Articles tagged "Graft failure"

2021 American Transplant Congress
Outcomes of Simultaneous Pancreas-Kidney Transplants from Donation After Circulatory Death Donors in the UK: A National Registry Analysis
N. Karydis¹, M. Ibrahim², C. Counter², J. Casey³, P. Friend⁴, C. Watson⁵, C. Callaghan¹
¹Nephrology and Transplantation, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, ²NHS Blood and Transplant, Bristol, United Kingdom, ³Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, ⁴Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ⁵Department of Surgery, Addenbrooke's Hospital and Cambridge NIHR Biomedical Research Campus, Cambridge, United Kingdom
*Purpose: The UK is a world leader in the use of pancreases from donation after circulatory death (DCD) donors. However, there is a perception that…
2021 American Transplant Congress
Endothelial-to-Myofibroblast Transition (en-mt) and Low Expression of Capillary Vegf Enhance the Development of Interstitial Fibrosis and Glomerulosclerosis Induced by Microvascular Destruction in Antibody-Mediated Rejection (abmr) Patients
B. Ozdemir¹, E. Akcay¹, A. Ok Atilgan¹, M. Haberal²
¹Department of Pathology, Baskent University, Ankara, Turkey, ²Division of Transplantation, Department of General Surgery, Baskent University, Ankara, Turkey
*Purpose: Interstitial fibrosis (IF) and glomerulosclerosis (GS) are the most important cause of graft loss. Although the rate of microvascular destruction (MVD) is similar in…
2021 American Transplant Congress
The Impact of Living Donors Aged 70 and Older on Living Donor Kidney Transplantation
T. Hiramitsu, T. Tomosugi, K. Futamura, M. Okada, N. Goto, T. Ichimori, S. Narumi, Y. Watarai
Nagoya Daini Red Cross Hospital, Nagoya Aichi, Japan
*Purpose: Due to the discrepancy between the number of patients on the waiting list and oragn supply, living donor kidney transplantation is more required. The…
2021 American Transplant Congress
Hla Antigens and Recurrence of Focal Segmental Glomerulosclerosis in Pediatric Kidney Transplantation
B. I. Shaw¹, A. Ochoa², C. Chan², R. A. Gbadegesin³, A. M. Jackson¹, E. T. Chambers³
¹Surgery, Duke University, Durham, NC, ²Biostatistics and Bioinformatics, Duke University, Durham, NC, ³Pediatrics, Duke University, Durham, NC
*Purpose: Recurrence of focal segmental glomerulosclerosis (FSGS) reduces graft survival yet risk factors remain elusive. While HLA risk alleles are known to be associated with…
2021 American Transplant Congress
Evolving Trends in Risk Profiles and Outcomes in Older Adults Undergoing Kidney Re-Transplantation
S. Sandal¹, J. Ahn², M. Cantarovich¹, N. Chu², D. Segev², M. McAdams DeMarco²
¹McGill University, Montreal, QC, Canada, ²Johns Hopkins University, Baltimore, MD
*Purpose: The half-life of a kidney transplant (KT) is 8-12 years, and a significant proportion of patients end up with graft loss at age ≥65…
2021 American Transplant Congress
Is There a Role for Pre-Operative Angiographic Kidney Embolization Prior to Allograft Nephrectomy?
M. Jacobs¹, R. Stratta¹, D. Harriman², A. Farney¹, J. Rogers¹, G. Orlando¹, A. Reeves-Daniel¹, C. Jay¹
¹Wake Forest Baptist Health, Winston Salem, NC, ²University of British Columbia, Vancouver, BC, Canada
*Purpose: To determine if morbidity associated with allograft nephrectomy (AN) of a failed or diseased kidney transplant (KT) is improved by pre-operative angiographic kidney embolization…
2021 American Transplant Congress
Do Pretransplant C-peptide Levels Influence Outcomes in Simultaneous Pancreas-Kidney Transplantation? A Matched Case-Control Study
K. B. Gurung, V. Gurram, J. Rogers, A. C. Farney, G. Orlando, C. L. Jay, A. Reeves-Daniel, A. Mena-Gutierrez, N. Sakhovskaya, W. Doares, S. Kaczmorski, M. D. Gautreaux, R. J. Stratta
Abdominal Transplant Surgery, Wake Forest Baptist Medical Center, Winston-Salem, NC
*Purpose: Experience with simultaneous pancreas-kidney transplant (SPKT) in uremic patients (pts) with detectable pretransplant C-peptide (Cp) levels and a “type 2” diabetes mellitus (DM) phenotype…
2021 American Transplant Congress
The Predictive Factors of Survival in Re-listed Patients Who Received Initial Liver Transplants Using Donation After Circulatory Death Grafts
Y. Fouda, A. Moro, J. Mcvey, D. Firl, M. Fujiki, D. Teresa, F. Aucejo, C. Quintini, C. H. Kwon, K. Hashimoto, B. Eghtesad, K. Narayanan Menon, C. Miller, K. Sasaki
Cleveland Clinic, Cleveland, OH
*Purpose: The inherent risk of livers from donors after circulatory death (DCD) is well known such as primary non-function (PNF) and increased rates of biliary…
2021 American Transplant Congress
Clazakizumab for the Treatment of Chronic Active Antibody-Mediated Rejection in Kidney Transplant Recipients: Phase 3 IMAGINE Study Design
P. Nickerson¹, G. Böhmig², S. Chadban³, D. Kumar⁴, R. B. Mannon⁵, T. van Gelder⁶, S. Adler⁷, E. Chong⁷, A. Djamali⁸
¹University of Manitoba, Winnipeg, MB, Canada, ²Medical University of Vienna, Vienna, Austria, ³University of Sydney, Sydney, Australia, ⁴University of Toronto, Toronto, ON, Canada, ⁵University of Nebraska Medical Center, Omaha, NE, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷CSL Behring, King of Prussia, PA, ⁸University of Wisconsin, Madison, WI
*Purpose: Chronic active antibody-mediated rejection (CAMR) is a major cause of allograft loss with no approved drugs for its treatment. Currently, off-label regimens recommended by…
2021 American Transplant Congress
Impact of Donor Kidney Biopsy on Kidney Yield and Post-Transplant Outcomes
C. Wang¹, J. Wetmore¹, A. Wey², N. Salkowski², J. Snyder², A. Israni¹
¹Nephrology, Hennepin County Medical Center, Minneapolis, MN, ²Scientific Registry of Transplant Recipients, Minneapolis, MN
*Purpose: Kidney procurement biopsy findings, such as Glomerulosclerosis (GS) is frequently used to determine kidney quality, but it remains unclear the degree of GS in…