Articles tagged "Graft failure"

2019 American Transplant Congress
International Multicenter Study Evaluating Clinical Outcomes Associated with Acute Antibody-Mediated Rejection
S. Corman¹, I. Hirji², E. Brouwer², S. H. Park¹, C. Macahilig³, A. Vergani², T. Bo², P. Wolthoff³, P. Keown⁴
¹Pharmerit International, Bethesda, MD, ²Shire, Cambridge, MA, ³Medical Data Analytics, Parsippany, NJ, ⁴University of British Columbia, Vancouver, BC, Canada
*Purpose: Evaluating factors that impact clinical outcomes of patients with acute antibody-mediated rejection (aAMR) may help manage and improve outcomes following kidney transplant. The objective…
2019 American Transplant Congress
High Numbers of Differentiated CD8⁺CD28^– T Cells Are Associated with a Substantially Lowered Risk for Late Rejection and Graft Loss after Kidney Transplantation
M. G. Betjes, A. Langerak, M. Klepper, N. Litjens
Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands
*Purpose: Recipients of a kidney transplant have a prematurely aged T-cell system. This is reflected in lowered thymic output, reduced telomere length and more highly…
2019 American Transplant Congress
The Combination of 3-Month Estimated Glomerular Filtration Rate and Proteinuria is a Valuable Tool for Evaluating Long-Term Kidney Graft Survival
C. Mottola¹, N. Girerd², K. Duarte³, A. Aarnink⁴, M. Kessler⁵, L. Frimat⁶, S. Girerd⁶
¹Nephrology and Kidney Transplant Unit, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, ²Clinical Investigation Center 1433, INSERM U1116, INI-CRCT, F-CRIN, Lorraine University, Vandoeuvre-lès-Nancy, France, ³Clinical Investigation Center 1433, INSERM 1116, INI-CRCT, F-CRIN, Lorraine Univeristy, Vandoeuvre-lès-Nancy, France, ⁴Laboratoire d’Histocompatibilité, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, ⁵Nephrology and kidney transplant unit, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France, ⁶Nephrology and kidney transplant unit, INI-CRCT, F-CRIN, University Hospital of Nancy, Vandoeuvre-lès-Nancy, France
*Purpose: Estimated glomerular filtration rate (eGFR) measured at 1 year is the usual outcome used to predict the long-term graft survival in the field of…
2019 American Transplant Congress
Clinical Impact of Spontaenous Portosystemic Shunts on the Short Term Outcome of Liver Transplantation
E. A. Rodriguez¹, R. M. Perez², N. Zhang³, E. S. Lim³, C. R. Miller⁴, M. A. Schwartz², A. J. McGirr⁴, A. Srinivasan⁵, W. R. Hewitt⁵, A. C. Silva⁴, J. Rakela¹, H. E. Vargas¹
¹Transplant Hepatology, Mayo Clinic Arizona, Phoenix, AZ, ²Mayo Clinic School of Medicine, Mayo Clinic Arizona, Phoenix, AZ, ³Division of Health Sciences Research, Mayo Clinic Arizona, Phoenix, AZ, ⁴Radiology, Mayo Clinic Arizona, Phoenix, AZ, ⁵Transplant Surgery, Mayo Clinic Arizona, Phoenix, AZ
*Purpose: The aim of our study was to compare Liver Transplant (LT) candidates with and without spontaneous portosystemic shunts (SPSS) and assess their impact on…
2019 American Transplant Congress
Risk Factors for Sensitization in the Failing Allograft: A Multi-Center Experience
M. Lubetzky¹, O. Mohammed², N. Hauser¹, R. Friedlander¹, V. Sharma¹, A. Colovai², T. Muthukumar¹, J. Lee¹, E. Akalin², D. Dadhania¹
¹Division of Nephrology, Weil Cornell, New York, NY, ²Division of Nephrology, Montefiore Medical Center, New York, NY
*Purpose: Sensitization is frequent after an allograft fails and makes re-transplant difficult for many patients.*Methods: We performed a cross-sectional chart review of patients who were…
2019 American Transplant Congress
Impact of Granulocyte Colony Stimulating Factor on Clinical Outcomes in Kidney Transplant Recipients with Neutropenia
H. Yao¹, A. Alam², R. Sapir-Pichhadze², D. D’Arienzo³, D. Baran², S. Sandal², M. Cantarovich²
¹Critical Care Medicine, McGill University Health Center, Montreal, QC, Canada, ²Nephrology and Multi-Organ Transplant Program, McGill University Health Center, Montreal, QC, Canada, ³Medicine, McGill University Health Center, Montreal, QC, Canada
*Purpose: Neutropenia, defined as an absolute neutrophil count (ANC)
2019 American Transplant Congress
Biomarker Candidate Discovery for Kidney Allograft Monitoring via Urinary Exosome Proteome Analysis
J. Kim¹, Y. Wee¹, M. Choi¹, H. Jung¹, J. Choi¹, H. Kwon¹, J. Jung¹, Y. Ko¹, D. Kim¹, K. Kim², Y. Cho³, H. Go³, Y. Kim¹, D. Han¹, S. Shin¹
¹Department of Surgery, Asan Medical Center, Seoul, Korea, Republic of, ²Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ³Department of Pathology, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: There is a need for the development of noninvasive molecular biomarkers with high reliability and predictive power for early diagnosis and monitoring of any…
2019 American Transplant Congress
Urine Uromodulin Associates with Deceased Donor Acute Kidney Injury and Allograft Failure
S. G. Mansour¹, I. Hall², P. Reese³, T. Ashkar⁴, Y. Jia⁴, H. Thiessen-Philbrook⁴, M. Doshi⁵, C. R. Parikh⁴
¹Yale, New Haven, CT, ²University of Utah, Salt Lake City, UT, ³Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ⁴Johns Hopkins University, Baltimore, MD, ⁵University of Michigan, Ann Arbor, MI
*Purpose: Produced exclusively by renal epithelial cells of the thick ascending limb, Uromodulin (UMOD, also known as Tamm-Horsfall protein) is the major component of hyaline…
2019 American Transplant Congress
Nodular Regenerative Hyperplasia after Liver Transplant – It is All in the Presentation
A. K. Chen¹, S. Yamaguchi², C. Praglin², E. Agudelo², F. K. Yao², S. M. Syed², G. R. Roll²
¹University of California, San Francisco - Fresno, Fresno, CA, ²University of California, San Francisco, San Francisco, CA
*Purpose: There is a paucity of data on nodular regenerative hyperplasia (NRH) after liver transplant (LT). We report the largest existing case series with extensive…
2019 American Transplant Congress
Effects of Co-Morbidities on Kidney Transplantation Outcome in South Korea: A Nationwide-Population Based Study
M. Yu¹, S. Park², J. Moon², J. Jeong², J. Kim², Y. Kim², K. Han³, Y. Kim², H. Lee²
¹Hanyang University Guri Hospital, Guri, Korea, Republic of, ²Seoul National University Hospital, Seoul, Korea, Republic of, ³College of Medicine, Catholic University, Seoul, Korea, Republic of
*Purpose: Kidney transplantation (KT) has become the most effective treatment for end stage renal disease. Improvement of general medical care as well as immunosuppressive agents…