Articles tagged "Graft failure"

2020 American Transplant Congress
Immune-Mediated Injury and Eplet Mismatches – Profiling Population-Level Interactions
H. Mohammadhassanzadeh¹, W. Zhang², W. Klement³, H. Gebel⁴, P. Keown⁵, K. Oualkacha⁶, R. Sapir-Pichhadze¹
¹Medicine, McGill University, Montreal, QC, Canada, ²McGill University, Montreal, QC, Canada, ³Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, ⁴Emory University Hospital, Atlanta, GA, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Université du Québec À Montréal, Montreal, QC, Canada
*Purpose: HLA genes are in linkage disequilibrium with each other. Sequence defined HLA targets (eplets) are associated with alleles and may be shared within and…
2020 American Transplant Congress
Factors Influencing Background Cell-Free DNA Levels: Implications for Donor-Derived Cell-Free DNA Assessment in Transplant Patients
P. Gauthier, A. Aleshin, S. Shchegrova, T. Mckenna, E. Kalashnikova, S. Sharma, H. Sethi, R. Salari, R. Swenerton, Z. Demko, B. Zimmermann, P. Billings
Natera, Inc., San Carlos, CA
*Purpose: Detecting elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the plasma of transplant recipients has been used as a metric to determine graft injury…
2020 American Transplant Congress
Uromodulin to Osteopontin Ratio in Deceased Donor Urine is Associated with Kidney Graft Outcomes
S. G. Mansour¹, C. Liu², Y. Jia², P. Reese³, I. Hall⁴, T. El-Achkar⁵, K. LaFavers⁵, W. Obeid², M. Thangamani⁶, A. Rosenberg², M. Doshi⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, S. Mohan¹¹, B. Schröppel¹², P. Daneshpajouhnejad², P. Singh¹³, F. Weng¹⁴, H. Thiessen-Philbrook², C. Parikh²
¹Yale, New Haven, CT, ²Johns Hopkins, Baltimore, MD, ³UPenn, Philadelphia, PA, ⁴Univ of Utah, Salt Lake City, UT, ⁵Indiana Univ, Bloomington, IN, ⁶Cornell, New York, NY, ⁷Univ of Michigan, Ann Arbor, MI, ⁸Montefiore, Bronx, NY, ⁹Univ of Maryland, College Park, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Columbia, NY, NY, ¹²Univ Hosp, Ulm, Germany, ¹³Thomas Jefferson, Philadelphia, PA, ¹⁴St. Barnabas, Livingston, NJ
*Purpose: Deceased-donor kidneys often experience extensive injury, activating adaptive and maladaptive pathways. While these adaptive and maladaptive mechanisms are initiated in donor kidneys prior to…
2020 American Transplant Congress
Peak DSA Levels Pre-Transplant but Not at Transplant Predict Graft Survival
A. Y. Choi¹, D. Olaso¹, T. Risoli Jr², M. Kuchibhatla², Z. Fitch³, R. Schmitz³, P. M. Schroder³, A. Jackson³, M. Manook³, J. Yoon³, A. B. Farris⁴, J. Kwun³, S. J. Knechtle³
¹Duke University School of Medicine, Durham, NC, ²Duke Biostatistics, Epidemiology, and Research Design Core, Duke University, Durham, NC, ³Department of Surgery, Duke University Medical Center, Durham, NC, ⁴Department of Pathology, Emory University Hospital, Atlanta, GA
*Purpose: Immunization to major histocompatibility complex (MHC) antigens is a barrier in kidney transplantation (KTx) due to higher risk of antibody-mediated rejection (AMR) and graft…
2020 American Transplant Congress
Life Supporting Orthotopic Cardiac Xenotransplantation from Genetically Engineered Donor Pigs
A. K. Singh¹, C. E. Goerlich¹, T. Zhang¹, I. Tatarov¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, B. Lewis¹, A. Hershfeld¹, F. Sentz¹, D. Ayares², D. Kaczorowski¹, B. Griffith¹, M. M. Mohiuddin¹
¹Department of Surgery, University of Maryland Baltimore, Baltimore, MD, ²Revivicor Inc, Blacksburg, VA
*Purpose: Cardiac xenotransplantation (CXTx) might be an alternative treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically-engineered (GE) pig heart is…
2020 American Transplant Congress
A Simple Scoring System for Risk Stratification in Liver Transplantation after Donor Liver Biopsy
J. A. Steggerda, M. B. Bloom, K. Mahendraraj, T. Ramos, T. Todo, T. V. Brennan, N. N. Nissen, A. S. Klein, I. K. Kim
Surgery, Cedars-Sinai Medical Center, Los Angeles, Los Angeles, CA
*Purpose: Macrosteatosis (MaS) identified on donor liver biopsy (DLBx) influences organ utilization but alone is not predictive of outcomes following liver transplantation (LT). Here we…
2020 American Transplant Congress
Evaluation of Bronchial Artery Revascularization in Lung Transplantation: A Systematic Review and Meta-Analysis
T. J. O'Malley¹, A. M. Jordan¹, E. J. Maynes¹, A. Saxena¹, K. W. Prochno¹, T. K. Rajab², H. T. Massey¹, R. C. Daly³, V. Tchantchaleishvili¹
¹Division of Cardiac Surgery, Thomas Jefferson University, Philadelphia, PA, ²University of Colorado, Aurora, CO, ³Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN
*Purpose: Bronchial artery revascularization (BAR) during lung transplantation has been hypothesized to improve early tracheal healing and delay the onset of bronchiolitis obliterans. We evaluated…
2020 American Transplant Congress
CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction
P. Shrestha, L. Batra, M. T. Malik, M. Tan, E. S. Yolcu, H. Shirwan
Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY
*Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…
2020 American Transplant Congress
Clinical Outcomes from a Mobile Health, Pharmacist-Led Intervention: 12-Month Results of the Transafe Rx Randomized Controlled Trial
D. Taber, J. Hirsch, Z. Su, J. McGillicuddy, A. Posadas, J. Fleming
Med Univ of South Carolina, Charleston, SC
*Purpose: Medication errors and non-adherence are predominant causes of poor graft outcomes in kidney transplant (KTX) recipients. The primary aim of the TRANSAFE Rx RCT…
2020 American Transplant Congress
Impact of Eplet Mismatches on the Risk of Graft Loss: Not All Eplets are Created Equal
H. Mohammadhassanzadeh¹, W. Klement², H. Gebel³, B. Foster⁴, P. Keown⁵, K. Oualkacha⁶, R. Sapir-Pichhadze¹
¹Medicine, McGill University, Montreal, QC, Canada, ²Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, ³Emory University Hospital, Atlanta, GA, ⁴Montreal Children's Hospital, Montreal, QC, Canada, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Université du Québec À Montréal, Montreal, QC, Canada
*Purpose: To mitigate risks related to HLA incompatibility, we assessed whether some unique sequence defined HLA targets (eplets) are associated with graft failure while others…