Articles tagged "Graft failure"

2020 American Transplant Congress
Belatacept Conversion: Are Patients BENEFIT-ing
R. Crew, S. Mohan, S. S. Patel
Columbia University Irving Medical Center, New York, NY
*Purpose: Belatacept is increasingly used in renal transplant recipients experiencing adverse effects from calcineurin inhibitors(CNI) despite limited medium- and long- term data on safety and…
2020 American Transplant Congress
Quantifiable Loss of Insulin Secretory Granules in Delayed Endocrine Pancreas Graft Function in Comparison to Controls
C. B. Drachenberg¹, J. C. Papadimitriou¹, J. R. Scalea², A. Haririan³, R. Ugarte³, S. Niederhaus², J. Bromberg²
¹Pathology, University of Maryland, Baltimore, MD, ²Surgery, University of Maryland, Baltimore, MD, ³Medicine, University of Maryland, Baltimore, MD
*Purpose: Approximately 1/3 of pancreas transplant fail to gain glycemic control in the first days/weeks posttransplantation, requiring exogenous insulin administration. Delayed endocrine pancreas graft function…
2020 American Transplant Congress
Kidney Graft Survival by the Teaching Status of a Transplant Center (2008-2019)
K. Maroney, Z. Wang, K. Ross, J. Hogan, R. Patzer
Emory University, Atlanta, GA
*Purpose: Graft survival is an important metric in which transplant centers are graded, yet center-level variation in kidney graft survival still exist after accounting for…
2020 American Transplant Congress
Assessing the Complex Causes of Kidney Allograft Loss
E. Van Loon¹, A. Senev¹, E. Lerut², M. Coemans¹, D. Kuypers¹, M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²KU Leuven, Leuven, Belgium
*Purpose: Although graft loss is a primary endpoint in many studies in kidney transplantation and a broad spectrum of risk factors has been identified, the…
2020 American Transplant Congress
Potential Cost-Savings Associated with ANG-3777 for the Treatment of Delayed Graft Function in Kidney Transplantation
M. Cooper¹, T. Mayne², T. Kauf³, M. Gargano³, K. Freemyer³
¹Medstar Georgetown Transplant Institute, Washington, DC, ²Angion Biomedica Corp, San Francisco, CA, ³Genesis Research, Hoboken, NJ
*Purpose: We created a medical cost offset model based upon the results of a Phase 2, double-blind, randomized controlled trial of ANG-3777, a hepatocyte growth…
2020 American Transplant Congress
Clinical Outcomes Associated with Long-Term Exposure to Airborne Particulate Pollution in Kidney Transplant Recipients
Y. Kim¹, J. Lee²
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of
*Purpose: We aimed to evaluate the relationship of 10-μm particulate matter (PM10) with the risk of graft failure, mortality, and decline of graft function in…
2020 American Transplant Congress
One Year of COIIN Outcomes: Did Cohorts A and B Maintain Graft Survival?
J. Foutz, R. J. Carrico, K. Sisaithong, H. Tosoc-Haskell, D. Klassen
United Network for Organ Sharing, Richmond, VA
*Purpose: The Collaborative Innovation and Improvement Network (COIIN) was a 3-year OPTN project aimed at increasing the utilization of kidneys with a kidney donor profile…
2020 American Transplant Congress
Association of Kidney Allograft Fibrosis-Associated Proteins with Chronic Lung Allograft Dysfunction
S. Farkona¹, G. Berra², Z. Mohammed-Ali¹, P. Ly², L. Levy², B. Renaud-Picard², G. Zehong², T. Daigneault², S. Juvet², C. McEvoy¹, S. Clotet-Freixas¹, T. Martinu², A. Konvalinka¹
¹Nephrology, Toronto General Hospital Research Institute and Multi-Organ Transplant, University Health Network, Toronto, ON, Canada, ²Lung Transplantation, Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) remains the leading cause of long-term mortality after lung transplant. Non invasive biomarkers that could assist in early diagnosis…
2020 American Transplant Congress
Early Pancreas Allograft Failure is Associated with Donor Hypertension
C. Masset¹, J. Branchereau¹, L. Badet², C. Kerleau¹, C. Legendre³, D. Glotz⁴, G. Karam¹, D. Cantarovich¹
¹University Hospital of Nantes, Nantes, France, ²University Hospital of Lyon, Lyon, France, ³Necker Hospital, Paris, France, ⁴Saint Louis Hospital, Paris, France
*Purpose: About 10% of pancreas allografts are lost prematurely due to thrombosis. Despite identification of numerous risk factors, the incidence of early failure did not…
2020 American Transplant Congress
Steroid Dependence at 1 Yr in Kidney Transplant Recipients Initiated on Early Steroid Withdrawal Protocol: Associated Risk Factors and Prognosis
M. Yaqub, D. Mishler, T. Taber, A. Sharfuddin, W. Goggins, O. Adebiyi
Indiana University, Indianapolis, IN
*Purpose: Early steroid withdrawal (ESW) has become a stable immunosuppression regimen in the USA with a third of patients now discharged steroid-free immediately post-transplant. However,…