Articles tagged "Graft failure"

2020 American Transplant Congress
Eplet Mismatch Not Correlated with Antibody Mediated Rejection or Allograft Loss Among Kidney Transplant Recipients with De Novo Donor Specific Antibody
A. Basu¹, W. Jiqiu², A. Bentall², M. Gandhi², B. Dukek², N. Henderson², C. Schinstock²
¹Emory Healthcare, Atlanta, GA, ²Mayo Clinic, Rochester, MN
*Purpose: Eplet mismatches are associated with development of de novo DSA (dnDSA) in kidney transplant recipients. However, it remains unclear how the degree of eplet…
2020 American Transplant Congress
Antibiotic Pretreatment Alleviates Liver Transplant Damage by Modulating the Composition of Commensal Microbiota
K. J. Dery, S. Kageyama, H. Hirao, K. Kadono, H. Kojima, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The human intestinal microbiome contains more than 100 trillion commensal microorganisms, exceeding the number of cells in the human body by 10-fold. Although recent…
2020 American Transplant Congress
The Accuracy of the ICD-10 Diagnostic Codes for Kidney Transplant Rejection and Failure
D. Massicotte-Azarniouch¹, M. Sood², D. Fergusson³, M. Chassé⁴, A. Tinmouth⁵, G. Knoll²
¹Medicine, University of Ottawa, Ottawa Hospital, Ottawa, ON, Canada, ²Medicine, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ³Clinical Epidemiology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁴Medicine, University of Montreal, Ottawa, ON, Canada, ⁵Hematology, University of Ottawa, Ottawa Hospital Research Institute, Ottawa, ON, Canada
*Purpose: Clinical research requires that diagnostic codes captured from routinely collected health administrative data accurately identify individuals with a disease. In this study, we examined…
2020 American Transplant Congress
Transplant and Cardiovascular Outcomes in Renal Transplant Recipients with Different Pre-Transplant Cardiovascular Risk
G. Hsu¹, T. M. Sparkes¹, B. N. Reed², S. E. Gale¹, B. R. Ravichandran¹
¹University of Maryland Medical Center, Baltimore, MD, ²University of Maryland School of Pharmacy, Baltimore, MD
*Purpose: Renal transplant patients have higher cardiovascular (CV) risk compared to their peers. Pre-transplant CV risk factors may be amplified post-transplant, but little is known…
2020 American Transplant Congress
Sequential Protocol Biopsies Post-Liver Transplant from Donors with Moderate Macrosteatosis: What Happens to the Fat?
K. Croome, D. Livingston, C. Taner, R. Nakhleh
Mayo Clinic Jacksonville, Jacksonville, FL
*Purpose: The number of steatotic deceased donor livers encountered has continued to rise as a result of the obesity epidemic. Little is known about the…
2020 American Transplant Congress
Evaluating the Effect of HCV Status on the KDPI in the Era of DAA Therapy
J. Husson¹, S. Curreli², B. Ravichandran³, E. Wilson⁴
¹Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, ²Institute of Human Virology, Baltimore, MD, ³University of Maryland Medical Center, University of Maryland School of Pharmacy, Baltimore, MD, ⁴Institue of Human Virology, University of Maryland School of Medicine, Baltimore, MD
*Purpose: The association between KDPI and kidney graft outcomes is limited in the era of DAA therapy.*Methods: We analyzed adult renal transplants, at the University…
2020 American Transplant Congress
Changes in Gut Microbiota and Acute Rejection after Kidney Transplantation
H. Cho¹, J. Kim², H. Kim², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, H. Lee²
¹Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc. Seoul National University, Seoul, Korea, Republic of, ⁵Department of Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of, ⁶Department of Life Science, Multidisciplinary Genome Institute, Hallym University, Chuncheon, Korea, Republic of
*Purpose: Kidney transplantation (KT) is the best treatment for end-stage renal disease. Although rejection is a normal immune response of the body to a foreign…
2020 American Transplant Congress
Late Onset Primary Graft Dysfunction after Lung Transplantation Correlates with Transplant Arteriosclerosis in a Humanized Mouse Model
M. Franz¹, T. Siemeni¹, A. Knöfel¹, W. Sommer¹, M. Avsar¹, F. Ius¹, I. Tudorache¹, C. Kühn¹, C. S. Falk², G. Warnecke¹, A. Haverich¹
¹Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ²IFB-Tx, Hannover Medical School, Hannover, Germany
*Purpose: Primary Graft dysfunction (PGD) is one of the most important causes of early mortality after lung transplantation. We investigated the correlation between the incidence…
2020 American Transplant Congress
Incidence, Risk Factors, and Kidney Transplant Outcomes Associated with Post-Transplant Diabetes Mellitus
R. F. Malik¹, Y. Jia¹, S. G. Mansour², I. E. Hall², M. D. Doshi², P. P. Reese², P. Singh², M. N. Harhay², F. L. Weng², H. Thiessen Philbrook¹, B. Schröppel², T. Muthukumar², J. S. Bromberg², E. Akalin², S. Mohan², C. R. Parikh¹
¹Johns Hopkins University, Baltimore, MD, ²DDS Consortium, Baltimore, MD
*Purpose: Post-Transplant Diabetes Mellitus (PTDM) is a common complication after kidney transplant (KT). Most prior studies are single-center with short follow-up and inconsistent outcome ascertainment.…
2020 American Transplant Congress
Using Artificial Intelligence Tools for Identification of High Risk Transplant Recipients for Focused Management
M. A. Schnitzler¹, C. Dagli², C. Canfield², N. Dzebisashvili³, C. Varma¹, D. Axelrod⁴, K. Lentine¹, R. Ouseph¹, H. Randall¹
¹Saint Louis University, St. Louis, MO, ²Missouri S&T, Rolla, MO, ³CareDx, Brisbane, CA, ⁴University of Iowa, Iowa City, IA
*Purpose: Resources for post-transplant patient monitoring are limited. Statistical stratification can facilitate focused attention on highest risk patients. We developed a monitoring tool for graft…