ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft failure"

  • 2019 American Transplant Congress

    Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Chronic Active Antibody-Mediated Rejection

    D. Kumar1, M. Raynaud2, P. Halloran3, A. Loupy2, J. Chang3, J. Reeve3, I. Yakubu1, S. Bobba1, L. Kamal1, M. Levy1, C. Bhati1, P. Kimball1, A. King1, G. Gupta1

    1Virginia Commonwealth University, Richmond, VA, 2Paris Transplant Group, Paris, France, 3Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada

    *Purpose: Chronic active antibody mediated rejection (cABMR) is a major cause of long-term kidney transplant (KT) loss. Current therapies have unclear efficacy and significant side…
  • 2019 American Transplant Congress

    Conceptual Extension of SNP Based Abundance Profiling to Infer Donor Derived Cell-Free DNA Fraction as an Indication of Organ Rejection

    R. Sinha, K. Mickey, J. Grantham, M. Wissel, M. Altrich, S. Kleiboeker

    R&D, Viracor-Eurofins, Lee's Summit, MO

    *Purpose: Rejection is a major post-transplant complication for organ transplant recipients. Biopsy remains the standard to diagnose rejection, but other non-invasive methods, such as transcript…
  • 2019 American Transplant Congress

    Delayed Graft Function as a Survival Prognostic Factor in Elderly Recipients of Kidney Transplantation

    G. J. Piñeiro, E. Guillen, P. Ventura, J. V. Torregrosa, R. Gelpi, I. Revuelta, F. Cofan, E. De Sousa, D. Cucchiari, J. Ugalde, F. Oppenheimer, F. Diekmann, N. Esforzado

    Nephrology and Kidney Transplantation, Hospital Clínic of Barcelona, Barcelona, Spain

    *Purpose: Kidney transplantation (KT) provides advantages in terms of survival compared with dialysis. However, in elderly recipients, despite a better long-term survival, a high mortality…
  • 2019 American Transplant Congress

    Calcineurin Inhibitors and Long-Term Outcomes of Kidney Transplantation from Thai Transplant Registry

    S. Udomkarnjananun, N. Townamchai, Y. Avihingsanon, K. Praditpornsilpa

    Chulalongkorn University, Bangkok, Thailand

    *Purpose: Calcineurin inhibitors (CNIs) have became the primary immunosuppressive medications (IS) for kidney transplantation (KT) in the current era. However, the long-term outcomes of KT…
  • 2019 American Transplant Congress

    International Multicenter Study Evaluating Clinical Outcomes Associated with Acute Antibody-Mediated Rejection

    S. Corman1, I. Hirji2, E. Brouwer2, S. H. Park1, C. Macahilig3, A. Vergani2, T. Bo2, P. Wolthoff3, P. Keown4

    1Pharmerit International, Bethesda, MD, 2Shire, Cambridge, MA, 3Medical Data Analytics, Parsippany, NJ, 4University of British Columbia, Vancouver, BC, Canada

    *Purpose: Evaluating factors that impact clinical outcomes of patients with acute antibody-mediated rejection (aAMR) may help manage and improve outcomes following kidney transplant. The objective…
  • 2019 American Transplant Congress

    High Numbers of Differentiated CD8+CD28– T Cells Are Associated with a Substantially Lowered Risk for Late Rejection and Graft Loss after Kidney Transplantation

    M. G. Betjes, A. Langerak, M. Klepper, N. Litjens

    Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands

    *Purpose: Recipients of a kidney transplant have a prematurely aged T-cell system. This is reflected in lowered thymic output, reduced telomere length and more highly…
  • 2019 American Transplant Congress

    The Combination of 3-Month Estimated Glomerular Filtration Rate and Proteinuria is a Valuable Tool for Evaluating Long-Term Kidney Graft Survival

    C. Mottola1, N. Girerd2, K. Duarte3, A. Aarnink4, M. Kessler5, L. Frimat6, S. Girerd6

    1Nephrology and Kidney Transplant Unit, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, 2Clinical Investigation Center 1433, INSERM U1116, INI-CRCT, F-CRIN, Lorraine University, Vandoeuvre-lès-Nancy, France, 3Clinical Investigation Center 1433, INSERM 1116, INI-CRCT, F-CRIN, Lorraine Univeristy, Vandoeuvre-lès-Nancy, France, 4Laboratoire d’Histocompatibilité, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, 5Nephrology and kidney transplant unit, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, 6Nephrology and kidney transplant unit, INI-CRCT, F-CRIN, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France

    *Purpose: Estimated glomerular filtration rate (eGFR) measured at 1 year is the usual outcome used to predict the long-term graft survival in the field of…
  • 2019 American Transplant Congress

    Clinical Impact of Spontaenous Portosystemic Shunts on the Short Term Outcome of Liver Transplantation

    E. A. Rodriguez1, R. M. Perez2, N. Zhang3, E. S. Lim3, C. R. Miller4, M. A. Schwartz2, A. J. McGirr4, A. Srinivasan5, W. R. Hewitt5, A. C. Silva4, J. Rakela1, H. E. Vargas1

    1Transplant Hepatology, Mayo Clinic Arizona, Phoenix, AZ, 2Mayo Clinic School of Medicine, Mayo Clinic Arizona, Phoenix, AZ, 3Division of Health Sciences Research, Mayo Clinic Arizona, Phoenix, AZ, 4Radiology, Mayo Clinic Arizona, Phoenix, AZ, 5Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ

    *Purpose: The aim of our study was to compare Liver Transplant (LT) candidates with and without spontaneous portosystemic shunts (SPSS) and assess their impact on…
  • 2019 American Transplant Congress

    Risk Factors for Sensitization in the Failing Allograft: A Multi-Center Experience

    M. Lubetzky1, O. Mohammed2, N. Hauser1, R. Friedlander1, V. Sharma1, A. Colovai2, T. Muthukumar1, J. Lee1, E. Akalin2, D. Dadhania1

    1Division of Nephrology, Weil Cornell, New York, NY, 2Division of Nephrology, Montefiore Medical Center, New York, NY

    *Purpose: Sensitization is frequent after an allograft fails and makes re-transplant difficult for many patients.*Methods: We performed a cross-sectional chart review of patients who were…
  • 2019 American Transplant Congress

    Impact of Granulocyte Colony Stimulating Factor on Clinical Outcomes in Kidney Transplant Recipients with Neutropenia

    H. Yao1, A. Alam2, R. Sapir-Pichhadze2, D. D’Arienzo3, D. Baran2, S. Sandal2, M. Cantarovich2

    1Critical Care Medicine, McGill University Health Center, Montreal, QC, Canada, 2Nephrology and Multi-Organ Transplant Program, McGill University Health Center, Montreal, QC, Canada, 3Medicine, McGill University Health Center, Montreal, QC, Canada

    *Purpose: Neutropenia, defined as an absolute neutrophil count (ANC)
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