Texas Medical Branch, Galveston, TX
*Purpose: Vaccination against SARS-CoV-2 is essential. Complicating this effort are reports of a suboptimal response to the SARS-CoV-2 spike protein in patients on immunosuppressive medications…
2022 American Transplant Congress
Validation of a Prediction System for Risk of Allograft Loss (iBOX) in Pediatric Kidney Transplant Recipients
J. Hogan¹, G. Divard², R. Garro³, O. Boyer⁴, M. Seifert⁵, J. Smith⁶, B. Toenshoff⁷, K. Twombley⁸, B. Warady⁹, P. Weng¹⁰, R. Zaar¹¹, R. Patzer¹², A. Loupy²
¹Pediatric Nephrology, Robert Debré Hospital, APHP, Paris, France, ²Paris Transplant Group, INSERM, Paris, France, ³Pediatric Nephrology, Children Healthcare of Atlanta, Atlanta, GA, ⁴Pediatric Nephrology, Necker Hospital, Paris, France, ⁵UAB School of Medicine, Birmingham, AL, ⁶Pediatric Nephrology, Seattle Children, Seattle, WA, ⁷University Children's Hospital, Heidelberg, Germany, ⁸Medical University of South Carolina, Charleston, SC, ⁹Childrens Mercy Hospital, Kansas City, MO, ¹⁰Pediatric Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ¹¹Pediatric Nephrology, Le Bonheur Children's Hospital, Memphis, TN, ¹²Emory Transplant Center, Emory University, Atlanta, GA
*Purpose: Kidney allograft loss is a common cause of end-stage renal disease but accurate prediction models of kidney allograft loss are lacking in children. The…
2022 American Transplant Congress
Clinical Significance of the Living Kidney Donor Profile Index in Living Kidney Donors for Predicting of Post-Transplant Outcome: Korean Organ Transplantation Registry
J. Kim¹, D. Kim¹, S. Yoon¹, S. Kang¹, J. Kim¹, H. Hwang¹, K. Jeong¹, H. Ko², C. Jung³, D. Kim⁴, Y. Kim⁵, J. Yang⁶, C. Ahn⁷
¹Department of Nephrology, Kyung Hee University hospital, Seoul, Korea, Republic of, ²Department of Surgery, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ³Department of Transplantation and Vascular Surgery, Korea University Anam Hospital, Seoul, Korea, Republic of, ⁴Department of Surgery, Yonsei University Wonju College of Medicine, Wonju Severance Christian Hospital, Wonju, Korea, Republic of, ⁵Department of Internal Medicine, Inje University Busan Paik Hospital, Busan, Korea, Republic of, ⁶Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, ⁷Department of Nephrology, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: According to recent reports, a risk index for living donor kidney transplantation (LDKT) such as the Kidney donor profile index (KDPI), a non-invasive method…
2022 American Transplant Congress
The Natural History of De Novo DSA After Kidney Transplantation
C. López del Moral¹, N. Lachmann², S. Hergovits², D. Stauch², A. Akifova³, M. Naik³, B. Osmanodja³, D. Schmidt³, K. Budde³
¹Nephrology department-IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Institute for Transfusion Medicine, HLA-Laboratory, Charité - Universitätsmedizin, Berlin, Germany, ³Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Germany
*Purpose: De novo donor-specific antibodies(dnDSA) are key in the diagnosis of antibody-mediated rejection(ABMR) and are related to graft loss(GL). Luminex® provides semi-quantitative information with the…
2022 American Transplant Congress
Association Between CT Measurements of Body Composition Before Kidney Transplantation and Post-Transplantation Outcomes
Y. Liu, O. Shafaat, X. Chen, C. Weiss, D. Segev, M. McAdams-DeMarco
Johns Hopkins University, Baltimore, MD
*Purpose: Body composition has been found to be associated with the risks of post-kidney transplantation (KT) outcomes. However, it is unclear which pre-KT computed tomography…
2022 American Transplant Congress
The Role of Donor Sex in Females Undergoing Repeat Kidney Transplant: Does Prior Donor Sex Matter?
S. Craig¹, K. Tennankore², A. J. Vinson²
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Female recipients of male donor kidneys are at increased risk for graft failure compared with all other donor-recipient sex pairings. The presumed mechanism relates…
2022 American Transplant Congress
Digital Spatial Profiling of Kidney Allograft Biopsies with Chronic Allograft Dysfunction in African American Transplant Recipients
C. R. Dorr¹, S. A. Elmer¹, B. Wu², B. Guo², J. Czyzyk², G. Crary³, G. Onyeaghala¹, W. Oetting², P. Jacobson², R. B. Mannon⁴, G. Agarwal⁵, J. Maltzman⁶, A. Matas², A. Israni³
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Hennepin County Medical Center, Minneapolis, MN, ⁴Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Stanford University, Palo Alto, CA
*Purpose: Understanding tissue heterogeneity is important to identify the molecular and cellular mechanisms of kidney allograft loss in African American (AA) transplant recipients. Our aim…