Articles tagged "Graft failure"

2019 American Transplant Congress
Patterns of Rejection in Murine, Porcine, and Human Vascularized Composite Allografts Based on Clinical, Histologic, and Immunohistochemical Analysis
M. J. Grzelak, J. W. Etra, F. A. Chang, G. J. Furtmüller, A. R. Ahmadi, F. Nägele, Y. Guo, K. Kambarashvili, A. Jain, S. A. Beck, C. F. Brayton, I. B. Sander, W. A. Lee, G. Brandacher
Plastic and Reconstructive Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: The side effects of chronic immunossupression limit the more extensive use of Vascularized Composite Allotransplantation (VCA), and because reliable pre-clinical animal models will be…
2019 American Transplant Congress
Pre-Transplant Transcriptomic Signature in Peripheral Blood Predicts Early Acute Rejection after Kidney Transplant
W. Zhang¹, Z. Yi¹, C. Wei¹, K. Keung², Z. Sun¹, C. Xi¹, C. Woytovich¹, S. Farouk¹, L. Gallon³, M. Menon¹, C. Magee⁴, N. Najafian⁴, M. Samaniego⁵, A. Djamali⁶, S. Alexander², I. Rosales⁷, R. Smith⁷, P. O'Connell², R. Colvin⁷, P. Cravedi¹, B. Murphy¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²The University of Sydney, Sydney, Australia, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Henry Ford Hospital, Detroit, MI, ⁶University of Wisconsin, Madison, WI, ⁷Massachusetts General Hospital, Boston, MA
*Purpose: Early development of acute rejection after kidney transplantation is associated with diminished long-term graft survival. Predicting early acute rejection (EAR) at the time of…
2019 American Transplant Congress
Pushing the Limits: A Large Multicentric Case-Control Study Evaluating the Impact of Kidney Transplants from Expanded Criteria Donors after Controlled Circulatory Death the Limits: A Large Multicentric Case-Control Study Evaluating the Impact of Kidney Transplants from Expanded Criteria Donors after Controlled Circulatory Death
N. Toapanta¹, R. Alvarez², G. Lluís³, C. Facundo³, F. Diekmann⁴, I. Revuelta⁴, M. Meneghini², F. Moreso¹, O. Bestard²
¹Kidney Transplantation Unit, Vall d'Hebron University Hospital, Barcelona, Spain, ²Kidney Transplantation Unit, Bellvitge University Hospital- IDIBELL, L'Hospitalet de Llobregat. Barcelona, Spain, ³Kidney Transplantation Unit, Puigvert University Hospital, Barcelona, Spain, ⁴Kidney Transplantation Unit, Clinic University Hospital, Barcelona, Spain
*Purpose: Controlled donation after circulatory death (cDCD) has allowed to significantly increase the deceased donors pool. However, while excellent previous reports have been shown using…
2019 American Transplant Congress
Clinical Importance of the Updated Oxford Classification in Allograft IgA Nephropathy
S. Park¹, H. Go², C. Baek², J. Jeong¹, Y. Kim¹, Y. Kim¹, Y. Kim², J. Lee³, S. Min¹, J. Ha¹, E. Song¹, Y. Kim¹, S. Park², K. Moon¹, H. Lee¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Asan Medical Center, Seoul, Korea, Republic of, ³Seoul National University Hospital, Boramae Medical Center, Seoul, Korea, Republic of
*Purpose: An additional investigation on the clinical significance of the updated Oxford classification in allograft IgA nephropathy (IgAN) is warranted.*Methods: We performed a retrospective cohort…
2019 American Transplant Congress
Silent Allograft Fibrosis in 10-Year Post-Transplantation Histology of Pediatric Liver Transplantation: Is It Really Silent?
S. Lee, S. Lee, J. Rhu, Y. Chung, S. Kim, K. Lee, S. Lee, J. Kim, G. Choi , J. Park, S. Kim, J. Joh
Transplantation, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: This study is designed to analyze factors related to long-term allograft fibrosis in clinically stable pediatric liver transplantation patients.*Methods: Pediatric patients who underwent liver…
2019 American Transplant Congress
Belatacept Monotherapy in Kidney Transplant Recipients with Failed Allografts Reduces Humoral Sensitization in a Single Center Randomized Controlled Trial
I. R. Badell, R. Elbein, R. A. Bray, H. M. Gebel, A. B. Adams, C. P. Larsen
Emory University School of Medicine, Atlanta, GA
*Purpose: Kidney transplant recipients with failed allografts suffer from high rates of humoral sensitization. Immunosuppression (IS) strategies are highly variable in these patients with many…
2019 American Transplant Congress
A Single Measurement of Torque Teno Virus Helps to Predict Mortality in Renal Transplant Patients
E. Gore¹, C. van Leer¹, A. de Joode², I. Nolte³, J. Westra⁴, A. Gomes Neto², H. G. Niesters¹, S. J. Bakker²
¹Department of Medical Microbiology, University Medical Centre Groningen, Groningen, Netherlands, ²Department of Nephrology, University Medical Centre Groningen, Groningen, Netherlands, ³Department of Epidemiology, University Medical Centre Groningen, Groningen, Netherlands, ⁴Department of Immunology, University Medical Centre Groningen, Groningen, Netherlands
*Purpose: Multiple studies have used longitudinal Torque Teno Virus (TTV) measurements to assess the immune status after transplantation. Longitudinal measurements generally show a TTV load…
2019 American Transplant Congress
The Implications of Donor Proteinuria in Deceased Donor Kidney Transplantation
A. Vinson, T. Keough-Ryan, K. West, K. Tennankore
Dalhousie University, Halifax, NS, Canada
*Purpose: The implications of pre-terminal donor urinalysis findings on post-transplant kidney graft survival has not been previously explored. An abnormal donor urinalysis may reflect donor…
2019 American Transplant Congress
Association Of Clinical Characteristics With Rate Of Kidney Transplant Function Decline In The 2 Years Prior To Allograft Loss
L. A. Binari, P. E. Thorne, J. L. Morse, T. G. Stewart, R. C. Forbes, K. Rabb, L. Lipworth, K. Abdel-Kader, B. P. Concepcion
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The rate of kidney transplant function decline prior to allograft loss has not been well characterized. Identifying demographic and clinical characteristics associated with slow…
2019 American Transplant Congress
Impact of Size Mismatch on Long-Term Graft Survival after Orthotopic Liver Transplantation
K. Kamrani¹, A. Okoh², A. Mathur³, L. Brown⁴
¹Dept. of Surgery, Monmouth Medical Center, Long Branch, NJ, ²Dept. of Medicine, Newark Beth Israel Medical Center, Newark, NJ, ³Div. of Transplant Surgery, Mayo Clinic, Scottsdale, AZ, ⁴Div. of Liver Transplant Surgery, University Hospital, Newark, NJ
*Purpose: The aim of the current study is to investigate recent trends in mismatched organs utilized for orthotopic liver transplantation (OLT) and examine the impact…